Immunoregulation of IL-6 secretion by endogenous and exogenous adenosine and by exogenous purinergic agonists in splenic tissue slices

Journal of Neuroimmunology

Volumn 125, Issue 1-2, 2002, Pages 73-81

  Straub, Rainer H ^a   Pongratz, Georg ^a   Günzler, Christian ^a   Michna, Andreas ^a   Baier, Simone ^a   Kees, Frieder ^a   Falk, Werner ^a   Schölmerich, Jürgen ^a  

^a UNIVERSITY HOSPITAL REGENSBURG   (Germany)

Author keywords

Adenosine; ATP; IL 6; Splenic macrophage; Sympathetic nerve

Indexed keywords

2 [4 (2 CARBOXYETHYL)PHENETHYLAMINO]ADENOSINE 5' (N ETHYLCARBOXAMIDE); 2 METHYLTHIOADENOSINE TRIPHOSPHATE; 8 (3 CHLOROSTYRYL)CAFFEINE; 8 CYCLOPENTYL 1,3 DIPROPYLXANTHINE; ADENOSINE; ADENOSINE A1 RECEPTOR; ADENOSINE A1 RECEPTOR ANTAGONIST; ADENOSINE A2 RECEPTOR ANTAGONIST; BETA,GAMMA METHYLENEADENOSINE TRIPHOSPHATE; HYDROCORTISONE; INTERLEUKIN 6; PURINERGIC RECEPTOR STIMULATING AGENT;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; DRUG EFFECT; ELECTROSTIMULATION; FEMALE; IMMUNOREGULATION; LYMPHOID ORGAN; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; REDUCTION; SPLEEN; SYMPATHETIC NERVE;

ADENOSINE TRIPHOSPHATE; ADRENERGIC ALPHA-AGONISTS; ANIMALS; CAFFEINE; ELECTRIC STIMULATION; FEMALE; INTERLEUKIN-6; MACROPHAGES; MICE; MICE, INBRED STRAINS; NEUROIMMUNOMODULATION; NOREPINEPHRINE; RECEPTORS, PURINERGIC P2; SPLEEN; SYMPATHETIC NERVOUS SYSTEM; THIONUCLEOTIDES;

EID: 0036224042     PISSN: 01655728     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-5728(02)00035-8     Document Type: Article

References (61)

