The selective triggering of CD40 on keratinocytes in vivo enhances cell-mediated immunity

European Journal of Immunology

Volumn 32, Issue 3, 2002, Pages 895-902

  Fuller, Bruce W ^a   Nishimura, Toshihide ^b   Noelle, Randolph J ^a  

^a DARTMOUTH MEDICAL SCHOOL   (United States)

^b OSAKA UNIVERSITY   (Japan)

Author keywords

Cell trafficking; Cellular activation; Costimulation; Inflammation; Skin

Indexed keywords

CD40 ANTIGEN; KERATIN; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANTIGEN EXPRESSION; ANTIGEN FUNCTION; ARTICLE; CELL MIGRATION; CELLULAR IMMUNITY; CONTROLLED STUDY; DENDRITIC CELL; HEMATOPOIETIC CELL; HYPERSENSITIVITY; IMMUNE RESPONSE; IMMUNOREGULATION; IN VIVO STUDY; KERATINOCYTE; LYMPH NODE; LYMPHATIC DRAINAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; SENSITIZATION; T LYMPHOCYTE;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS, CD40; CHEMOTAXIS; DENDRITIC CELLS; DERMATITIS, ALLERGIC CONTACT; EAR, EXTERNAL; EPIDERMIS; FEMALE; HUMANS; IMMUNITY, CELLULAR; KERATINOCYTES; KERATINS; LYMPH NODES; MICE; MICE, TRANSGENIC; ORGAN SPECIFICITY; OXAZOLONE; PROMOTER REGIONS (GENETICS); RECOMBINANT FUSION PROTEINS; RNA, MESSENGER; T-LYMPHOCYTES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0036206259     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/1521-4141(200203)32:3<895::AID-IMMU895>3.0.CO;2-A     Document Type: Article

References (19)

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2. The CD40/CD154 receptor/ligand dyad
3. CD40 is functionally expressed on human keratinocytes
4. Human epidermal keratinocytes are induced to secrete interleukin-6 and co-stimulate T lymphocyte proliferation by a CD40-dependent mechanism
5. CD40 ligation of human keratinocytes inhibits their proliferation and induces their differentiation
6. Effects of CD40 ligation on human keratinocytes accessory function
7. CD40 ligation alters the cell cycle of differentiating keratinocytes
8. Localization of keratin mRNA in human tracheobronchial epithelium and bronchogenic carcinomas by in situ hybridization
9. Unopposed positive selection and autoreactivity in mice expressing class II MHC only on thymic cortex
10. Depressed Langerhans cell migration and reduced contact hypersensitivity response in mice lacking TNF receptor p75
11. CD40-CD40 ligand interactions in vivo regulate migration of antigen-bearing dendritic cells from the skin to draining lymph nodes
12. Epidermal expression of intercellular adhesion molecule 1 is not a primary inducer of cutaneous inflammation in transgenic mice
13. Characterization of the altered cutaneous reactivity of transgenic mice whose keratinocytes overexpress B7-1
14. Keratinocyte expression of B7-1 in transgenic mice amplifies the primary immune response to cutaneous antigens
15. Exaggerated and persistent cutaneous delayed-type hypersensitivity in transgenic mice whose epidermal keratinocytes constitutively express B7-1 antigen
16. Immune regulation by CD40 and its ligand gp39
17. The human B lymphocyte and carcinoma antigen, CDw40, is a phosphoprotein involved in growth signal transduction
18. Ox40-ligand has a critical costimulatory role in dendritic cell: T cell interactions
19. Mechanisms of immunotherapeutic intervention by anti-CD40L (CD154) antibody in an animal model of multiple sclerosis