The virally encoded fungal toxin KP4 specifically blocks L-type voltage-gated calcium channels

Molecular Pharmacology

Volumn 61, Issue 4, 2002, Pages 936-944

  Gage, Matthew J ^a   Rane, Stanley G ^a   Hockerman, Gregory H ^b   Smith, Thomas J ^c  

^a DONALD DANFORTH PLANT SCIENCE CENTER   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

^c PURDUE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCISEPTINE; CALCIUM CHANNEL; CALCIUM CHANNEL L TYPE; CHARYBDOTOXIN; MYCOTOXIN; PROTEIN KP 4; TETRODOTOXIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING COMPETITION; CALCIUM TRANSPORT; CHEMICAL MODIFICATION; CONTROLLED STUDY; CYTOTOXICITY; DEPOLARIZATION; ELECTROPHYSIOLOGY; EXTRACELLULAR CALCIUM; HUMAN; HUMAN CELL; MAMMAL CELL; MEMBRANE POTENTIAL; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; PROTEIN STRUCTURE; RECEPTOR BLOCKING; SEQUENCE HOMOLOGY; USTILAGO MAYDIS; VOLTAGE CLAMP;

ANIMALS; CALCIUM; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS, L-TYPE; CELLS, CULTURED; ELECTROPHYSIOLOGY; LYSINE; MYCOTOXINS; PC12 CELLS; RATS; VIRAL PROTEINS;

EID: 0036207873     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.61.4.936     Document Type: Article

References (54)

1. Classes of calcium channels in vertebrate cells
2. Effects of yeast killer factor on sensitive cells
3. 2+ channels by benzothiazepines and phenylalkylamines: Class-specific pharmacology and underlying molecular determinants
4. + channels
5. Structure and function of voltage-gated ion channels
6. 2+ channels and their role in neurotransmitter release
7. Calcium signaling
8. High affinity block of myocardial L-type calcium channels by the spider toxin omega-AGA-toxin IIIA: Advantages over 1,4-dihydropyridines
9. 2+ transport in Sacchromyces cerevisiae
10. α-Scorpion neurotoxin derivatives suitable as potential markers of sodium channels
11. Calcium in Sacchromyces cerevisiae
12. Calciseptine, a peptide isolated from black mamba venom, is a specific blocker of the L-type calcium channel
13. Sequence and expression of mRNAs encoding the α1 and α2 subunits of a DHP-sensitive calcium channel
14. A novel hydrophobic ω-conotoxin blocks molluscan diydropyridine-sensitive calcium channels
15. The Sacchromyces cerevisiae CCHI gene is involved in calcium influx and mating
16. Kinetic and pharmacological properties distinguishing three types of calcium currents in chick sensory neurons
17. KP4 fungal toxin inhibits growth in Ustilago maydis by blocking calcium uptake
18. Purification and molecular properties of the toxin coded by Ustilago maydis virus P4
19. Ustilago maydis virus P4 killer toxin: Characterization, partial amino terminus sequence, and evidence for glycosylation
20. 2+ channel inhibitor
21. The characterization and crystallization of a virally encoded Ustilago Maydis KP4 toxin
22. 2+-sensitive dye Indo-1
23. Nature of a factor causing interstrain lethality in Ustilago maydis
24. Molecular mechanism of use-dependent calcium channel block by phenylalkylamines: Role of inactivation
25. 2+ influx and mating
26. 2+ in Saccharomyces cerevisiae
27. 2+], rise in maintaining viability of yeast cells late in the mating pheromone response pathway
28. Roles of calcium ions in hyphal growth
29. Distinct effects of mutations in transmembrane segment VS6 on block of L-type calcium channels by structurally similar phenylalkylamines
30. Toxin γ of the scorpion Tityus serrulatus modifies both activation and inactivation of sodium permeability of nerve membrane
31. Molecular identification of a eukaryotic stretch-activated nonselective cation channel
32. 2+ channel binding site of calciseptine and FS2
33. Nuclease activity associated with the Ustilago maydis virus induced killer proteins
34. Calcium channels in excitable cells: Divergent genotypic and phenotypic expression of alpha 1-subunits
35. 2+ in yeast
36. Mutant potassium channels with altered binding of charybdotoxin, a pore-blocking peptide inhibitor
37. 2+ stores in neuronal and neuroendocrine cells
38. A region in IVS5 of the human cardiac L-type calcium channel is required for the use-dependent block by phenylalkylamines and benzothiazepines
39. Calcium channel diversity and neurotransmitter release: The ω-conotoxins and ω-agatoxins
40. Structure and heterologous expression of Ustilago maydis viral toxin KP4
41. Cloning and tissuespecific expression of the brain calcium channel beta-subunit
42. Compatibility reactions on solid medium and interstrain inhibition in Ustilago maydis
43. Structure-function relationships in scorpion neurotoxins: Identification of the superreactive lysine in toxin I of Androctonus australis Hector
44. Distinct calcium channels are generated by alternative splicing and are differentially expressed in the mammalian CNS
45. Structure and functional expression of a member of the low voltage-activated calcium channel family
46. A fluorometric assay of the degree of modification of protein primary amines with polyethylene glycol
47. + channels
48. Effects of calciseptine on unitary barium channel currents in guinea-pig portal vein
49. Mapping the site of block by tetrodotoxin and saxitoxin of sodium channel II
50. Calcium channels, stores and oscillations
51. 2+ channels in rat phaeochromocytoma cell lines
52. Mitogen-activated protein kinase activation is insufficient for growth factor receptor-mediated PC12 cell differentiation
53. 2+ channels
54. Killer yeasts