Determinants of 4-aminopyridine sensitivity in a human brain Kv1.4 K+ channel: Phenylalanine substitutions in leucine heptad repeat region stabilize channel closed state

Molecular Pharmacology

Volumn 61, Issue 4, 2002, Pages 913-920

  Judge, Susan I V ^a   Yeh, Jay Z ^a   Goolsby, James E ^b   Monteiro, Mervyn J ^c   Bever Jr , Christopher T ^d  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF MARYLAND   (United States)

^d NORTHWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOPYRIDINE; POTASSIUM CHANNEL;

AMINO ACID SUBSTITUTION; ARTICLE; BINDING AFFINITY; BINDING SITE; CHANNEL GATING; CONTROLLED STUDY; DEPOLARIZATION; DRUG PROTEIN BINDING; ELECTRIC POTENTIAL; GENETIC TRANSFECTION; HELA CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; MOLECULAR DYNAMICS; MOLECULAR MODEL; PATCH CLAMP; POINT MUTATION; POTASSIUM CURRENT; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN STABILITY;

4-AMINOPYRIDINE; AMINO ACID SUBSTITUTION; BRAIN; CELLS, CULTURED; CLONING, MOLECULAR; HUMANS; KV1.4 POTASSIUM CHANNEL; LEUCINE; MUTAGENESIS; PHENYLALANINE; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS; POTASSIUM CHANNELS, VOLTAGE-GATED; REPETITIVE SEQUENCES, AMINO ACID;

EID: 0036204199     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.61.4.913     Document Type: Article

References (20)

1. + channel
2. A model for 4-aminopyridine action on K channels: Similarities to tetraethylammonium ion action
3. + channels in open, closed, and inactivated conformations
4. + channel can be trapped in the open state by an intersubunit metal bridge
5. Increased apoptosis arising from increased expression of the Alzheimer's disease-associated presenilin-2 mutation
6. Inactivation gating and 4-AP sensitivity in human brain Kv1.4 potassium channel
7. Gating-dependent mechanism of 4-aminopyridine block of two related potassium channels
8. + pores
9. + channel
10. Resolving the gating charge movement associated with late transitions in K channel activation
11. + channels
12. Leucine-zipper motif update
13. + channels
14. + channels
15. An essential binding surface for ShK toxin interaction with rat brain potassium channels
16. Structural conservation of the pores of calcium-activated and voltage-gated potassium channels determined by a sea anemone toxin
17. + channels
18. + channels
19. The gating mechanism of the large mechanosensitive channel MscL
20. Structural models of the MscL gating mechanism