Artificial skin: Past, present and future

International Journal of Artificial Organs

Volumn 25, Issue 3, 2002, Pages 163-173

  Beele, Hilde ^a  

^a GHENT UNIVERSITY HOSPITAL   (Belgium)

Author keywords

Artificial skin; Skin; Wound healing

Indexed keywords

ARTIFICIAL SKIN; RECENT RESEARCHES; SKIN SUBSTITUTES; WOUND DRESSINGS; WOUND HEALING;

ARTIFICIAL ORGANS;

ACIDIC FIBROBLAST GROWTH FACTOR; BASIC FIBROBLAST GROWTH FACTOR; BIOBRANE; BIOMATERIAL; COLONY STIMULATING FACTOR 1; EPIDERMAL GROWTH FACTOR; GROWTH FACTOR; INTERLEUKIN 1; KERATINOCYTE GROWTH FACTOR; PLATELET DERIVED GROWTH FACTOR; SOMATOMEDIN C; TRANSFORMING GROWTH FACTOR ALPHA; TRANSFORMING GROWTH FACTOR BETA1; TRANSFORMING GROWTH FACTOR BETA2; TRANSFORMING GROWTH FACTOR BETA3; TUMOR NECROSIS FACTOR ALPHA; VASCULOTROPIN;

ALLOGRAFT; ARTIFICIAL SKIN; AUTOTRANSPLANTATION; BIOMEDICAL TECHNOLOGY ASSESSMENT; BURN; CLINICAL PRACTICE; CLINICAL TRIAL; DIABETIC FOOT; HEALTH CARE COST; HUMAN; MEDICAL RESEARCH; NONHUMAN; PATHOPHYSIOLOGY; PROSTHESIS MATERIAL; REVIEW; SKIN CULTURE; SKIN FUNCTION; SKIN INJURY; TREATMENT INDICATION; WOUND; WOUND DRESSING; WOUND HEALING; XENOGRAFT;

EID: 0036232308     PISSN: 03913988     EISSN: None     Source Type: Journal    
DOI: 10.1177/039139880202500302     Document Type: Review

References (70)

1. Culturing skin in vitro for wound therapy
2. Artificial skin
3. Cutaneous wound healing
4. Role of platelet-derived growth factor in vivo
5. Wounding alters epidermal connexin expression and gap junction - Mediated intercellular communication
6. Fibronectin matrix deposition and fibronectin receptor expression in healing and normal skin
7. Transforming growth factor beta-1 decreases interstitial collagenase in healing human fetal skin
8. The activity of collagenase-I is required for keratinocyte migration on a type I collagen matrix
9. Epidermal growth factor and transforming growth factor-α
10. The function of KGF in morphogenesis of epithelium and reepithelialization of wounds
11. Transforming growth factor β
12. Fibronectin provides a conduit for fibroblast transmigration from collagenous stroma into fibrin clot provisional matrix
13. Apoptosis mediates the decrease in cellularity during the transition between granulation tissue and scar
14. Mechanisms of angiogenesis
15. Blood vessel formation: What is its molecular basis?
16. Vascular endothelial growth factor mediates angiogenic activity during the proliferative phase of wound healing
17. Angiogenesis and angiogenesis inhibition: An overview
18. The role of the myofibroblast in wound healing and fibrocontractive diseases
19. Hypertrophic scars, keloids, and contractures: The cellular and molecular basis for therapy
20. Matrix metalloproteinases (MMMPs) and their physiological inhibitors (TIMPs) are differentially expressed during excisional skin wound repair
21. Distinct populations of stromal cells express collagenase-3 (MMP-13) and collagenase-1 (MMMP-1) in chronic ulcers but not in normally healing wounds
22. Differences in cellular infiltrate and extracellular matrix of chronic diabetic and venous ulcers versus acute wounds
23. Methods of skin coverage: Achieving temporary and permanent coverage
24. Artificial skin for wound healing
25. Serial cultivation of strains of human epidermal keratinocytes: The formation of colonies from single cells
26. Skin replacements: The biotechnological quest for optimal wound closure
27. Greffe epidermique
28. Kultur erwachsener Haut auf festem Nährboden
29. The cultivation of adult mammalian skin epithelium in vitro
30. Transplantation studies on sheets of pure epidermal epithelium and on epidermal cell suspensions
31. In vitro culture of human epithelial cells
32. Cultivation, frozen storage, and clonal growth of normal human epidermal keratinocytes in serum-free medium
33. Fresh versus cryopreserved cultured allografts for the treatment of chronic skin ulcers
34. Grafting of burns with cultured epithelium prepared from autologous epidermal cells
35. Grafting of burn patients with allografts of cultured epidermal cells
36. Grafting of skin ulcers with cultured autologous epidermal cells
37. Treatment of chronic venous ulcers with sheets of cultured allogenic keratinocytes
38. Treatment of chronic erosions of junctional epidermolysis bullosa with human epidermal allografts
39. Design of an artificial skin. I. Basic design principles
40. Development and use of a living skin equivalent
41. The culture of skin. A review of theories and experimental methods
42. Cultured cells for the treatment of disease
43. Wound coverage with cultured autologous keratinocytes: Use after burn wound excision including biopsy follow up
44. Addendum: Multicenter experience with cultured epidermal autograft for treatment of burns
45. Acceleration of skin regeneration from cultured epithelial autografts by transplantation to homograft dermis
46. Grafting of cultured allogeneic epidermis on second and third degree burn wounds in 26 patients
47. Allogeneic cultured keratinocytes vs cadaveric skin to cover wide mesh autogenous split-thickness skin grafts
48. Repeated cultured epidermal allografts in the treatment of chronic leg ulcers of various origins
49. Treatment of chronic wounds with cultured skin substitutes: A pilot study
50. Ulcers in pretibial epidermolysis bullosa: Grafting with autologous meshed split-thickness skin and allogeneic cultured keratinocytes
51. Treatment of dystrophic epidermolysis bullosa with autologous meshed split-thickness skin grafts and allogeneic cultured keratinocytes
52. Cultured keratinocyte allografts and wound healing in severe recessive dystrophic epidermolysis bullosa
53. Long-term survival and immunological tolerance of human epidermal allografts produced in culture
54. Rejection, after a slightly prolonged survival time, of Langerhans cell-free allogeneic cultured epidermis used for wound coverage in humans
55. Survival of cultured allografts in patients with burns assessed with probe specific for Y chromosome
56. Use of cultured epidermal autografts and dermal allografts as skin replacement after burn injury
57. Uses and abuses of a biosynthetic dressing for partial skin thickness burns
58. The clinical experience of bioengineered skin products
59. Clinical trials of a biosynthetic temporary skin replacement, Dermagraft Transitional Covering, compared with cryopreserved human cadaver skin for temporary coverage of excised burn wounds
60. Artificial skin in massive burns: Results to ten years
61. Clinical trials of a living derma tissue replacement beneath meshed, split-thickness skin grafts on excised burn wounds
62. The use of cultured dermis in the treatment of diabetic foot ulcers
63. New skin for old. Developments in biological skin substitutes
64. Bioengineered skin: Manufacturing, safety and quality control
65. The use of bioengineered skin for burn patients
66. Rapid healing of venous ulcers and lack of clinical rejection with an allogeneic cultured human skin equivalent
67. The Apligraf Burn Study Group. The effect of a tissue-engineered bilayered living skin analog, over meshed split-thickness autografts on the healing of excised burn wounds