The amphiphilic properties of novenamines determine their activity as inhibitors of HIV-1 RNase H

Experientia

Volumn 52, Issue 4, 1996, Pages 329-335

  Althaus, I W ^a   Franks, K M ^a   Langley, K B ^a   Kezdy F J ^a   Peterson, T ^a   Buxer, S E ^a   Decker, D E ^a   Dolak, L A ^a   Ulrich, R G ^a   Reusser, F ^a  

^a PFIZER INC   (United States)

Author keywords

HIV RNase H; Inhibitors; Micelles; Novenamines

Indexed keywords

AMINE; AMPHOPHILE; ESTERASE INHIBITOR; MONOMER; RIBONUCLEASE H; RNA DIRECTED DNA POLYMERASE;

AQUEOUS SOLUTION; ARTICLE; DOSE RESPONSE; DRUG DELIVERY SYSTEM; HUMAN IMMUNODEFICIENCY VIRUS 1; IONIZATION; MICELLE; NONHUMAN; PH; PKA; PROTON TRANSPORT;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 9244250361     PISSN: 00144754     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF01919535     Document Type: Article

References (18)

1. Gellert, M., A. Rev. Biochem. 50 (1981) 879.
2. Reusser, F, and Dolak, L. A., J. Antibiotics 39 (1986) 272.
3. Althaus, I. W., Dolak, L. A., and Reusser, F., J. Antibiotics 41 (1988) 373.
4. Kezdy, F. J., in: Membrane Molecular Biology, pp. 123-145. Eds. C. F. Fox and A. D. Keith, Sinauer Ass. Inc., Publishers, Stamford, Conneticut 1972.
5. Tanford, C., The Hydrophobic Effect: Formation of Micelles and Biological Membranes, J. Wiley and Sons, New York-London-Sydney-Toronto 1973.
6. Tate, M. W., Eikenberry, E. F. Turner, D. C., Shyamsunder, E., and Gruner, S. M. Chem. Phys. Lipids 57 (1991) 147.
7. Dolak, L. A., United States Patent # 3,890,2977 (1975).
8. Althaus, I. W., LeMay, R. J., Gonzales, A. J., Deibel, M. R., Sharma, S. K., Kezdy, F. J., Resnick, L., Busso, M. E., Aristoff, P. A., and Reusser, F.,Experientia 48 (1992) 1127.
9. S. Arnott, Chandrasekaran, R., Millane, R. P., and Park, H. S., J. molec. Biol. 188 (1986) 631.
10. Zhan, X., Tan, C. K., Scott, W. A., Mian, A. M., Downey, K. M., and So, A. G., Biochemistry 33 (1994) 1366.
11. Davies, J. F., Hostomska, Z., Hostomsky, Z., Jordan, S. R., Matthews, D. A., Ogden, R. C., Varney, M. D., and Stephen, S. E., (1992) PCT Int. Appl. 17182.
12. Smith, J. S., and Roth, M. J., J. Virol. 67 (1993) 4037.
13. Tan, C. K., Zhang, J., Li, Z. Y., Tarpley, W. G., Downey, K. M., and So, A. G., Biochemistry 30 (1991) 2651.
14. Lova, S., and Hizi, A., J. biol. Chem. 268 (1993) 9323.
15. Hafkemeyer, P., Neftel, K., Hobi, R., Pfaltz, A., Lutz, H., Luethy, K., Focher, F., Spadari, S., and Huebscher, U., Nucleic Acids Res. 19 (1991) 4059.
16. Vonsover, A., Loya, S., Sredni, S., Albeck, M., Gotlieb-Stematsky, T., Araf, O., and Hizi, A., AIDS Res. hum. Retroviruses 8 (1992) 613.
17. Tan, C. K., Civil, R., Mian, M. A., So, A. G., and Downey, K. M., Biochemistry 30 (1991) 4831.
18. Moelling, K., Schulze, T., and Diringer, H., J. Virol. 63 (1989) 5489.