Anti-proliferative activity and target cell catabolism of the vitamin D analog 1α,24(S)-(OH)2D2 in normal and immortalized human epidermal cells

Biochemical Pharmacology

Volumn 52, Issue 1, 1996, Pages 133-140

  Jones, Glenville ^a   Byford, Valarie ^a   Makin, Hugh L J ^b   Kremer, Richard ^c   Rice, Robert H ^d   DeGraffenried, Lea Ann ^d   Knutson, Joyce C ^e   Bishop, Charles W ^e  

^a QUEEN S UNIVERSITY   (Canada)

^b QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^c MCGILL UNIVERSITY   (Canada)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e Lunar Corporation   (United States)

Author keywords

1 ,24(S) dihydroxyvitamin D2; 1 ,25 dihydroxyvitamin D3; anti proliferative activity; GC MS; HPK1A ras; human epidermal cells; human keratinocyte; NMR; vitamin D analogs

Indexed keywords

1,24,25 TRIHYDROXYCOLECALCIFEROL; 1,25 DIHYDROXYERGOCALCIFEROL; CALCIPOTRIOL; CALCITRIOL; DRUG METABOLITE; TACALCITOL; VITAMIN D DERIVATIVE;

ANIMAL CELL; ARTICLE; CATABOLISM; CELL LINE; CELL METABOLISM; CELL PROLIFERATION; CONTROLLED STUDY; DRUG ACTIVITY; DRUG METABOLISM; EPIDERMIS CELL; GAS CHROMATOGRAPHY; GENE EXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; KERATINOCYTE; MASS SPECTROMETRY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; PSORIASIS; TARGET CELL;

EID: 0030008637     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/0006-2952(96)00173-6     Document Type: Article

References (32)

1. Jones G and Calverley MJ, A dialogue on analogues. Newer vitamin D drugs for use in bone disease, psoriasis and cancer. Trends Endocrinol Metab 4: 297-303, 1993.
2. Kragballe K, Vitamin D analogs in the treatment of psoriasis. J Cell Biochem 49: 46-52, 1992.
3. Calverley MJ, Synthesis of MC903, a biologically active vitamin D metabolite analogue. Tetrahedron 43: 4609-4619, 1987.
4. Kragballe K, Gjertsen BT, de Hoop D, Karlsmark T, van de Kerkhof PCM, Larkö O, Nieboer C, Roed-Petersen J, Strand A and Tikjøb G, Double-blind, right/left comparison of calcipotriol and betamethasone valerate in treatment of psoriasis vulgaris. Lancet 337: 193-196, 1991.
5. Bikle DD, Clinical counterpoint: Vitamin D: New actions, new analogs, new therapeutic potential. Endocr Rev 13: 765-785, 1992.
6. 2 in mammals. Biochemistry 29: 578-582, 1990.
7. 2 made in the human hepatoma, Hep3B. Biochem J 310: 233-241, 1995.
8. 3 to calcitroic acid. Biochem J 262: 173-180, 1989.
9. 3 in target cells. J Nutr Sci Vitaminol (Tokyo) (Special Issue) 75-78, 1992.
10. Masuda S, Strugnell S, Calverley M, Makin HLJ, Kremer R and Jones G, In vitro metabolism of the anti-psoriatic vitamin D analog, calcipotriol, in two cultured human keratinocyte models. J Biol Chem 269: 4794-4803, 1994.
11. 2 chain during catabolism by a keratinocyte cell line. In: Vitamin D. A Pluripotent Steroid Hormone: Structural Studies, Molecular Endocrinology and Clinical Applications (Eds. Norman AW, Bouillon R and Thomasset M), pp. 190-191. Walter de Gruyter, Berlin, 1994.
12. Henderson J, Sebag M, Rhim J, Goltzman D and Kremer R, Dysregulation of parathyroid hormone-like peptide expression and secretion in a keratinocyte model of tumor progression. Cancer Res 51: 6521-6528, 1991.
13. 3 in a keratinocyte model of tumor progression. J Biol Chem 267: 12162-12167, 1992.
14. Hsieh J-C, Jurutka PW, Galligan MA, Terpening CM, Haussler CA, Samuels DS, Shimizu Y, Shimizu N and Haussler MR, Human vitamin D receptor is selectively phosphorylated by protein kinase C on serine 51, a residue crucial to its trans-activation function. Proc Natl Acad Sci USA 88: 9315-9319, 1991.
15. 3 mediated transcriptional activation. Mol Endocrinol 5: 373-385, 1991.
16. Allen-Hoffman BL and Rheinwald JG, Polycyclic aromatic hydrocarbon mutagenesis of human epidermal keratinocytes in culture. Proc Natl Acad Sci USA 81: 7802-7806, 1984.
17. Rice RH, Steinmann KE, deGraffenried LA, Qin Q, Taylor N and Schlegel R, Elevation of cell cycle control proteins during spontaneous immortalization of human keratinocytes. Mol Biol Cell 4: 185-194, 1993.
18. Dilworth FJ, Calverley MJ, Makin HLJ and Jones G, Increased biological activity of 20-epi-1,25-dihydroxyvitamin D3 is due to reduced catabolism and altered protein binding. Biochem Pharmacol 47: 987-993, 1994.
19. Qaw F, Calverley MJ, Schroeder NJ, Trafford DJH, Makin HLJ and Jones G, In vivo metabolism of the vitamin D analog, dihydrotachysterol. J Biol Chem 268: 282-292, 1993.
20. Sambrook J, Fritsch EF and Maniatis T, Molecular Cloning: A Laboratory Manual, 2nd Edn, pp. 16.42-16.44. Cold Spring Harbor Laboratories, Cold Spring Harbor, NY, 1989.
21. Napoli JL, Koszewski NJ and Horst RL, Isolation and identification of vitamin D metabolites. Methods Enzymol 123: 127-140, 1986.
22. 2. Biochemistry 27: 5785-5790, 1988.
23. 3-26,23-lactone. J Biol Chem 259: 884-889, 1984.
24. Guo Y, Strugnell S, Back D and Jones G, Transfected human liver cytochrome P450 hydroxylates vitamin D analogs at different side-chain positions. Proc Natl Acad Sci USA 90: 8668-8672, 1993.
25. 3 production by human keratinocytes. J Clin Invest 78: 557-566, 1986.
26. Bikle DD, Gee E and Pillai S, Regulation of keratinocyte growth, differentiation, and vitamin D metabolism by analogs of 1,25-dihydroxyvitamin D. J Invest Dermatol 101: 713-718, 1993.
27. 3 in cultured human keratinocytes. J Cell Biochem 59: 117-122, 1995.
28. Bouillon R, Allevvart K, Xiang DZ, Tan BK and Van Baelen H, Vitamin D analogs with low affinity for the vitamin D binding protein: Enhanced in vitro and decreased in vivo activity. J Bone Miner Res 6: 1051-1057, 1991.
29. Kissmeyer A-M, Mathiasen IS, Latini S and Binderup L, Pharmacokinetic studies of vitamin D analogues: Relationship to vitamin D binding protein (DBP). Endocrine 3: 263-266, 1995.
30. Stern P, A monolog on analogs. Calcif Tissue Int 33: 1-4, 1981.
31. 3 following oral administration. J Bone Mineral Res 8: S224, 1993.
32. Sorenson H, Binderup L, Calverley MJ, Hoffmeyer L and Anderson NR, In vitro metabolism of calcipotriol (MC903), a vitamin D analogue. Biochem Pharmacol 40: 333-341, 1990.