Inhibition of acetylcholinesterase by physostigmine analogs: Conformational mobility of cysteine loop due to the steric effect of the alkyl chain

Journal of Biochemical and Molecular Toxicology

Volumn 16, Issue 2, 2002, Pages 64-69

  Gavuzzo, Enrico ^a   Pomponi, Massimo ^b  

^a CNR   (Italy)

^b CATHOLIC UNIVERSITY   (Italy)

Author keywords

Cysteine loop (Cys67 Cys94); Inhibition of AChE; Steric effects

Indexed keywords

ACETYLCHOLINESTERASE; ALKYL GROUP; AROMATIC COMPOUND; CHOLINESTERASE INHIBITOR; CYSTEINE; DONEPEZIL; PHYSOSTIGMINE; PHYSOSTIGMINE DERIVATIVE; PHYSOVENINE; TACRINE; TRYPTOPHAN;

ARTICLE; CHEMICAL INTERACTION; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; DRUG STRUCTURE; ELECTROPHORETIC MOBILITY; ENZYME ACTIVITY; ENZYME CONFORMATION; ENZYME INHIBITION; ENZYME INHIBITOR COMPLEX; ENZYME KINETICS; HYPOTHESIS; STEREOCHEMISTRY;

ACETYLCHOLINESTERASE; ANIMALS; CHOLINESTERASE INHIBITORS; ELECTROPHORUS; MODELS, MOLECULAR; PHYSOSTIGMINE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0036251240     PISSN: 10956670     EISSN: None     Source Type: Journal    
DOI: 10.1002/jbt.10026     Document Type: Article

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