Comparison of apolipoprotein B metabolism in familial defective apolipoprotein B and heterogeneous familial hypercholesterolemia

Atherosclerosis

Volumn 162, Issue 1, 2002, Pages 33-43

  Gaffney, Dairena ^a   Forster, Lorne ^a   Caslake, Muriel J ^a   Bedford, Dorothy ^a   Stewart, J Philip ^a   Stewart, Grace ^a   Wieringa, Gilbert ^b   Dominiczak, Marek ^c   Miller, J Paul ^d   Packard, Chris J ^a  

^a GLASGOW ROYAL INFIRMARY   (United Kingdom)

^b CHRISTIE HOSPITAL   (United Kingdom)

^c GARTNAVEL GENERAL HOSPITAL   (United Kingdom)

^d MANCHESTER UNIVERSITY NHS FOUNDATION TRUST   (United Kingdom)

Author keywords

Apolipoprotein B 100; Deuterated leucine; Homozygous FDB; Hypercholesterolemia; Kinetic multicompartmental modelling

Indexed keywords

APOLIPOPROTEIN B; DEUTERIUM; INTERMEDIATE DENSITY LIPOPROTEIN; LEUCINE; LOW DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN RECEPTOR; TRACER; TRIACYLGLYCEROL; VERY LOW DENSITY LIPOPROTEIN;

ADULT; ARTICLE; BIOLOGICAL MODEL; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE SEVERITY; FAMILIAL DEFECTIVE APOLIPOPROTEIN B; FAMILIAL DISEASE; FAMILIAL HYPERCHOLESTEROLEMIA; GENETIC HETEROGENEITY; HETEROZYGOSITY; HOMOZYGOSITY; HUMAN; KINETICS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BLOOD LEVEL; PROTEIN INTERACTION; PROTEIN METABOLISM; PROTEIN SYNTHESIS; REGULATORY MECHANISM; TRIACYLGLYCEROL BLOOD LEVEL;

ABETALIPOPROTEINEMIA; ADULT; APOLIPOPROTEINS B; CHOLESTEROL; CHOLESTEROL, HDL; CHOLESTEROL, LDL; CHOLESTEROL, VLDL; FAMILY HEALTH; GENETIC HETEROGENEITY; GENETIC MARKERS; HOMOZYGOTE; HUMANS; HYPERLIPOPROTEINEMIA TYPE II; LIPOPROTEINS; MIDDLE AGED; RECEPTORS, LDL; SCOTLAND; TRIGLYCERIDES;

EID: 0036224071     PISSN: 00219150     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0021-9150(01)00679-7     Document Type: Article

References (30)

1. Plasma lipoproteins: Apolipoprotein structure and function
2. Familial defective apolipoprotein B-100: A review including some comparisons with familial hypercholesterolaemia
3. Familial defective apolipoprotein B-100: A study of patients from lipid clinics in Scotland and Wales
4. Phenotypic variation in patients heterozygous for familial defective apolipoprotein B (FDB) in three European countries
5. Molecular genetics of the LDL receptor gene in familial hypercholesterolemia
6. A World Wide Web site for low-density lipoprotein receptor gene mutations in familial hypercholesterolemia: Sequence-based, tabular, and direct submission data handling
7. Association between a specific apolipoprotein B mutation and familial defective apolipoprotein B-100
8. Independent mutations at codon 3500 of the apolipoprotein B gene are associated with hyperlipidemia
9. The apolipoprotein B R3531C mutation. Characteristics of 24 subjects from 9 kindreds
10. Receptor-mediated low density lipoprotein catabolism in man
11. The metabolism of very low density and intermediate density lipoproteins in patients with familial hypercholesterolaemia
12. Increased hepatic secretion of very-low-density-lipoprotein apolipoprotein B-100 in heterozygous familial hypercholesterolaemia: A stable isotope study
13. Apolipoprotein B metabolism in homozygous familial hypercholesterolemia
14. Increased clearance of low density lipoprotein precursors in patients with heterozygous familial defective apolipoprotein B-100: A stable isotope approach
15. VLDL and IDL apolipoprotein B-100 kinetics in familial hypercholesterolemia due to impaired LDL receptor function or to defective apolipoprotein B-100
16. Homozygous familial defective apolipoprotein B-100. Enhanced removal of apolipoprotein E-containing VLDLs and decreased production of LDLs
17. Identification of a patient homozygous for familial defective apolipoprotein B (FDB)
18. Risk of fatal coronary heart disease in familial hypercholesterolaemia
19. Apolipoprotein B metabolism and the distribution of VLDL and LDL subfractions
20. Using mutagenic polymerase chain reaction primers to detect carriers of familial defective apolipoprotein B-100
21. Rapid testing for three mutations causing familial defective apolipoprotein B100 in 562 patients with familial hypercholesterolaemia
22. A rapid micromethod for apolipoprotein E phenotyping directly in serum
23. Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with HhaI
24. The isolation and quantitation analysis of serum lipoproteins
25. Sensitive methods to study human apolipoprotein B metabolism using stable isotope-labeled amino acids
26. Isopropanol precipitation method for the determination of apolipoprotein B specific activity and plasma concentrations during metabolic studies of very low density lipoprotein and low density lipoprotein apolipoprotein B
27. Protein measurement with the Folin phenol reagent
28. Overproduction of small very low density lipoproteins (Sf 20-60) in moderate hypercholesterolemia: Relationships between apolipoprotein B kinetics and plasma lipoproteins
29. Metabolism of apolipoprotein B in large triglyceride-rich very low density lipoproteins of normal and hypertriglyceridemic subjects