Contribution of lysosomes to the subcellular distribution of basic drugs in the rat liver

Pharmaceutical Research

Volumn 13, Issue 6, 1996, Pages 902-906

  Ishizaki, Junko ^a   Yokogawa, Koichi ^a   Hirano, Masako ^a   Nakashima, Emi ^a   Sai, Yoshimichi ^a   Ohkuma, Shoji ^a   Ohshima, Tohru ^a   Ichimura, Fujio ^a  

^a KANAZAWA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BIPERIDEN; CHLORPROMAZINE; IMIPRAMINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELLULAR DISTRIBUTION; DRUG BINDING SITE; DRUG DISTRIBUTION; DRUG TISSUE LEVEL; DRUG UPTAKE; INTRAPERITONEAL DRUG ADMINISTRATION; LIVER PARENCHYMA; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; ANTIDEPRESSIVE AGENTS, TRICYCLIC; ANTIPARKINSON AGENTS; ANTIPSYCHOTIC AGENTS; BIPERIDEN; CHEMISTRY, PHYSICAL; CHLORPROMAZINE; DEXTRANS; FLUORESCEIN-5-ISOTHIOCYANATE; IMIPRAMINE; IONOPHORES; LIVER; LYSOSOMES; MALE; ORGANELLES; RATS; RATS, WISTAR; SUBCELLULAR FRACTIONS;

EID: 0029896233     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1016061330387     Document Type: Article

References (15)

1. K. Yokogawa, E. Nakashima, and F. Ichimura. Effect of fat tissue volume on the distribution kinetics of hiperiden as a function of age in rats. Drug Metab. Dispos. 18:258-263 (1990).
2. K. Yokogawa, E. Nakashima, J. Ishizaki, H. Maeda, T. Nagano, and F. Ichimura. Relationships in the structure-tissue distribution of basic drugs in the rabbit, Pharm. Res. 7:691-706 (1990).
3. A. Nishiura, T. Murakami, Y. Higashi, and N. Yata. Role of phosphatidylserine in the cellular and subcellular lung distribution of quinidine in rats. Pharm. Res. 5:209-213 (1988).
4. H. Yoshida, K. Okumura, and R. Hori. Contribution of monoamine oxidase(MAO) to the binding of tertiary basic drugs in isolated perfused rat lung. Pharm. Res. 7:398-401 (1990).
5. B. Poole and S. Ohkuma. Effect of weak bases on the intralysosomal pH in mouse peritoneal macrophages. J. Cell Biol. 90:665-669 (1981).
6. P. Stoffel, T. Burkart, U. E. Honegger, and U. N. Wiesmann. Subcellular distribution of the antidepressant drug desipramine in cultured human fibroblasts alter chronic administration. Drug-effect on the subcellular distribution of accumulated phospholipids. Biochem. Pharmacol. 36:655-662 (1987).
7. G. Cramb. Selective lysosomal uptake and accumulation of the beta-adrenergic antagonist propranolol in cultured and isolated cell systems. Biochem. Pharmacol. 35:1365-372 (1986).
8. Y. Moriyama, T. Manabe, T. Yoshimori, Y. Tashiro, and M. Futai. ATP-dependent uptake of anti-neoplastic agents by acidic organelles, J. Biochem. Tokyo 115:213-218(1994).
9. M. J. Reason A review of the biology and toxicologic implications of the induction of lysosomal lamellar bodies by drugs. Toxicol. Appl. Pharmacol. 97:47-56 (1989).
10. H. Glaumann, A. M. Motakefi, and H. Jansson Intracellular distribution and effect of the antimalarial drug mefloquine on lysosomes of rat liver. Liver 12:183-190 (1992).
11. Y. Sai, and S. Ohkuma. Small GTP-binding proteins on rat liver lysosomal membranes. Cell Struct. Fund. 17:363-369 (1992).
12. K. Yokogawa, E. Nakashima, F. Ichimura, and T. Yaman Simultaneous microdetermination of biperiden, haloperidol, and trihexyphenidyl in plasma and its application to pharmacokinetic analysis after concomitant intravenous administration of the drugs to rabbits. Chem. Pharm. Bull. Tokyo. 33:4581-6 (1985).
13. R. Hori, K. Okumura, and H. Yoshida. Binding of basic drugs to rat lung mitochondria. Pharm. Res. 4:142-6 (1987).
14. B. Alberts, D. Bray, J. Lewis, M. Raff. K. Roberts, and J.D. Watson, "Mollecular Biology of THE CELL", 3rd ed., Chapter 3, Garland Publishing Inc., New York & London, 1994, pp.89-138.
15. B. Alberts, D. Bray, J. Lewis, M. Raff, K. Roberts, and J. D. Watson, "Mollecular Biology of THE CELL ", 3rd ed., Chapter 12, Garland Publishing Inc., New York & London, 1994, pp.551-598.