Properties of group I allergens from grass pollen and their relation to cathepsin B, a member of the C1 family of cysteine proteinases

European Journal of Biochemistry

Volumn 269, Issue 8, 2002, Pages 2083-2092

  Grobe, Kay ^a   Pöppelmann, Marco ^b   Becker, Wolf Meinhard ^b   Petersen, Arnd ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b RESEARCH CENTER BORSTEL   (Germany)

Author keywords

Cathepsin B; Cell wall; Expansin; Group I allergen; Proteinase

Indexed keywords

ALLERGEN; AMINO ACID; CATHEPSIN B; CYSTEINE PROTEINASE; HISTIDINE; PAPAIN; PATULIN;

ARTICLE; BIOCHEMISTRY; CATALYSIS; CELL GROWTH; CELL WALL; CONTROLLED STUDY; GIARDIA LAMBLIA; GLYCOSYLATION; GRASS; GRASS POLLEN; NONHUMAN; NUCLEOTIDE SEQUENCE; PH; PHLEUM PRATENSE; PICHIA PASTORIS; PLANT CELL; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN STABILITY; SITE DIRECTED MUTAGENESIS;

ALLERGENS; AMINO ACID SEQUENCE; CATALYTIC DOMAIN; CATHEPSIN B; ENZYME ACTIVATION; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PICHIA; PLANT PROTEINS; POACEAE; POLLEN; SEQUENCE ALIGNMENT; SEQUENCE ANALYSIS, PROTEIN;

ANIMALIA; ARCHEZOA; GIARDIA; GIARDIA INTESTINALIS; PHLEUM PRATENSE; PICHIA; PICHIA PASTORIS;

EID: 0036241733     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1432-1033.2002.02856.x     Document Type: Article

References (46)

1. Epitope analysis of isoforms of the major allergen Phl p V by fingerprinting and microsequencing
2. Studies on the carbohydrate moieties of the timothy grass pollen allergen Phl p I
3. Characterization of grass group I allergens in timothy grass pollen
4. Group I allergens of grass pollen as cell wall-loosening agents
5. An expansin gene expressed in ripening strawberry fruit
6. Modification of expansin protein abundance in tomato fruit alters softening and cell wall polymer metabolism during ripening
7. Differential expression of expansin gene family members during growth and ripening of tomato fruit
8. Expression of a divergent expansin gene is fruit-specific and ripening- regulated
9. Creeping walls, softening fruit, and penetrating pollen tubes: The growing roles of expansins
10. Localized upregulation of a new expansin gene predicts the site of leaf formation in the tomato meristem
11. From the cover: Local expression of expansin induces the entire process of leaf development and modifies leaf shape
12. Cell wall loosening by expansins
13. Expansin mode of action on cell walls. Analysis of wall hydrolysis, stress relaxation, and binding
14. Disruption of hydrogen bonding between plant cell wall polymers by proteins that induce wall extension
15. New genes and new biological roles for expansins
16. Enzymes and other agents that enhance cell wall extensibility
17. Loosening of plant cell walls by expansins
18. Grass group I allergens (beta-expansins) are novel, papain-related proteinases
19. Characterization of long-term extension of isolated cell walls from growing cucumber hypocotyls
20. Grass group I pollen allergens (beta-expansins) lack proteinase activity and do not cause wall loosening via proteolysis
21. Zymographic techniques for detection and characterization of microbial proteases
22. A primitive enzyme for a primitive cell: The protease required for excystation of Giardia
23. Delineating functionally important regions and residues in the cathepsin B propeptide for inhibitory activity
24. Inhibition of cathepsin B by its propeptide: Use of overlapping peptides to identify a critical segment
25. Families of cysteine peptidases
26. Gene structure of mouse cathepsin B
27. Removal of an inter-domain hydrogen bond through site-directed mutagenesis: Role of serine 176 in the mechanism of papain
28. Characterization of cathepsin B specificity by site-directed mutagenesis. Importance of Glu245 in the S2-P2 specificity for arginine and its role in transition state stabilization
29. Alignment/phylogeny of the papain superfamily of cysteine proteases
30. Structural and functional roles of asparagine 175 in the cysteine protease papain
31. Carbohydrate and amino acid analyses of Giardia muris cysts
32. Cell-wall lytic enzymes (autolysins) of Chlamydomonas reinhardtii are (hydroxy) proline-specific proteases
33. Secretion of functional papain precursor from insect cells. Requirement for N-glycosylation of the pro-region
34. Activation of procathepsin B in human hepatoma cells. The conversion into the mature enzyme relies on the action of cathepsin B itself
35. Correct processing of the kiwifruit protease actinidin in transgenic tobacco requires the presence of the C-terminal pro-peptide
36. Expression and processing of a hormonally regulated beta-expansin from soybean
37. Expansin action on cells with tip growth and diffuse growth
38. Autolysis and extension of isolated walls from growing cucumber hypocotyls
39. Molecular cloning and sequence analysis of expansins: A highly conserved, multigene family of proteins that mediate cell wall extension in plants
40. Human cathepsin B is a metastable enzyme stabilized by specific ionic interactions associated with the active site
41. Expansins and cell wall expansion
42. Regulated secretion of a serine protease that activates an extracellular matrix-degrading metalloprotease during fertilization in Chlamydomonas
43. Activation of the cell wall degrading protease, lysin, during sexual signalling in Chlamydomonas: The enzyme is stored as an inactive, higher relative molecular mass precursor in the periplasm
44. Cell wall regeneration in Chlamydomonas: Accumulation of mRNAs encoding cell wall hydroxyproline-rich glycoproteins
45. Noncovalent complexes between the lysosomal proteinase cathepsin B and its propeptide account for stable, extracellular, high molecular mass forms of the enzyme