Experimental validation of deuterium oxide-mediated antitumoral activity as it relates to apoptosis in murine malignant astrocytoma cells

Journal of Neurosurgery

Volumn 96, Issue 5, 2002, Pages 900-908

  Uemura, Takeshi ^a   Moritake, Kouzo ^a   Akiyama, Yasuhiko ^a   Kimura, Yoriyoshi ^a   Shingu, Takashi ^a   Yamasaki, Toshiki ^a  

^a SHIMANE UNIVERSITY   (Japan)

Author keywords

Apoptosis; Caspase; Cytotoxicity; Deuterium oxide; Glioma

Indexed keywords

BENZYLOXYCARBONYLVALYLALANYLASPARTYL FLUOROMETHYL KETONE; CASPASE; DEUTERIUM OXIDE; FLUORESCEIN ISOTHIOCYANATE; LIPOCORTIN 5; PROPIDIUM IODIDE; TETRAZOLIUM; TRYPAN BLUE;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; ASTROCYTOMA; ASTROCYTOMA CELL; CELL CYCLE; CELL CYCLE G2 PHASE; CELL LINE; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG CYTOTOXICITY; DRUG EFFECT; DRUG EFFICACY; ENZYME ACTIVATION; ENZYME ACTIVITY; FLOW CYTOMETRY; METAPHASE; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; ROUS SARCOMA ONCOVIRUS; VALIDATION PROCESS;

EID: 0036238003     PISSN: 00223085     EISSN: None     Source Type: Journal    
DOI: 10.3171/jns.2002.96.5.0900     Document Type: Article

References (31)

1. Heavy water delays growth of human carcinoma in nude mice
2. Deuterium oxide enhancement of Chinese hamster cell response to gamma radiation
3. Caspase-3-like activity determines the type of cell death following ionizing radiation in MOLT-4 human leukaemia cells
4. Effect of deuterium oxide on the reproductive potential of mice
5. Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages
6. Bax-induced caspase activation and apoptosis via cytochrome c release from mitochondria is inhibitable by Bcl-xL
7. Wachstum von Gewebezellen in schwerem Wasser
8. The effects of deuterium oxide (2H2O) on the polymerization of tubuline in vitro
9. Fas activation of p38 mitogen-activated protein kinase signalling pathway requires ICE/CED-3 family proteases
10. Chemical and biological studies with deuterium
11. Course of deuteriation and some physiological effects of deuterium in mice
12. A comparison of the cytoplasmic domains of the fas receptor and the p75 neurotrophin receptor
13. Mitosis arrested by deuterium oxide. Light microscopic, immunofluorescence and ultrastructual characterization
14. Effects of deuterium oxide on growth of Hela, L and L-5178Y cells
15. Ingibirovanie D2O interfaznoi gibeli timotsitov
16. Deuterium oxide protects against hyperthermic cell death: Evidence for role of interfacial water
17. Increased death receptore 5 expression by chemotherapeutic agents in human gliomas causes synergistic cytotoxity with tumor necrosis factor-related apoptosis-inducing ligand in vitro and in vivo
18. Actinomycin D and staurosporine, potent apoptosis inducers in vitro, are potentially effective chemotherapeutic agents against glioblastoma multiforme
19. Interactions of intercalating fluorochromes with DNA analyzed by conventional and fluorescence lifetime flow cytometry utilizing deuterium oxide
20. Deuterium oxide (heavy water) arrests the cell cycle of PtK2 cells during interphase
21. Transbilayer movement of phospholipids in red cell and platelet membranes
22. Growth of Hela cells in heavy water
23. Heat protection by deuterium oxide of heat sensitive and wild-type Chinese hamster ovary cells
24. Studies on the metabolic error in Refsum's disease
25. 2O) on cancer cells
26. 1OB-boric acid
27. 2+ homeostasis in spontaneously hypertensive rats
28. A novel assay for apoptosis. Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labeled Annexin V
29. The antidepressants imipramine, clomipramine, and citalopram ind uce apoptosis in human acute myeloid leukemia HL-60 cells via caspase-3 activation
30. Oxygen-glucose deprivation induces inducible nitric oxide synthase and nitrotyrosine expression in cerebral endothelial cells
31. Characteristic immunological responses to an experimental mouse brain tumor