A novel cell line derived from de novo acute myeloblastic leukaemia with trilineage myelodysplasia which proliferates in response to a Notch ligand, Delta-1 protein

British Journal of Haematology

Volumn 117, Issue 2, 2002, Pages 373-378

  Tohda, Shuji ^a   Sakano, Seiji ^b   Ohsawa, Mai ^a   Murakami, Naomi ^a   Nara, Nobuo ^a  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^b ASAHI KASEI CORPORATION   (Japan)

Author keywords

AML TLD; Cell line; Delta; Jagged; Notch

Indexed keywords

CD33 ANTIGEN; CD34 ANTIGEN; CD7 ANTIGEN; ERYTHROPOIETIN; GRANULOCYTE COLONY STIMULATING FACTOR; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; GROWTH FACTOR; INTERLEUKIN 3; INTERLEUKIN 6; JAGGED1; LIGAND; MESSENGER RNA; MICROSOMAL AMINOPEPTIDASE; NOTCH RECEPTOR; NOTCH1 RECEPTOR; NOTCH2 RECEPTOR; PROTEIN; PROTEIN DELTA 1; THROMBOPOIETIN; UNCLASSIFIED DRUG;

ACUTE MYELOBLASTIC LEUKEMIA; ADULT; ANTIGEN EXPRESSION; ARTICLE; BLAST CELL; CASE REPORT; CELL DIFFERENTIATION; CELL GROWTH; CELL PROLIFERATION; CELL STRUCTURE; CHEMOTHERAPY; CLINICAL FEATURE; CONTROLLED STUDY; DISEASE COURSE; DOSE RESPONSE; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; IMMUNOPHENOTYPING; KARYOTYPE; LEUKEMIA CELL; MALE; MYELODYSPLASIA; PRIORITY JOURNAL; PROTEIN EXPRESSION;

CALCIUM-BINDING PROTEINS; CELL DIVISION; GRANULOCYTE COLONY-STIMULATING FACTOR; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; INTERLEUKIN-3; KARYOTYPING; LEUKEMIA, MYELOCYTIC, ACUTE; MALE; MEMBRANE PROTEINS; MIDDLE AGED; MYELODYSPLASTIC SYNDROMES; PROTEINS; RECEPTOR, NOTCH1; RECEPTOR, NOTCH2; RECEPTORS, CELL SURFACE; TRANSCRIPTION FACTORS; TUMOR CELLS, CULTURED;

EID: 0036248065     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.2002.03446.x     Document Type: Article

References (17)

1. Clinical and laboratory features of de novo acute myeloblastic leukemia with trilineage myelodysplasia
2. Notch-1-induced delay of human hematopoietic progenitor cell differentiation is associated with altered cell cycle kinetics
3. TAN-1, the human homolog of the Drosophila Notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms
4. World Health Organization classification of neoplastic diseases of the hematopoietic and lymphoid tissues: Report of the clinical advisory committee meeting - Airlie house, Virginia, November 1997
5. Stromal expression of Jagged-1 promotes colony formation by fetal hematopoietic progenitor cells
6. The notch ligand Jagged-1 represents a novel growth factor of human hematopoietic stem cells
7. Human homologues of Delta-1 and Delta-4 function as mitogenic regulators of primitive human hematopoietic cells
8. Poor response to intensive chemotherapy in de novo acute myeloid leukemia with trilineage myelodysplasia
9. Morphological comparison of dysplastic changes between de novo acute myeloid leukemia with trilineage myelodysplasia and AML developed from de novo myelodysplastic syndrome
10. The human homolog of rat Jagged1 expressed by marrow stroma inhibits differentiation of 32D cells through interaction with Notch1
11. Notch as a mediator of cell fate determination in hematopoiesis: Evidence and speculation
12. Autocrine growth mechanisms of the progenitors of blast cells in acute myeloblastic leukemia
13. Modulation of growth factor receptors on acute myeloblastic leukemia cells by retinoic acid
14. Establishment of a double Philadelphia chromosome-positive acute lymphoblastic leukemia-derived cell line. TMD5: Effects of cytokines and differentiation inducers on the growth of the cells
15. Expression of Notch1 and Jagged1 proteins in acute myeloid leukemia cells
16. The Notch ligand, Jagged-1, influences the development of primitive hematopoietic precursor cells
17. An antisense oligonucleotide to the Notch ligand Jagged enhances fibroblast growth factor-induced angiogenesis in vitro