Mechanisms of cytotoxic effects of heavy water (deuterium oxide: D2O) on cancer cells

Anti-Cancer Drugs

Volumn 9, Issue 8, 1998, Pages 715-725

  Takeda, Hiroshi ^a   Nio, Yoshinori ^a   Omori, Hiroshi ^a   Uegaki, Ken ^a   Hirahara, Noriyuki ^a   Sasaki, Susumu ^a   Tamura, Katsuhiro ^a   Ohtani, Hiroki ^a  

^a SHIMANE UNIVERSITY   (Japan)

Author keywords

Anticancer agent; Chemotherapy; Deuterium oxide; Heavy water

Indexed keywords

ANTINEOPLASTIC AGENT; DEUTERIUM OXIDE; DNA FRAGMENT; HYDROGEN; MATRIGEL; NUCLEIC ACID; PROTON; TRYPAN BLUE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER CELL; CANCER CELL CULTURE; CANCER GROWTH; CANCER SURVIVAL; CELL VACUOLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOSTASIS; CYTOTOXICITY; DIGESTIVE SYSTEM CANCER; DNA SYNTHESIS INHIBITION; FIBROBLAST CULTURE; GROWTH INHIBITION; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; MOUSE; NEUTRON; NONHUMAN; NUDE MOUSE; PRIORITY JOURNAL; PROTEIN SYNTHESIS INHIBITION; TUMOR XENOGRAFT;

3T3 CELLS; ANIMALS; ANTINEOPLASTIC AGENTS; DEUTERIUM OXIDE; DIGESTIVE SYSTEM NEOPLASMS; DNA, NEOPLASM; HUMANS; IN SITU NICK-END LABELING; MICE; MICE, INBRED BALB C; NEOPLASM INVASIVENESS; NEOPLASM PROTEINS; NEOPLASMS, EXPERIMENTAL; RNA; TRANSPLANTATION, HETEROLOGOUS; TUMOR CELLS, CULTURED;

EID: 0031730395     PISSN: 09594973     EISSN: None     Source Type: Journal    
DOI: 10.1097/00001813-199809000-00007     Document Type: Article

References (27)

1. Somlyai G, Jancso G, Jakli G, et al. Naturally occurring deuterium is essential for the normal growth rate of cells. FEBS Lett 1993; 317: 1-4.
2. 2+ homeostasis in spontaneously hypertensive rat. J Hypertension 1990; 8: 185-9.
3. Laeng RH, Mini RL, Laissue JA, Schindler R. Radio protection of cultured cells by preincubation in medium containing deuterium oxide. Int J Radiat Biol 1991; 59: 165-73.
4. Michael F, Altermatt HJ, Gebbers JO, Bally E, Berchtold W, Laissue JA. Radioprotection by pretreatment with deuterated water: cytokinetic changes in the small intestine of the mouse. Virchow Archive B Cell Pathol 1988; 54: 214-20.
5. Fischer A. Wachstum von Gewebezellen in schwerem Wasser. Protoplasma 1936; 26: 51-5.
6. Manson LA, Defendi V, Hartzell RW, Jr, Kritchevsky D. Effect of deuterium oxide on growth of Hela, L and L-5178Y cells. Proc Soc Exp Biol Med 1960; 105: 481-3.
7. Siegel BV, Lund RO, Wellings SR, Bostic WL. Growth of Hela cells in heavy water. Exp Cell Res 1959; 19: 187-9.
8. Altermatt HJ, Gebbers JO, Laissue JA. Heavy water delays growth of human carcinoma in nude mice. Cancer 1988; 62: 462-6.
9. Lamprecht J, Schroeter D, Paweletz N. Mitosis arrested by deuterium oxide. Light microscopic, immunofluorescence and ultrastructural characterization. Eur J Cell Biol 1990; 51: 303-12.
10. Ovejera AA, Houchens DP, Baker AD. Chemotherapy of human xenografts in genetically athymic mice. Ann Clin Lab Sci 1978; 8: 50-6.
11. Gavrieli Y, Sherman Y, Ben-Sasson SA. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J Cell Biol 1992; 119: 493-501.
12. Cole SP. Rapid chemosensitivity testing of human lung tumor cells using the MTT assay. Cancer Chemother Pharmacol 1986; 17: 259-63.
13. Nio Y, Imai S, Shiraishi T, et al. Chemosensitivity correlation between the primary tumors and simultaneous metastatic lymph nodes of patients evaluated by DNA synthesis inhibition assay. Cancer 1990; 65: 1273-8.
14. Nio Y, Tamura K, Tsubono M, et al. Antitumor chemosensitivity changes between the original and recurrent tumors after successful chemotherapy selected according to the sensitivity assay. Ann Surg 1995; 221: 89-99.
15. Terranova VP, Hujanen KS, Loeb DM, Martin GR, Thornburg L, Glushko V. Use of reconstituted basement membrane to measure cell invasiveness and select for highly invasive tumor cells. Proc Natl Acad Sci USA 1986; 83: 465-9.
16. Albini A, Iwamoto Y, Kleinman HK, et al. A rapid in vitro assay for quantitating the invasive potential of tumor cells. Cancer Res 1987; 47: 3239-45.
17. Schroeter O, Lamprecht J, Eckhardt R, Futterman G, Paweletz N. Deuterium oxide (heavy water) arrests the cell cycle of PtK2 cells during interphase. Eur J Cell Biol 1992; 58: 363-70.
18. Pinard J, Bellemare G, Aubin A, Daigneault R, Cousineau GH. Uptake and incorporation of leucine and thymidine in developing sea urchin eggs. Exp Cell Res 1969; 56: 254-8.
19. 2O in developing sea urchin eggs. Cell Struct Funct 1989; 14: 95-111.
20. Lamprecht J, Schroeter D, Paweletz N. Dearrangement of microtubule array in interphase and mitotic PtK2 cells treated with deuterium oxide (heavy water). J Cell Sci 1991; 98: 463-73.
21. 2O)-induced shape changes, movements and F-actin-redistribution in human neutrophil granulocytes. Eur J Cell Biol 1988; 47: 320-6.
22. 2O) on the polymerization of tubulin in vitro. Biochem Biophys Acta 1984; 800: 21-7.
23. Katz JJ, Crespi HL, Czajka DM, Finkel AJ. Course of deuteriation and some physiological effects of deuterium in mice. Am J Physiol 1962; 203: 907-13.
24. Altermatt HJ, Gebbers JO, Laissue JA. Heavy water enhances the antineoplastic effect of 5-fluoro-uracil and bleomycin in nude mice bearing human carcinoma. Int J Cancer 1990; 45: 475-80.
25. Steinberg D, Mize CE, Avigan J, et al. Studies on the metabolic error in Refsum's disease. J Clin Invest 1967; 46: 313-22.
26. Katz JJ. Chemical and biological studies with deuterium. Am Sci 1960; 48: 544-80.
27. Czajka DM, Finkel AJ. Effect of deuterium oxide on the reproductive potential of mice. Ann NY Acad Sci 1960; 84: 770-9.