In vitro degradation of atracurium and cisatracurium at pH 7.4 and 37°C depends on the composition of the incubating solutions

British Journal of Anaesthesia

Volumn 81, Issue 3, 1998, Pages 409-414

  Weindlmayr Goettel, Marta ^a,d   Kress, Hans Georg ^b   Hammerschmidt, Friedrich ^a   Nigrovic, Vladimir ^c  

^a UNIVERSITY OF VIENNA   (Austria)

^b LUDWIG BOLTZMANN INSTITUTE FOR LUNG VASCULAR RESEARCH   (Austria)

^c MEDICAL COLLEGE OF OHIO   (United States)

^d Department ^*  (Austria)

Author keywords

Neuromuscular block, atracurium; Neuromuscular block, cisatracurium; Pharmacokinetics, atracurium; Pharmacokinetics, cisatracurium

Indexed keywords

4 (2 HYDROXYETHYL) 1 PIPERAZINEETHANESULFONIC ACID; ATRACURIUM; ATRACURIUM BESILATE; BUFFER; CISATRACURIUM; GLUCOSE; LAUDANOSINE; PHOSPHATE; POTASSIUM; SODIUM CHLORIDE; TROMETAMOL;

ARTICLE; DRUG DEGRADATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ISOMER; MATHEMATICAL MODEL; PH; PRIORITY JOURNAL; STEREOISOMERISM; TEMPERATURE; TIME;

EID: 0031712204     PISSN: 00070912     EISSN: None     Source Type: Journal    
DOI: 10.1093/bja/81.3.409     Document Type: Article

References (10)

1. Tsui D, Graham GG, Torda TA. The pharmacokinetics of atracurium isomers in vitro and in humans. Anesthesiology 1987; 67: 722-728.
2. Welch RM, Brown A, Ravitch J, Dahl R. The in vitro degradation of cisatracurium, the R,-cis-R'-isomer of atracurium, in human and rat plasma. Clinical Pharmacology and Therapeutics 1995; 58: 132-142.
3. Merrett RA, Thompson CW, Webb FW. In vitro degradation of atracurium in human plasma. British Journal of Anaesthesia 1983; 55: 61-66.
4. Stiller RL, Cook DR, Chakravorti S. In vitro degradation of atracurium in human plasma. British Journal of Anaesthesia 1985; 57: 1085-1088.
5. Saunders WH jr. Ionic Aliphatic Reactions. Englewood Cliffs: NJ Prentice-Hall, 1965; 55-76.
6. Nigrovic V, Banoub M. Pharmacokinetic model of a parent drug and its metabolite: atracurium and laudanosine. Clinical Pharmacokinetics 1992; 22: 396-408.
7. Kisor DF, Schmith VD, Wargin WA, Lien CA, Ornstein E, Cook DR. Importance of the organ-independent elimination of cisatracurium. Anesthesia and Analgesia 1996; 83: 1065-1071.
8. Weast RC, ed. CRC Handbook of Chemistry and Physics, 47th Edn. Cleveland, OH:The Chemical Rubber Co., 1966; D-87
9. Sigma Chemical Company. Catalogue 1995. St Louis, MO, USA, 1995; 1685.
10. Fisher DM, Canfell PC, Fahey MR, Rosen JI, Rupp SM, Sheiner LB, Miller RD. Elimination of atracurium in humans: Contribution of Hofrnann elimination and ester hydrolysis versus organ-based elimination. Anesthesiology 1986; 65: 6-12.