Induction of DNA damage by oxidised amino acids and proteins

Biogerontology

Volumn 3, Issue 1-2, 2002, Pages 95-102

  Luxford, Catherine ^a   Dean, Roger T ^a   Davies, Michael J ^a  

^a HEART RESEARCH INSTITUTE   (Australia)

Author keywords

DNA damage; DNA protein cross links; Hydroperoxides; Oxidation; Protein damage; Radicals; Strand breaks

Indexed keywords

AMINO ACID; CARBON; DNA; HYDROPEROXIDE; METAL ION; OXYGEN; PEPTIDE; PROTEIN; RADICAL;

ARTICLE; CATALYST; CONTROLLED STUDY; DECOMPOSITION; DNA DAMAGE; DNA PROTEIN COMPLEX; DNA STRAND BREAKAGE; DOSE RESPONSE; HEAT; LIGHT; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; PROTEIN CROSS LINKING;

AMINO ACIDS; ANIMALS; CATTLE; DNA DAMAGE; ELECTROPHORESIS, AGAR GEL; HYDROGEN PEROXIDE; OXIDATION-REDUCTION; PROTEINS;

EID: 0036209249     PISSN: 13895729     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1015228001561     Document Type: Article

References (30)

1. Molecular Biology of Free Radicals in Human Diseases
2. Fluorometric assay of proteins in the nanogram range
3. Protein and peptide alkoxyl radicals can give rise to C-terminal decarboxylation and backbone cleavage
4. Radical Mediated Protein Oxidation: From Chemistry to Medicine
5. Protein hydroperoxides can give rise to reactive free radicals
6. Stable markers of oxidant damage to proteins and their application in the study of human disease
7. Biochemistry and pathology of radical-mediated protein oxidation
8. The use of capillary gas-chromatography mass-spectroscopy for identification of radiation-induced base damage and DNA-base amino-acid cross-links
9. Structure and mechanism of hydroxyl radical-induced formation of a DNA-protein cross-link involving thymine and lysine in nucleohistone
10. Structure of a hydroxyl radical induced DNA-protein cross-link involving thymine and tyrosine in nucleohistone
11. Hydroxyl radical induced cross-linking between phenylalanine and 2-deoxyribose
12. Biological fate of amino acid, peptide and protein hydroperoxides
13. Hydroxyl radical induced cross-linking of cytosine and tyrosine in nucleohistone
14. Hydroperoxide assay with the ferric-xylenol orange complex
15. Protein hydroperoxides as new reactive oxygen species
16. Formation of peroxides in amino acids and proteins exposed to oxygen free radicals
17. Crosslinking of DNA and proteins induced by protein hydroperoxides
18. Inactivation of glutathione reductase by protein and amino acid peroxides
19. I) and monoperoxyphthalic acid and its anion
20. Direct detection of radical generation in rat liver nuclei on treatment with tumour-promoting hydroperoxides and related compounds
21. Iodometric determination of hydroperoxides in lipids and proteins
22. Generation of putative intrastrand cross-links and strand breaks in DNA by transition metal ion-mediated oxygen radical attack
23. Radicals derived from histone hydroperoxides damage nucleobases in RNA and DNA
24. Histone H1- and other protein- and amino acid-hydroperoxides can give rise to free radicals which oxidise DNA
25. Predominance of core histones in formation of DNA-protein crosslinks in γ-irradiated chromatin
26. Chemical nature of DNA-protein cross-links produced in mammalian chromatin by hydrogen peroxide in the presence of iron and copper ions
27. 2-treated cultured cells
28. Long-lived reactive species on free-radical-damaged proteins
29. Induction of DNA damage in γ-irradiated nuclei stripped of nuclear protein classes: Differential modulation of double-strand break and DNA-protein crosslink formation