Mitochondrial destabilisation and caspase-3 activation are involved in the apoptosis of Jurkat cells induced by gaudichaudione A, a cytotoxic xanthone

Planta Medica

Volumn 68, Issue 3, 2002, Pages 198-203

  Wu, Xiaohua ^a   Cao, Shugeng ^a   Goh, Sweehock ^a   Hsu, Anne ^a   Tan, Benny K H ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

Annexin V; Apoptosis; Caspases; Flow cytometry; Gaudichaudione A; Mitochondrial transmembrane potential

Indexed keywords

CYTOTOXIC AGENT; DNA FRAGMENT; GAUDICHAUDIONE A; UNCLASSIFIED DRUG; XANTHONE DERIVATIVE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CONTROLLED STUDY; DRUG CYTOTOXICITY; ENZYME ACTIVATION; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; MEMBRANE POTENTIAL; MITOCHONDRION;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; BRIDGED COMPOUNDS; CASPASE 3; CASPASES; DNA FRAGMENTATION; DOSE-RESPONSE RELATIONSHIP, DRUG; GARCINIA; HUMANS; JURKAT CELLS; MEMBRANE POTENTIALS; MICE; MICROSCOPY, ELECTRON; MITOCHONDRIA; PLANT EXTRACTS; TUMOR CELLS, CULTURED; XANTHENES; XANTHONES;

GARCINIA; MURINAE;

EID: 0036212473     PISSN: 00320943     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2002-23142     Document Type: Article

References (18)

1. Shikonin, An ingredient of Lithospermum erythrorhizon induced apoptosis in HL60 human premyelocytic leukemia cell line
2. 2+ influx in the mechanism of tamoxifen-induced apoptosis in HepG2 human hepatoblastoma cells
3. Apoptosis in the pathogenesis and treatment of disease
4. Mitochondrial control of apoptosis
5. Cleavage of poly(ADP-ribose)polymerase by a protease with properties like ICE
6. Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase
7. Caspase-3 is required for DNA fragmentation and morphological changes associated with apoptosis
8. Emerging roles of caspase-3 in apoptosis
9. Chemopreventive agent resveratrol, a natural product derived from grape, triggers CD95 signaling-dependent apoptosis in human tumor cells
10. Cytotoxic xanthones from Garcinia hanburyi
11. Xanthones from Guttiferae
12. Cytotoxic caged tetraprenylated xanthonoids from Garcinia gaudichaudii (Guttiferae)
13. Effects of cis-unsaturated fatty acids on doxorubicin sensitivity in P388/DOX resistant and P388 parental cell lines
14. A mitochondrial membrane protein defined by a novel monoclonal antibody is preferentially detected in apoptotic cells
15. Caspase-3 is required for DNA fragmentation and morphological changes associated with apoptosis
16. Essential contribution of caspase 3/CPP32 to apoptosis and its associated nuclear changes
17. The mitochondrial death/life regulator in apoptosis and necrosis
18. The permeability transition pore as a mitochondrial calcium release channel: A critical appraisal