Antifungal mechanism of FK463 against Candida albicans and Aspergillus fumigatus

Journal of Antibiotics

Volumn 55, Issue 2, 2002, Pages 219-222

  Hatano, Kazuo ^a   Morishita, Yoshihiko ^a   Nakai, Toru ^a   Ikeda, Fumiaki ^a  

^a ASTELLAS PHARMA INC   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

5 FC; ANTIFUNGAL AGENT; BENANOMICIN A; BETA 1,3 GLUCAN; BLASTICIDIN S; CHITIN; CILOFUNGIN; DNA; ECHINOCANDIN; MANNAN; MICAFUNGIN; NIKKOMYCIN; NUCLEIC ACID SYNTHESIS INHIBITOR; PNEUMOCANDIN DERIVATIVE; POLYENE; PROTEIN SYNTHESIS INHIBITOR; PYRROLE DERIVATIVE; RNA; SORDARIN DERIVATIVE; UNCLASSIFIED DRUG;

ANTIFUNGAL ACTIVITY; ARTICLE; ASPERGILLUS FUMIGATUS; BACTERIUM CULTURE; CANDIDA ALBICANS; CARBOHYDRATE SYNTHESIS; CHEMICAL REACTION KINETICS; CONTROLLED STUDY; DNA SYNTHESIS; DRUG DETERMINATION; IC 50; INCUBATION TIME; INHIBITION KINETICS; NONHUMAN; NUCLEIC ACID SYNTHESIS; PRIORITY JOURNAL; PROTEIN SYNTHESIS; RNA SYNTHESIS;

ASPERGILLUS FUMIGATUS; CANDIDA ALBICANS;

EID: 0036209847     PISSN: 00218820     EISSN: None     Source Type: Journal    
DOI: 10.7164/antibiotics.55.219     Document Type: Article

References (13)

1. Treatment of fungal and other opportunistic infections in immunocompromised patients
2. In vitro activities of a new lipopeptide antifungal agent, FK463, against a variety of clinically important fungi
3. Efficacy of FK463, a new lipopeptide antifungal agent, in mouse models of disseminated candidiasis and aspergillosis
4. Efficacy of FK463, a new lipopeptide antifungal agent, in mouse models of pulmonary aspergillosis
5. Characterization and cilofungin inhibition of solubilized Aspergillus fumigatus (1,3)-β-D-glucan synthase
6. Cilofungin (LY121019) inhibits Candida albicans (1,3)-β-D-glucan synthase activity
7. W-1 solubilization and kinetics of inhibition by cilofungin of Candida albicans (1,3)-β-D-glucan synthase
8. Morphological effects of lipopeptides against Aspergillus fumigatus correlate with activities against (1,3)-β-D-glucan synthase
9. Identification of the FKS1 gene of Candida albicans as the essential target of 1,3-β-D-glucan synthase inhibitors
10. Cloning of the Candida albicans homolog of Saccharomyces cerevisiae GSC1/FKS1 and its involvement in β-1,3-glucan synthesis
11. The Saccharomyces cerevisiae FKS1(ETG1) gene encodes an integral membrane protein which is a subunit of 1,3-β-D-glucan synthase
12. Cloning of the RHO1 gene from Candida albicans and its regulation of β-1,3-glucan synthesis
13. In vitro activity of 1,3-β-D-glucan synthase requires the GTP-binding protein Rho1