Lung expression of cytochrome P450 1A1 as a possible biomarker of exposure to diesel exhaust particles

Archives of Toxicology

Volumn 76, Issue 3, 2002, Pages 146-151

  Takano, Hirohisa ^a,b,c   Yanagisawa, Rie ^a,c   Ichinose, Takamichi ^d   Sadakane, Kaori ^d   Inoue, Ken Ichiro ^a,e   Yoshida, Sei Ichi ^c   Takeda, Ken ^c,f   Yoshino, Shin ^f,g   Yoshikawa, Toshikazu ^b   Morita, Masatoshi ^a  

^a NATIONAL INSTITUTE FOR ENVIRONMENTAL STUDIES   (Japan)

^b KYOTO PREFECTURAL UNIVERSITY OF MEDICINE   (Japan)

^c JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^d OITA UNIVERSITY OF NURSING AND HEALTH SCIENCES   (Japan)

^e Kyoto Prefectural University of Medicine   (Japan)

^f TOKYO UNIVERSITY OF SCIENCE   (Japan)

^g KOBE PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

Biomarker; Cytochrome P450 1A1; Diesel exhaust particles; Lung injury; Polycyclic aromatic hydrocarbons

Indexed keywords

BIOLOGICAL MARKER; CHARCOAL; CYTOCHROME P450 1A1; DIESEL FUEL; POLYCYCLIC AROMATIC HYDROCARBON; REACTIVE OXYGEN METABOLITE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISEASE MARKER; EXHAUST GAS; INHALATION; LUNG TOXICITY; MALE; MOLECULE; MOUSE; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RESPIRATORY TRACT DISEASE;

ANIMALS; BIOLOGICAL MARKERS; CYTOCHROME P-450 CYP1A1; DOSE-RESPONSE RELATIONSHIP, DRUG; INHALATION EXPOSURE; INTUBATION, INTRATRACHEAL; LUNG; MALE; MICE; MICE, INBRED ICR; MICROSOMES; POLYMERASE CHAIN REACTION; RECEPTORS, ARYL HYDROCARBON; RNA, MESSENGER; VEHICLE EMISSIONS;

ANIMALIA; MURINAE;

EID: 0036216522     PISSN: 03405761     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00204-002-0323-0     Document Type: Article

References (35)

1. Relationship between hydrocarbon structure and induction of P450: Effects of protein levels and enzyme activities
2. Contribution of hepatic cytochrome P450 systems to the generation of reactive oxygen species
3. Aryl hydrocarbon receptor imported into the nucleus following ligand binding is rapidly degraded via the cytoplasmic proteasome following nuclear export
4. Pregnenolone-7β-hydroxylating activities of yeast-expressed mouse cytochrome P450-1A1 and mouse-tissue microsomes
5. Quantitation of nitro and dinitropolycyclic aromatic hydrocarbons in diesel exhaust particulate matter
6. Developmental onset of mixed-function oxidase activity in preimplantation mouse embryos
7. Cultured mouse embryos metabolize benzo[a]pyrene during early gestation: Genetic differences detectable by sister chromatid exchange
8. On road sampling of diesel engine emissions of polychlorinated dibenzo-p-dioxin and polychlorinated dibenzofuran
9. Exposure to various benzene derivatives differently induces cytochromes P450 2B1 and 2E1 in rat liver
10. The aryl hydrocarbon receptor: A comparative perspective
11. Exposure to diesel exhaust exacerbates allergen-induced asthmatic responses in guinea pigs
12. The role of a mitochondrial pathway in the induction of apoptosis by chemicals extracted from diesel exhaust particles
13. Biological effects of diesel exhaust particles (DEP) II. Acute toxicity of DEP introduced in lung by intratracheal instillation
14. Induction of cytochrome P450 isozymes in rat liver by methyl n-alkyl ketones and n-alkylbenzenes. Effects of hydrophobicity of inducers on inducibility of cytochrome P450
15. Generation of reactive oxygen species during interaction of diesel exhaust particle components with NADPH-cytochrome P450 reductase and involvement of the bioactivation in the DNA damage
16. Oxidase and oxygenase function of the microsomal cytochrome P450 monooxygenase system
17. Health effects of exposure to diesel exhaust particles
18. Diesel exhaust enhances allergic airway inflammation and hyperresponsiveness in mice
19. Drug-metabolizing enzymes in ligand-modulated transcription
20. Cytochrome P450 and the individuality of species
21. Induction of cytochrome P450 1A1 and 1A2 by hyperoxia
22. Production of reactive oxygen species by microsomes enriched in specific human cytochrome P450 enzymes
23. Cytochrome P450 mRNA expression in human liver and its relationship with enzyme activity
24. Upregulation and modulation of inducible nitric oxide synthesis in rat cardiac allografts with chronic rejection and transplant arteriosclerosis
25. Biological effect of diesel exhaust particles. I. In vitro production of superoxide and in vivo toxicity in mouse
26. Biological effects of diesel exhaust particles (DEP). III. Pathogenesis of asthma-like symptoms in mice
27. Sampling of vehicle emissions for chemical analysis and biological testing
28. Bioassay-directed chemical analysis in environmental research
29. Diesel exhaust particles enhance antigen-induced airway inflammation and local cytokine expression in mice
30. Diesel exhaust particles enhance airway responsiveness following allergen exposure in mice
31. Inhalation of diesel exhaust enhances allergen-induced eosinophil recruitment and airway hyperresponsiveness in mice
32. Enhanced human IgE production results from exposure to the aromatic hydrocarbons from diesel exhaust: Direct effects of B-cell IgE production
33. Ethylbenzene
34. The source of apportionment evolution of ambient particulate matter in Tokyo Metropolitan area by a receptor oriental model
35. Ethylbenzene modulates the expression of different cytochrome P450 isozymes by discrete multistep processes