Reciprocal age-related changes in GAP-43/B-50, substance P and calcitonin gene-related peptide (CGRP) expression in rat primary sensory neurones and their terminals in the dorsal horn of the spinal cord and subintima of the knee synovium

Neuroscience Research

Volumn 42, Issue 4, 2002, Pages 251-260

  Hukkanen, Mika ^a,b   Platts, Louise A M ^c   Corbett, Steven A ^c   Santavirta, Seppo ^d   Polak, Julia M ^c   Konttinen, Yrjö T ^a,b,d  

^a UNIVERSITY OF HELSINKI   (Finland)

^b ORTON ORTHOPAEDIC HOSPITAL   (Finland)

^c IMPERIAL COLLEGE SCHOOL OF MEDICINE   (United Kingdom)

^d HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

Author keywords

Calcitonin gene related peptide; Dorsal root ganglion; Growth associated protein GAP 43 B 50; Neurovascular control; Nociception; Substance P

Indexed keywords

CALCITONIN GENE RELATED PEPTIDE; NEUROMODULIN; SUBSTANCE P;

AGING; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; IMMUNOCYTOCHEMISTRY; IMMUNOREACTIVITY; KNEE; MALE; MICROVASCULATURE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SATELLITE CELL; SENSORY NERVE; SPINAL CORD DORSAL HORN; SYNOVIUM;

AGING; ANIMALS; CALCITONIN GENE-RELATED PEPTIDE; CELL COUNT; DOWN-REGULATION; GANGLIA, SPINAL; GAP-43 PROTEIN; IMMUNOHISTOCHEMISTRY; KNEE JOINT; MALE; NEUROTRANSMITTER AGENTS; POSTERIOR HORN CELLS; PRESYNAPTIC TERMINALS; RATS; RATS, SPRAGUE-DAWLEY; SUBSTANCE P; SYNOVIAL MEMBRANE; UP-REGULATION;

EID: 0036236583     PISSN: 01680102     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-0102(02)00003-2     Document Type: Article

References (40)

1. Increased levels of substance P and calcitonin gene-related peptide in rat adjuvant arthritis. A combined immunohistochemical and radioimmunoassay analysis
2. Neuropeptides and neurotrophin receptor mRNAs in primary sensory neurons of aged rats
3. Neuropeptides, nitric oxide synthase and GAP-43 in B4-binding and RT97 immunoreactive primary sensory neurons: normal distribution pattern and changes after peripheral nerve transection and aging
4. Inflammatory oedema induced by synergism between calcitonin gene-related peptide (CGRP) and mediators of increased vascular permeability
5. Aberrant vascularity and von Willebrand factor distribution in inflamed synovial membrane
6. GAP-43 is expressed by nonmyelin forming Schwann cells of the peripheral nervous system
7. The distribution of GAP-43 in normal rat spinal cord
8. Perivascular noradrenergic and peptide-containing nerves show different patterns of changes during development and ageing in the guinea pig
9. Neuron atrophy during aging: programmed or sporadic?
10. Calcitonin gene-related peptide immunoreactivity in the spinal cord of man and of eight other species
11. Decreased neuropeptide content in the spinal cord of aged rats: the effect of GM1 ganglioside
12. Endocrine and vagal controls of sympathetically dependent neurogenic inflammation
13. Rapid proliferation of calcitonin gene-related peptide-immunoreactive nerves during healing of rat tibial fracture suggests neural involvement in bone growth and remodelling
14. Effect of increasing age on the endothelium-mediated relaxation of rat blood vessels in vitro
15. Ultrastructure of the synovial sensory peptidergic fibers is distinctively altered in different phases of adjuvant induced arthritis in rats: ultramorphological characterization combined with morphometric and immunohistochemical study for substance P, calcitonin gene related peptide, and protein gene product 9.5
16. Age-related decrease of calcitonin gene-related peptide-containing vasodilator innervation in the mesenteric resistance vessel of spontaneously hypertensive rat
17. Peripheral and spinal neural mechanisms in arthritis, with particular reference to treatment of inflammation and pain
18. Intraneuronal substance P contributes to the severity of experimental arthritis
19. Distribution of GAP-43 in relation to CGRP and synaptic vesicle markers in rat skeletal muscles during development
20. GAP-43-like immunoreactivity in normal adult rat sciatic nerve, spinal cord, and motoneuron: axonal transport and effect of spinal cord transection
21. GAP-43 and its relation to autonomic and sensory neurons in sciatic nerve and gastrocnemius muscle in rat
22. Effect of age on vascular content of calcitonin gene-related peptide and mesenteric vasodilator nerve activity in the rat
23. Monoarthritis in the rat knee induces bilateral and time-dependent changes in substance P and calcitonin gene-related peptide immunoreactivity in the spinal cord
24. (8-37)
25. Expression of NGF receptor and GAP-43 mRNA in DRG neurons during collateral sprouting and regeneration of dorsal cutaneous nerves
26. Ultrastructural study of calcitonin gene-related peptide-, neurokinins- and somatostatin-immunoreactive neurones in rat dorsal root ganglia. Evidence of the colocalisation of different peptides in single secretory granules
27. Effect of cutting or crushing the rat sciatic nerve on synthesis of substance P by isolated L5 dorsal root ganglia
28. Reciprocal regulation of tachykinin- and vasoactive intestinal peptide gene expression in rat sensory neurons following cut and crush injury
29. Prepro-VIP and preprotachykinin mRNAs in the rat dorsal root ganglion cells following peripheral axotomy
30. CGRP and β-CGRP mRNAs are differentially regulated in the rat spinal cord and dorsal root ganglion
31. Affinity-purified anti-B-50 protein antibody: interference with the function of the phosphoprotein B-50 in synaptic plasma membranes
32. B-50, the growth associated protein-43: modulation of cell morphology and communication in the nervous system
33. Injury-associated induction of GAP-43 expression displays axon branch specificity in rat dorsal root ganglion neurons
34. A comparative study by morphometry of the microvasculature in normal and rheumatoid synovium
35. Axonal transport and localization of B-50/GAP-43-like immunoreactivity in regenerating sciatic and facial nerves of the rat
36. Upregulation of GAP-43/B-50 in Schwann cells of denervated motor endplates and in motoneurones after rat facial nerve crush
37. Origin of sympathetic and sensory innervation of the knee joint. A retrograde axonal tracing study in the rat
38. The growth-associated protein GAP-43 appears in dorsal root ganglion cells and in the dorsal horn of the rat spinal cord following peripheral nerve injury
39. Denervation of the motor endplate results in the rapid expression by terminal Schwann cells of the growth-associated protein GAP-43