Diminished Th1 and Th2 cytokine production in healthy adult nonresponders to recombinant hepatitis B vaccine

Scandinavian Journal of Immunology

Volumn 55, Issue 3, 2002, Pages 311-314

  Kardar, G A ^a   Jeddi Tehrani, M ^a,b   Shokri, F ^a,c  

^a TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b Avesina Research Institute   (Iran)

^c PASTEUR INSTITUTE OF IRAN   (Iran)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; HEBERBIOVAC; HEPATITIS B SURFACE ANTIGEN; INTERLEUKIN 10; INTERLEUKIN 2; PHYTOHEMAGGLUTININ; RECOMBINANT HEPATITIS B VACCINE;

ADULT; ANTIBODY RESPONSE; ARTICLE; CELL ISOLATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IN VITRO STUDY; IRAN; MALE; MONONUCLEAR CELL; NORMAL HUMAN; PRIORITY JOURNAL; TH1 CELL; TH2 CELL; VACCINATION;

ADULT; CYTOKINES; FEMALE; HEPATITIS B SURFACE ANTIGENS; HEPATITIS B VACCINES; HUMANS; IMMUNE TOLERANCE; INTERFERON TYPE II; INTERLEUKIN-10; INTERLEUKIN-2; LYMPHOCYTE ACTIVATION; MALE; PHYTOHEMAGGLUTININS; TH1 CELLS; TH2 CELLS; VACCINES, DNA;

EID: 0036223592     PISSN: 03009475     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-3083.2002.01057.x     Document Type: Article

References (27)

1. Update on diagnosis, management and prevention of hepatitis B virus infection
2. Hepatitis B: Epidemiology, natural history, biology and treatment monitoring
3. Expanded programme on immunization
4. High seroprotection rate induced by low doses of a recombinant hepatitis B vaccine in healthy Iranian neonates
5. High rate of seroconversion following administration of a single supplementary dose of recombinant hepatitis B vaccine in Iranian healthy nonresponder neonates
6. Revaccination against hepatitis B virus of non-responding and low-responding infants immunized at birth. A parallel evaluation of rubella and tetanus vaccine
7. Defect in TH1-like cells of nonresponders to hepatitis B vaccine
8. Enumeration of HBsAg-specific B lymphocytes in Iranian healthy adult responders and non-responders vaccinated with recombinant HBV vaccine
9. HLA-associated antibody response to recombinant hepatitis B vaccine in healthy Iranian adults
10. Response to hepatitis B vaccine: Multiple HLA genes are involved
11. Selective killing of hepatitis B envelope antigen-specific B-cells by class I-restricted, exogenous antigen-specific T-lymphocytes
12. Failure of neonatal hepatitis B vaccination: The role of HBV DNA levels in hepatitis B carrier mothers and HLA in neonates
13. Is a function of the secreted HBe antigen to induce immunological tolerance in utero
14. Altered helper T lymphocyte function associated with chronic hepatitis B virus infection and its role in response to therapeutic vaccination in humans
15. Deficient T-cell responses in non-responders to hepatitis B vaccination: Absence of TH1 cytokine production
16. Complex cytokine responses to hepatitis B surface antigen and tetanus toxid in responders, nonresponders and subjects naive to hepatitis B surface antigen
17. The Th1/Th2 paradigm
18. Cytokines induce the development of functionally heterogeneous T helper cell subsets
19. Protection or damage: A dual role for the virus-specific cytotoxic T lymphocyte response in hepatitis B and C virus
20. The expanding universe of T cell subsets: Th1, Th2 and more
21. Antiviral cell mediated immune responses during hepatitis B and hepatitis C virus infection
22. Kinetics of hepatitis B surface antigen-specific immune responses in acute and chronic hepatitis B or after HBs vaccination: Stimulation of the in vitro antibody response by interferon gamma
23. +-cloned T cells
24. + T-lymphocyte clones induced by vaccination with rHBsAg vaccine
25. Comparative analysis of HLA restriction and cytokine production in hepatitis B surface antigen-specific T cells from low-and high-antibody responders in vaccinated humans
26. Nonresponders to hepatitis B vaccine can present envelope particles to T lymphocytes
27. Normal HBsAg presentation and T-cell defect in the immune response of nonresponders