Granulocyte/monocyte apheresis induces sustained increases in CD4 T cells in HIV-1 infected patients with poor CD4 T cell restoration after suppression of viral replication by HAART

Journal of Biological Regulators and Homeostatic Agents

Volumn 16, Issue 1, 2002, Pages 58-63

  Hasson, H ^a   Saniabadi, A ^a   Alfano, M ^a   Trabattoni, D ^a   Ferrante, P ^a   Lillo, F ^a   Clerici, M ^a   Lazzarin, A ^a   Beretta, Alberto ^a  

^a SAN RAFFAELE HOSPITAL   (Italy)

Author keywords

HAART; HIV 1; Immune reconstitution; Monocytes

Indexed keywords

ANTIRETROVIRUS AGENT; CD4 ANTIGEN; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 2; PROTEINASE INHIBITOR; RNA DIRECTED DNA POLYMERASE INHIBITOR; TUMOR NECROSIS FACTOR ALPHA; VIRUS DNA;

ADULT; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG EFFICACY; DRUG RESPONSE; FEMALE; GRANULOCYTE; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INFECTION RISK; LEUKAPHERESIS; LYMPHOCYTE COUNT; MALE; MONOCYTE; OPPORTUNISTIC INFECTION; PATIENT CODING; PHASE 2 CLINICAL TRIAL; RANDOMIZED CONTROLLED TRIAL; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; TREATMENT INDICATION; VIRUS INHIBITION; VIRUS LOAD;

ALPHAVIRUS; DNA VIRUSES; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 0036245552     PISSN: 0393974X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (16)

1. Discrepant responses to triple combination antiretroviral therapy in advanced HIV disease
2. Determinants of paradoxical CD4 cell reconstitution after protease inhibitor-containing antiretroviral regimen
3. Clinical outcome of patients with HIV-1 infection according to immunologic and virologic response after 6 months of highly active antiretroviral therapy
4. Efficacy of low-dose subcutaneous interleukin-2 to treat advanced human immunodeficiency type 1 in persons with < 250/ml CD4 T cells and undetectable plasma virus load
5. Comparison of subcutaneous and intravenous interleukin-2 in asymptomatic HIV-1 infection: A randomised controlled trial
6. Efficacy of low-dose intermittent subcutaneous (IL)-2 in antiviral drug-experienced human immunodeficiency virus-infected persons with detectable virus load: A controlled study of 3 IL-2 regimens with antiviral drug therapy
7. Use of cytokines in human immunodeficiency virus-infected patients: Colony-stimulating factors, erythropoietin and interleukin-2
8. Increased expression of CD23 Fc (epsilon) receptor II by peripheral monocytes of AIDS patients
9. Elevated levels of circulating cachectin/tumor necrosis factor in patients with acquired immunodeficiency syndrome
10. Tumor necrosis factor α activates human immunodeficiency virus type 1 through induction of nuclear factor binding to the NF-kB site long terminal repeat
11. Detection of infectious HIV in circulating monocytes from patients on prolonged highly active antiretroviral therapy
12. Monocytes harbour replication-competent, non-latent HIV-1 in patients on highly active antiretroviral therapy
13. Evidence for Human Immunodeficiency type 1 replication in vivo in CD14+ monocytes and its potential role as a source of virus in patients on highly active antiretroviral therapy
14. Ex vivo purging of circulating monocytes results in immunovirologic improvement in partially HAART responder HIV-infected patients
15. Immuno-virological improvement in partially HAART responder HIV-infected patients by monocyte adsorption apheresis
16. Viral load and burden modification following early antiretroviral therapy of primary HIV-I infection