Ex vivo expansion of apheresis-derived peripheral blood hematopoietic progenitors

Journal of Clinical Apheresis

Volumn 17, Issue 1, 2002, Pages 7-16

  Ford, C D ^a   Lehman, C ^c   Strupp, A ^b   Kelley, L ^c  

^a LDS HOSPITAL   (United States)

^b AMERICAN RED CROSS   (United States)

^c UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD19 ANTIGEN; CD34 ANTIGEN; CD38 ANTIGEN; RECOMBINANT GRANULOCYTE COLONY STIMULATING FACTOR;

APHERESIS; ARTICLE; CANCER CHEMOTHERAPY; COLONY FORMING UNIT; COLONY FORMING UNIT GEMM; COLONY FORMING UNIT GM; HEMATOPOIETIC STEM CELL; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMAN; HUMAN CELL; IMMUNOPHENOTYPING; LIQUID CULTURE; MONONUCLEAR CELL; NEUTROPENIA; T LYMPHOCYTE;

ANIMALS; ANTIGENS, DIFFERENTIATION; CATTLE; CELL CULTURE TECHNIQUES; CELL LINEAGE; CELLS, CULTURED; COLONY-FORMING UNITS ASSAY; FETAL BLOOD; GRANULOCYTE COLONY-STIMULATING FACTOR; HEMATOPOIETIC STEM CELLS; HUMANS; IMMUNOPHENOTYPING; LEUKAPHERESIS; LYMPHOCYTES; MYELOID CELLS; STEM CELL FACTOR;

EID: 0036226650     PISSN: 07332459     EISSN: None     Source Type: Journal    
DOI: 10.1002/jca.10012     Document Type: Article

References (46)

1. Role of granulocyte-macrophage colony-stimulating factor as adjuvant treatment in neutropenic patients with bacterial and fungal infection
2. Effect of recombinant human granulocyte-macrophage colony-stimulating factor on hematopoietic reconstitution after high-dose chemotherapy and autologous stem cell rescue
3. Granulocyte colonystimulating factor after high-dose chemotherapy and autologous bone marrow transplantation
4. Successful autologous transplantation with peripheral blood hematopoietic cells in a patient with acute leukemia
5. Autologous transplantation of blood-derived hematopoietic stem cells after myeloablative therapy in a patient with Burkitt's lymphoma
6. Transplantation of allogeneic peripheral blood stem cells mobilized by recombinant human granulocyte colony-stimulating factor (G-CSF)
7. Source of stem cells impacts upon hematopoietic recovery after high-dose chemotherapy
8. Effect of peripheral blood progenitors mobilized by filgrastim (G-CSF) on platelet recovery after high-dose chemotherapy
9. Ex vivo expansion of neutrophil precursors and progenitors in suspension cultures of CD34+ cells enriched from human bone marrow
10. Expansion of neutrophil precursors and progenitors in suspension cultures of CD34+ enriched cells from human bone marrow
11. Production of functional myeloid cells from CD34-selected hematopoietic progenitor cells using a clinically relevant ex vivo expansion system
12. Studies of the function and structure of in vitro propagated human granulocytes
13. Neutrophil maturation of CD34+ cells from peripheral blood and bone marrow in serum-free culture medium with PIXY321 and granulocytecolony stimulating factor
14. Clinical applications of ex vivo cultured CD34+ cells and myeloid progenitors
15. Granuloerythropoietic colonies in human bone marrow, peripheral blood, and cord blood
16. Culture studies of human pluripotent hematopoietic progenitors
17. The ISHAGE guidelines for CD34+ Cell determination by flow cytometry
18. Cellular basis of chemotherapy
19. Autologous bone marrow transplantation as compared with standard salvage chemotherapy in relapses of chemotherapy-sensitive nonHodgkin's lymphoma
20. A prospective randomized trial of autologous bone marrow transplantation and chemotherapy in multiple myeloma
21. High-dose chemotherapy with hematopoietic rescue as primary treatment for metastatic breast cancer
22. Quantitative relationships between circulating leukocytes and infection in patients with acute leukemia
23. Purification of CD34+ cells is essential for optimal ex vivo expansion of umbilical cord blood cells
24. Characterization and transfusion of in vitro cultivated hematopoietic progenitor cells
25. Maturation of mobilized peripheral blood progenitor cells: Preclinical and phase I clinical studies
26. Ex vivo expansion and differentiation of unselected peripheral blood progenitor cells in serum-free media
27. CD34-positive cells isolated from cryopreserved peripheral-blood progenitor cells can be expanded ex vivo and used for transplantation with little or no toxicity
28. Abrogation of post-myeloablative chemotherapy neutropenia by ex-vivo expanded autologous CD34-positive cells
29. Ex Vivo expansion of PBPC maintains scid repopulating cells and provides rapid and durable engraftment in breast cancer patients
30. Selection of retrovirally transduced hematopoietic cells using CD24 as a marker of gene transfer
31. Enhanced marrow recovery by short pre-incubation of marrow allografts with IL-3 and GM-CSF
32. Ex vivo purging and cell expansion
33. Selection and expansion of peripheral blood CD34+ cells: Their clinical utility in autologous stem cell transplantation for breast cancer
34. Culture, expansion and differentiation of peripheral blood CD34+ cells in autologous stem cell transplantation for metastatic breast cancer
35. Impact of ex vivo expanded myeloid progenitors on neutropenia after high-dose chemotherapy
36. Ex vivo expansion of genetically marked rhesus peripheral blood progenitor cells results in diminished long-term repopulating ability
37. Engrafment of primates with G-CSF mobilized peripheral blood CD34 + progenitor cells expanded in G-CSF, SCF and MGDF decreases the duration and severity of neutropenia
38. Murine marrow cells expanded in culture with IL-3, IL-6, IL-11, and SCF acquire an engraftment defect in normal hosts
39. Engraftment of bone marrow cells into normal unprepared hosts: Effects of 5-fluorouracil and cell cycle status
40. Maintenance of murine long-term repopulating stem cells in ex vivo culture is affected by modulation of transforming growth factor-(but not macrophage inflammatory protein-1) activities
41. Ability of early acting cytokines to directly promote survival and suppress apoptosis of human primitive CD34+ CD38-bone marrow cells with multilineage potential at the single cell level: Key role of thrombopoietin
42. Thrombopoietin directly and potently stimulates multilineage growth and progenitor cell expansion from primitive CD34+ CD38-human bone marrow progenitor cells: Distinct and key interactions with the ligands for c-kit and flt3, and inhibitory effects of TGF-beta and TNF-alpha
43. Quantitative analysis reveals expansion of human hematopoietic repopulating cells after short-term ex vivo culture
44. CD34(+) cells from mobilized peripheral blood retain fetal bone marrow repopulating capacity within the Thy-1(+) subset following cell division ex vivo
45. Adhesion receptors of the immune system
46. Expression of N-CAM (CD56) on acute leukemia cells: Relationship with disease characteristics and outcome