The antimicrotubule drug estramustine but not irradiation induces apoptosis in malignant glioma involving AKT and caspase pathways

Journal of Neuro-Oncology

Volumn 56, Issue 2, 2002, Pages 143-148

  Vallbo, Christina ^a   Bergenheim, Tommy ^a   Hedman, Håkan ^a   Henriksson, Roger ^a  

^a UMEÅ UNIVERSITY   (Sweden)

Author keywords

Apoptosis; Estramustine; Glioma; Irradiation; Signal transduction

Indexed keywords

CASPASE 3; CASPASE 3 INHIBITOR; ESTRAMUSTINE; ESTRAMUSTINE PHOSPHATE; JANUS KINASE; LIPOCORTIN 5; MITOGEN ACTIVATED PROTEIN KINASE; N ACETYLASPARTYLGLUTAMYLVALYLASPARTYLALDEHYDE; PROTEIN KINASE B; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOPHYSIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CANCER ADJUVANT THERAPY; CELL LINE; CONTROLLED STUDY; ENZYME BLOOD LEVEL; FEMALE; GENETIC ANALYSIS; GLIOMA; GLIOMA CELL; IN VITRO STUDY; IN VIVO STUDY; IRRADIATION; MALE; MALIGNANT NEOPLASTIC DISEASE; NICK END LABELING; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RADIATION RESPONSE; RAT; SIGNAL TRANSDUCTION; TUMOR MODEL; WESTERN BLOTTING;

ANIMALS; ANTINEOPLASTIC AGENTS, ALKYLATING; APOPTOSIS; BRAIN NEOPLASMS; CASPASES; CYSTEINE PROTEINASE INHIBITORS; ENZYME ACTIVATION; ESTRAMUSTINE; GLIOMA; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MAP KINASE KINASE 4; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MITOGEN-ACTIVATED PROTEIN KINASES; OLIGOPEPTIDES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RATS; SIGNAL TRANSDUCTION; TUMOR CELLS, CULTURED;

EID: 0036204825     PISSN: 0167594X     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1014562503097     Document Type: Article

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