Preferential localization of the Epstein-Barr virus (EBV) oncoprotein LMP-1 to nuclei in human T cells: Implications for its role in the development of EBV genome-positive T-cell lymphomas

Journal of Virology

Volumn 76, Issue 8, 2002, Pages 4080-4086

  Xu, Jingwu ^a   Ahmad, Ali ^a   Menezes, José ^a  

^a UNIVERSITY OF MONTREAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

LATENT MEMBRANE PROTEIN 1; ONCOPROTEIN;

ARTICLE; B LYMPHOCYTE; CELL CYCLE G2 PHASE; CELL IMMORTALIZATION; CELL NUCLEUS; COMPUTER ANALYSIS; CONTROLLED STUDY; EPSTEIN BARR VIRUS; HUMAN; HUMAN CELL; LYMPHOCYTE TRANSFORMATION; MITOSIS; NONHUMAN; NUCLEAR LOCALIZATION SIGNAL; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; T CELL LYMPHOMA; T LYMPHOCYTE; VIRUS GENOME;

B-LYMPHOCYTES; CELL LINE; CELL NUCLEUS; GENOME, VIRAL; HERPESVIRUS 4, HUMAN; HUMANS; LYMPHOMA, T-CELL; T-LYMPHOCYTES; TRANSFECTION; VIRAL MATRIX PROTEINS;

EID: 0036200425     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.76.8.4080-4086.2002     Document Type: Article

References (54)

1. Stable expression of the transfected HIV-1 env gene in a human B cell line: Characterization of gp120-expressing clones and immunobiological studies
2. Latent membrane protein-1 induces cyclin D2 expression, pRb hyperphosphorylation, and loss of TGF-beta 1-mediated growth inhibition in EBV-positive B cells
3. EBV persistence in memory B cells in vivo
4. Epstein-Barr virus latent infection membrane protein increases vimentin expression in human B-cell lines
5. Severe chronic EBV infection associated with specific EBV immunodeficiency and an EBNA+ T-cell lymphoma containing linear
6. Epstein-Barr virus (EBV) gene expression in EBV-positive peripheral T-cell lymphomas
7. Epstein-Barr virus latent membrane protein inhibits human epithelial cell differentiation
8. Expression, molecular association, and functions of C3 complement receptors CR1 (CD35) and CR2 (CD21) on the human T cell line HPB-ALL
9. Epstein-Barr virus: LMP1 masquerades as an active receptor
10. Epstein-Barr virus-encoded latent membrane protein 1 activates the JNK pathway through its extreme C terminus via a mechanism involving TRADD and TRAF2
11. Early detection of the lytic LMP-1 protein in EBV-infected B-cells suggests its presence in the virion
12. Cytostatic effect of Epstein-Barr virus latent membrane protein-1 analyzed using tetracycline-regulated expression in B cell lines
13. Epstein-Barr virus latent membrane protein 1 blocks p53-mediated apoptosis through the induction of the A20 gene
14. Latent membrane protein 1 of Epstein-Barr virus interacts with JAK3 and activates STAT proteins
15. The transforming domain alone of the latent membrane protein of Epstein-Barr virus is toxic to cells when expressed at high levels
16. Epstein-Barr virus in nasal T-cell lymphomas in patients with lethal midline granuloma
17. A fusion of the EBV latent membrane protein-1 (LMP1) transmembrane domains to the CD40 cytoplasmic domain is similar to LMP1 in constitutive activation of epidermal growth factor receptor expression, nuclear factor-kappa B, and stress-activated protein kinase
18. Two related but differentially expressed potential membrane proteins encoded by the EcoRI Dhet region of Epstein-Barr virus B95-8
19. T-cell lymphomas containing Epstein-Barr viral DNA in patients with chronic Epstein-Barr virus infections
20. The human immunodeficiency virus type 1 Rev protein shuttles between the cytoplasm and nuclear compartments
21. Cytoskeleton association and virion incorporation of the human immunodeficiency virus type 1 Vif protein
22. Expression of Epstein-Barr virus latent membrane protein 1 protects Jurkat T cells from apoptosis induced by serum deprivation
23. Epstein-Barr virus latent membrane protein 1 is essential for B-lymphocyte growth transformation
24. Epstein-Barr virus in angioimmunoblastic T-cell lymphomas
25. Immune regulation in Epstein-Barr virus-associated diseases
26. Epstein-Barr virus and its replication
27. Expression of the Epstein-Barr virus latent membrane protein 1 induces B cell lymphoma in transgenic mice
28. Epstein-Barr virus latent membrane protein: Induction of B-cell activation antigens and membrane patch formation does not require vimentin
29. An Epstein-Barr virus transforming protein associates with vimentin in lymphocytes
30. Posttranslational processing of the Epstein-Barr virus-encoded p63/LMP protein
31. Epstein-Barr virus genome in thymoma and thymic lymphoid hyperplasia
32. Establishment and characterization of an Epstein-Barr virus (EBV) negative lymphoblastoid B cell line from an exceptional, EBV-genome negative African Burkitts lymphoma
33. Epstein-Barr virus LMP1 induction of the epidermal growth factor receptor is mediated through a TRAF signaling pathway distinct from NF-KB activation
34. All three domains of the Epstein-Barr virus-encoded latent membrane protein LMP-1 are required for transformation of rat-1 fibroblasts
35. The Epstein-Barr virus transforming protein LMP1 engages signaling proteins for the tumor necrosis factor receptor family
36. Nucleocytoplasmic transport: Signals, mechanisms and regulation
37. Activation of human thymocytes after infection by EBV
38. Model of Epstein-Barr virus infection of human thymocytes: Expression of viral genome and impact on cellular receptor expression in the T-lymphoblastic cell line, HPB-ALL
39. Transport routes through the nuclear pore complex
40. Transient expression of the Epstein-Barr virus LMP1 gene in B-cell chronic lymphocytic leukemia cells, T cells, and hematopoietic cell lines: Cell-type-independent-induction of CD23, CD21, and ICAM-1
41. Viral protein R regulates nuclear import of the HIV-1 pre-integration complex
42. Epstein-Barr virus
43. Characterization of the EBV/C3d receptor on the human Jurkat T cell line: Evidence for a novel transcript
44. Lack of the expression of EBNA-2 and LMP-1 in T-cell neoplasms possessing Epstein-Barr virus
45. Detection of Epstein-Barr viral DNA in aggressive CD8+ T cell leukaemic cells
46. Epstein-Barr virus in adult T-cell leukemia/lymphoma
47. Expression of CR2/EBV receptors on human thymocytes detected by monoclonal antibodies
48. Mimicry of CD40 signals by Epstein-Barr virus LMP1 in B lymphocyte responses
49. The truncated form of the Epstein-Barr virus latent-infection membrane protein expressed in virus replication does not transform rodent fibroblasts
50. Epstein-Barr virus latent membrane protein (LMPI) and nuclear proteins 2 and 3C are effectors of phenotypic changes in B lymphocytes: EBNA-2 and LMP1 cooperatively induce CD23
51. Expression of the Epstein Barr virus transforming protein LMP1 causes a rapid and transient stimulation of the Bcl-2 homologue Mcl-1 levels in B-cell lines
52. Infection of human thymocytes by Epstein-Barr virus
53. RanBP3 contains an unusual nuclear localization signal that is imported preferentially by importin-alpha3
54. Analysis and significance of anti-latent membrane protein-1 antibodies in the sera of patients with EBV-associated diseases