Chronic cannabis use in the Compassionate Investigational New Drug program: An examination of benefits and adverse effects of legal clinical Cannabis

Journal of Cannabis Therapeutics

Volumn 2, Issue 1, 2002, Pages 3-57

  Russo, Ethan ^a,c   Mathre, Mary Lynn ^a   Byrne, Al ^a   Velin, Robert ^a,b   Bach, Paul J ^a   Sanchez Ramos, Juan ^a   Kirlin, Kristin A ^a  

^a University of South Florida ^*

^b UNIVERSITY OF SOUTH FLORIDA   (United States)

^c UNIVERSITY OF MONTANA   (United States)

Author keywords

Analgesia; Cannabis; Chronic pain; Compassionate use; Drug policy; Epidemiology; FDA; Glaucoma; Hashish; Herbal medicine; History of medicine; Investigational new drug; Medical marijuana; Multiple sclerosis; NIDA; Spasticity

Indexed keywords

ACETYLSALICYLIC ACID; ALPRAZOLAM; AMFEBUTAMONE; ANALGESIC AGENT; BACLOFEN; BENZODIAZEPINE; BUSPIRONE; CANNABIS; DIAZEPAM; DRONABINOL; FLUOXETINE; HYDROMORPHONE; HYPNOTIC AGENT; ISONIAZID; LORAZEPAM; METHAQUALONE; METHYLPHENIDATE; MIRTAZAPINE; MUSCLE RELAXANT AGENT; NARCOTIC ANALGESIC AGENT; OMEPRAZOLE; PETHIDINE; PYRIDOXINE; RIFAMPICIN; ROFECOXIB; SERTRALINE; THIORIDAZINE; TIMOLOL MALEATE; TRAZODONE; UNINDEXED DRUG; VENLAFAXINE;

ADULT; ANAMNESIS; ARTICLE; CANNABIS ADDICTION; CASE REPORT; CHRONIC PAIN; COHORT ANALYSIS; CONTROLLED STUDY; DEPRESSION; DISORIENTATION; DOSE RESPONSE; DRUG EFFICACY; DRUG QUALITY; DRUG RESEARCH; DRUG SAFETY; DRUG STERILITY; DRUG USE; ELECTROENCEPHALOGRAPHY; EPIGASTRIC PAIN; EVENT RELATED POTENTIAL; FATIGUE; FEMALE; FOOD AND DRUG ADMINISTRATION; GLAUCOMA; HEALTH STATUS; HORMONE DETERMINATION; HUMAN; IMMUNOASSAY; KIDNEY FAILURE; KIDNEY TUBERCULOSIS; LEGAL ASPECT; LUNG FUNCTION; LUNG FUNCTION TEST; MALE; MULTIPLE SCLEROSIS; MUSCLE SPASM; MUSCULOSKELETAL DISEASE; NAUSEA; NEUROLOGIC EXAMINATION; NEUROPSYCHOLOGICAL TEST; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; RISK BENEFIT ANALYSIS; SEDATION; SPASTICITY; STANDARDIZATION; THORAX PAIN; THORAX RADIOGRAPHY;

EID: 0036245359     PISSN: 15299775     EISSN: None     Source Type: Journal    
DOI: 10.1300/J175v02n01_02     Document Type: Article

References (71)

