Does ester hydrolysis change the in vitro degradation rate of cisatracurium and atracurium?

British Journal of Anaesthesia

Volumn 88, Issue 4, 2002, Pages 555-562

  Weindlmayr Goettel, M ^a   Gilly, H ^a,b   Kress, H G ^a,b  

^a UNIVERSITY OF VIENNA   (Austria)

^b LUDWIG BOLTZMANN INSTITUTE FOR LUNG VASCULAR RESEARCH   (Austria)

Author keywords

Metabolism, ester hydrolysis; Metabolism, Hofmann elimination; Neuromuscular block, atracurium; Neuromuscular block, cisatracurium

Indexed keywords

ATRACURIUM; BIS(4 NITROPHENYL) PHOSPHATE; BUFFER; CARBOXYLESTERASE; CISATRACURIUM; DRUG METABOLITE; ESTER DERIVATIVE; ESTERASE; ESTERASE INHIBITOR; LAUDANOSINE; PHOSPHATE;

AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG DEGRADATION; DRUG ELIMINATION; DRUG STRUCTURE; ENZYME ACTIVITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROLYSIS; IN VITRO STUDY; INCUBATION TIME; PH; PRIORITY JOURNAL; TEMPERATURE;

EID: 0036211229     PISSN: 00070912     EISSN: None     Source Type: Journal    
DOI: 10.1093/bja/88.4.555     Document Type: Article

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