1. Differential regulation of vascular smooth muscle nuclear factor kappa-B by G alpha q-coupled and cytokine receptors
2. Evidence that G alpha(q)-coupled receptor-induced interleukin-6 mRNA in vascular smooth muscle cells involves the nuclear factor of activated T cells
3. Differential regulation of IL 6, IL 1 A, IL 1 beta and TNF alpha production in LPS-stimulated human monocytes: Role of cyclic AMP
4. Innervation of lymphoid organs - Association of nerves with cells of the immune system and their implications in disease
5. Immune-neuro-endocrine interactions
6. Localization of adrenaline in cytoplasmic particles of the bovine adrenal medulla
7. Differential regulatory effects of adenosine on cytokine release by activated human monocytes
8. Adenosine receptor interactions and anxiolytics
9. A basis for distinguishing two types of purinergic receptor
10. The antiinflammatory effects of an adenosine kinase inhibitor are mediated by adenosine
11. Modulation of glucocorticoid receptor expression in human articular chondrocytes by cAMP and prostaglandins
12. Adenosine-deaminase deficiency and combined immunodeficiency syndrome
13. P2 receptors meet the immune system
14. The mechanism of cAMP-induced glucocorticoid receptor expression. Correlation to cellular glucocorticoid response
15. The sympathetic nerve - An integrative interface between two supersystems: The brain and the immune system
16. Adenosine receptors are expressed during differentiation of monocytes to macrophages in vitro. Implications for regulation of phagocytosis
17. Noradrenergic sympathetic neural interactions with the immune system: Structure and function
18. Extracellular ATP triggers IL-1 beta release by activating the purinergic P2Z receptor of human macrophages
19. The P2 purinergic receptors of human dendritic cells: Identification and coupling to cytokine release
20. Adenosine A2b receptors mediate an increase in interleukin (IL)-6 mRNA and IL-6 protein synthesis in human astroglioma cells
21. Effect of adenosine receptor agonists and other compounds on cyclic AMP accumulation in forskolin-treated hippocampal slices
22. Adenosine-deaminase deficiency in two patients with severely impaired cellular immunity
23. Cyclic AMP-dependent protein kinase promotes glucocorticoid receptor function
24. Titratable effects of p-chloromercuriphenyl sulfonate, a thiol-attacking reagent, on glucocorticoid receptor binding
25. Extracellular ATP triggers tumor necrosis factor-alpha release from rat microglia
26. Engraftment of gene-modified umbilical cord blood cells in neonates with adenosine deaminase deficiency
27. Interaction between glucocorticoids and beta2-agonists: Alpha and beta glucocorticoid-receptor mRNA expression in human bronchial epithelial cells
28. Extracellular ATP induces a distorted maturation of dendritic cells and inhibits their capacity to initiate Th1 responses
29. Purinergic systems
30. Catecholamines, sympathetic nerves, and immunity
31. Characterization of a specific adenosine receptor on human lymphocytes
32. Glucocorticoid physiology, pharmacology and stress
33. Interleukin-6 production by astrocytes: Induction by the neurotransmitter norepinephrine
34. Modulation of glucocorticoid receptor activity by cyclic nucleotides and its implications on the regulation of human skin fibroblast growth and protein synthesis
35. Direct effects of interleukin-6 on human adrenal cells
36. Adenosine increases interleukin 6 release and decreases tumour necrosis factor release from rat adrenal zona glomerulosa cells, ovarian cells, anterior pituitary cells, and peritoneal macrophages
37. Disturbed immune-endocrine communication in autoimmune disease. Lack of corticosterone response to immune signals in obese strain chickens with spontaneous autoimmune thyroiditis
38. Beta(2)-adrenergic receptors potentiate glucocorticoid receptor transactivation via g protein betagamma-subunits and the phosphoinositide 3-kinase pathway
39. Stimulation of interleukin-6 secretion and gene transcription in primary astrocytes by adenosine
40. Demonstration of adenosine receptor on human lymphocytes in vitro and its possible role in the adenosine deaminase-deficient form of severe combined immunodeficiency
41. Co-transmission
42. Human primary fibroblasts in vitro express a purinergic P2X7 receptor coupled to ion fluxes, microvesicle formation and IL-6 release
43. A central nervous system defect in biosynthesis of corticotropin-releasing hormone is associated with susceptibility to streptococcal cell wall-induced arthritis in Lewis rats
44. The rat testicular A1 adenosine receptor-adenylate cyclase system
45. In vitro superfusion method for the investigation of nerve-immune cell interaction in murine spleen
46. Neuroimmune control of interleukin-6 secretion in the murine spleen. Differential-adrenergic effects of electrically released endogenous norepinephrine under various endotoxin conditions
47. Neuronal regulation of interleukin 6 secretion in murine spleen: Adrenergic and opioidergic control
48. Dialogue between CNS and immune system in lymphoid organs
49. Tonic neurogenic inhibition of interleukin-6 secretion from murine spleen caused by opioidergic transmission
50. Neuropeptide Y cotransmission with norepinephrine in the sympathetic nerve-macrophage interplay
51. A bacteria-induced switch of sympathetic effector mechanisms augments local inhibition of TNF-alpha and IL-6 secretion in the spleen
52. ATP-stimulated Ca2+ influx and phospholipase D activities of a rat brain-derived type-2 astrocyte cell line, RBA-2, are mediated through P2X7 receptors
53. Evidence for the differential release of the cotransmitters ATP and noradrenaline from sympathetic nerves of the guinea-pig vas deferens
54. Neuronal release of soluble nucleotidases and their role in neurotransmitter inactivation
55. Origin of ATP release in the rat vas deferens: Concomitant measurement of [3H]noradrenaline and [14C]ATP
56. Noradrenaline and adenosine triphosphate as co-transmitters of neurogenic vasoconstriction in rabbit mesenteric artery
57. Role of sympathetic nerves for the stimulation of the renin system by angiotensin II receptor blockade
58. Differential regulation of cardiac expression of IL-6 and TNF-alpha by A2- and A3-adenosine receptors
59. Synthesis of interleukin-6 (interferon-beta2/B cell stimulatory factor 2) in human fibroblasts is triggered by an increase in intracellular cyclic AMP