1. Short-term effects of cannabinoids in human immunodeficiency virus (HIV) infection: Clinical safety results
2. The P300 brain potential is reduced in smokers
3. Effects of chronic marijuana use on testosterone, luteinizing hormone, follicle stimulating hormone, prolactin and cortisol in men and women
4. Effects of frequent marijuana use on brain tissue volume and composition
5. Medical studies in long-term hashish users: I. Physical and neurological examinations
6. Immune system
7. Drugs and immmunity: Cannabinoids and their role in decreased resistance to infectious disease
8. Marijuana and cannabinoids: Effects on infections, immunity and AIDS
9. Cerebral atrophy in young cannabis smokers
10. The effect of motivational instructions on P300 amplitude
11. Cannabis in Costa Rica: A study of chronic marihuana use
12. Gynecomastia and cannabis smoking. A non-association among US Army soldiers
13. Preference for high-versus low-potency marijuana
14. Some physical characteristics of NIDA marijuana cigarettes
15. Absence of cerebral atrophy in chronic cannabis users. Evaluation by computerized transaxial tomography
16. The 94-day cannabis study
17. The lack of association of marijuana and other recreational drugs with progression to AIDS in the San Francisco Men's Health Study
18. Cognitive correlates of long-term cannabis use in Costa Rican men
19. Bronchial pathology in chronic marijuana smokers: A light and electron microscopic study
20. Why marijuana smoke harm reduction?
21. Waterpipe study
22. Cannabis "vaporization": A promising strategy for smoke harm reduction
23. Harm reduction associated with inhalation and oral administration of cannabis and THC
24. Practical hints
25. Neurological and neuroradiological examination of chronic cannabis smokers
26. Gynecomastia in marihuana users
27. Marihuana smoking and intraocular pressure
28. Tetrahydrocannabinol content and differences in marijuana smoking behavior
29. Diurnal variation in the P300 component of human cognitive event-related potential
30. Marijuana and immunity
31. Report of the Indian Hemp Drugs Commission, 1893-94
32. Hashish smoking and T-lymphocytes
33. Marijuana. Report of the Indian Hemp Drugs Commission, 1893-1894
34. No evidence for a role of alcohol or other psychoactive drugs in accelerating immunodeficiency in HIV-1-positive individuals. A report from the Multicenter AIDS Cohort Study
35. Are choice and self-administration of marijuana related to delta 9-THC content?
36. Marijuana, immunity and infection
37. Psychological test characteristics of long-term hashish users
38. Depression of plasma testosterone levels after chronic intensive marihuana use
39. Computed tomographic examination of heavy marijuana smokers
40. Cannabis use and cognitive decline in persons under 65 years of age
41. P300 amplitude as a possible correlate of frontal degeneration in schizophrenia
42. Acute effects of marihuana on luteinizing hormone in menopausal women
43. Effects of chronic marihuana use on integrated plasma testosterone and lutenizing hormone levels
44. Marihuana smoking suppresses luteinizing hormone in women
45. Hormonal system and reproduction
46. Inhibition of cellular mediated immunity in marihuana smokers
47. The marihuana problem in the city of New York; Sociological, medical, psychological and pharmacological studies
48. II. Clinical electroencephalography and echoencephalography in long-term hashish users
49. Glaucoma and cannabinoids
50. Anandamide structure-activity relationships and mechanisms of action on intraocular pressure in the normotensive rabbit model
51. Auditory and visual P300 event related potentials are not altered in medically and psychiatrically normal chronic marihuana users
52. Health care use by frequent marijuana smokers who do not smoke tobacco
53. Marijuana & AIDS: Pot, politics & PWA's in America
54. Muscle spasm, pain & marijuana therapy: Testimony from federal and state court proceedings on marijuana's medical use in the treatment of multiple sclerosis, paralysis, and chronic pain
55. Marijuana Rx: The patients' fight for medicinal pot
56. Marijuana and brain dysfunction: Selected research issues
57. Ganja in Jamaica: A medical anthropological study of chronic marihuana use
58. Role of cannabis and cannabinoids in pain management
59. Respiratory effects of non-tobacco cigarettes: A longitudinal study in general population
60. Marijuana use and mortality
61. Long term effects of cannabis on psyche and cognition
62. Cannabis and cognitive functioning, International research monographs in the addictions
63. Evoked potential primer: Visual, auditory, and somatosensory evoked potentials in clinical diagnosis
64. Hashish: Studies of long-term use
65. 1 with age
66. Effects of smoked marijuana on the lung and its immune defenses: Implications for medicinal use in HIV-infected patients
67. Respiratory risks from marijuana smoking
68. The impact of ethanol and Marinol/marijuana usage on HIV+/AIDS patients undergoing azidothymidine, azidothymidine/dideoxycytidine, or dideoxyinosine therapy
69. Prospects for new cannabis-based prescription medicines
70. Marijuana use and increased risk of squamous cell carcinoma of the head and neck
71. Marijuana myths, marijuana facts: A review of the scientific evidence