A partially humanized monoclonal antibody to human IFN-γ inhibits cytokine effects both in vitro and in vivo

Scandinavian Journal of Immunology

Volumn 55, Issue 3, 2002, Pages 284-292

  Fiorentini, S ^a   De Panfilis, G ^a   Pasolini, G ^a   Bonfanti, C ^a   Caruso, A ^a  

^a UNIVERSITY OF BRESCIA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; GAMMA INTERFERON ANTIBODY; HLA DR ANTIGEN; IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN LIGHT CHAIN; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY IGMB17; UNCLASSIFIED DRUG;

ADULT; ANTIBODY AFFINITY; ANTIBODY ENGINEERING; ANTIGEN BINDING; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; HUMAN TISSUE; HYPERSENSITIVITY REACTION; IMMUNOGENICITY; IMMUNOREACTIVITY; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR BINDING;

ANIMALS; ANTIBODIES, MONOCLONAL; BASE SEQUENCE; CELL LINE; CLONING, MOLECULAR; CYTOKINES; DNA, RECOMBINANT; HUMANS; IMMUNOTHERAPY; INTERFERON TYPE II; MICE; MOLECULAR SEQUENCE DATA; NEUTRALIZATION TESTS; PROTEIN ENGINEERING; RECOMBINANT FUSION PROTEINS; TUBERCULIN;

EID: 0036230439     PISSN: 03009475     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-3083.2002.01039.x     Document Type: Article

References (48)

1. The IFN-γ receptor: A paradigm for cytokine receptor signaling
2. The cell biology of macrophage activation
3. Effect of recombinant IL2 and γ-IFN on proliferation and differentiation of human B cells
4. Interferon-γ and B cell stimulatory factor-1 reciprocally regulate Ig isotype production
5. Regulation of IFN-γ induction in human peripheral blood cells by exogenous and enogenously produced interleukin 2
6. Immune IFN. A pleiotrophic lymphokine with multiple effects
7. Natural human antibodies to γ-interferon interfere with the immunomodulating activity of the lymphokine
8. Interferon and inflammation
9. Disseminated tuberculosis in interferon-gamma gene-disrupted mice
10. An essential role for interferon-gamma in resistance to Mycobacterium tuberculosis infection
11. Tumor necrosis factor and interferon gamma relevance for immune regulation and genetic predisposition to autoimmune disease
12. In vivo treatment of (NZBxNZW) F1 lupus-like nephritis with monoclonal antibody to γ-interferon
13. Experimental therapy of systemic lupus erythematosus: The treatment of NZB/W mice with mouse soluble interferon-gamma receptor inhibits the onset of glomerulonephritis
14. Monoclonal antibody against interferon gamma can prevent experimental cerebral malaria and its associated overproduction of tumor necrosis factor
15. Primary demyelination in transgenic mice expressing interferon-γ
16. Myasthenia gravis-like syndrome induced by expression of interferon gamma in the neuromuscolar junction
17. + lymphocytes of patients with AIDS syntesize increased amounts of interferon-γ
18. V-region and class specific RT-PCR amplification of human immunoglobulin heavy and light chain genes from B-cell lines
19. Humanization of an antibody recognizing a breast cancer specific epitope by CDR-grafting
20. The influence of fetal calf serum on interferon-γ induced HLA-DR expression on U937 cells
21. 2-terminal region of Hhuman interferon-γ inhibits its antiproliferative activity without affecting its internalization
22. The possibility of distinguishing a subset of antigen-presenting cells from macrophages by means of anti-S-100 protein sera
23. Quantitative studies on nonlymphoid mononuclear cell subpopulation in cutaneous infiltrates
24. Kinetic expression of endothelial adhesion molecules and relationship to leukocyte recruitment in two cutaneous models of inflammation
25. Generation of a large combinatorial library of the immunoglobulin repertoire in phage lambda
26. Prevention of spontaneous autoimmune diabetes in diabete-prone BB rats by prophylactic treatment with antirat interferon-gamma antibody
27. Construction, purification and characterization of new interferon γ (IFNγ) inhibitor proteins
28. IFN-gamma receptor-Ig fusion proteins. Half-life, immunogenicity and in vivo activity
29. Essential pathogenetic role for interferon (IFN-) gamma in concanavalin A-induced T cell-dependent hepatitis: Exacerbation by exogenous IFN-gamma and prevention by IFN-gamma receptor-immunoglobulin fusion protein
30. Interferon γ receptor extracellular domain expressed as IgG fusion protein in Chinese Hamster Ovary cells. Purification, biochemical characterization and stoichiometry of binding
31. The integrity of the ball-and socket joint between V and C domains is essential for complete activity of a humanized antibody
32. +) in classical delayed-type (tuberculin) hypersensitivity reaction in human skin
33. A binary plasmid system for shuffing combinatorial antibody libraries
34. Evidence for distinct contribution of heavy and light chains to restriction of antibody recognition of the HIV-1 principal neutralization determinant
35. A short term study of chimeric monoclonal antibody cA2 to tumor necrosis factor alpha for Crohn's disease [Crohn's Disease cA2 Study Group]
36. Interleukin-2-receptor blockade with daclizumab to prevent acute rejection in renal transplantation [Daclizumab Triple Therapy Study Group]
37. Treatment of rheumatoid arthritis with chimeric monoclonal antibodies to tumor necrosis factor
38. Infliximab (chimeric anti-tumour-necrosis factor alpha monoclonal antibody) versus placebo in rheumatoid arthritis patients receiving concomitant methotrexate: A randomised phase III trial [ATTRACT study group]
39. Serological analysis of human anti-human antibody response colon cancer patients treated with repeated doses of humanized monoclonal antibody A33
40. 4
41. Potential therapeutic use of antibodies directed towards HuIFN-gamma
42. Interferon-gamma: Biology and role in pathogenesis
43. Cytokines in neuroinflammatory disease: Role of myelin autoreactive T-cell production of interferon-gamma
44. Interferon-gamma secretion by peripheral blood T-cell subset in multiple sclerosis: Correlation with disease phase and interferon-beta therapy
45. Treatments of multiple sclerosis with gamma interferon: Exacerbations associated with activation of the immune system
46. HbsAg retention sensitizes the hepatocyte to injury by physiological concentrations of interferon-γ
47. Coronary atherosclerosis in transplanted mouse hearts
48. Interferon-γ elicits arteriosclerosis in the absence of leukocytes