Differential tramadol and O-desmethyl metabolite levels in brain vs. plasma of mice and rats administered tramadol hydrochloride orally

Journal of Clinical Pharmacy and Therapeutics

Volumn 27, Issue 2, 2002, Pages 99-106

  Tao, Q ^a   Stone Jr , D J ^b   Borenstein, M R ^a   Codd, E E ^b   Coogan, T P ^b   Desai Krieger, D ^b   Liao, S ^b   Raffa, R B ^a,c  

^a TEMPLE UNIVERSITY   (United States)

^b R W JOHNSON PHARMACEUTICAL RES I   (United States)

^c TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Active metabolite; Brain; Gas chromatography; Plasma; Tramadol

Indexed keywords

DRUG METABOLITE; TRAMADOL;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG DISTRIBUTION; DRUG UPTAKE; GAS CHROMATOGRAPHY; MALE; MOUSE; NONHUMAN; RAT;

ADMINISTRATION, ORAL; ANALGESICS, OPIOID; ANIMALS; BRAIN CHEMISTRY; DOSE-RESPONSE RELATIONSHIP, DRUG; MALE; MICE; RATS; TRAMADOL;

EID: 0036248152     PISSN: 02694727     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2710.2002.00384.x     Document Type: Article

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