Expression of the Epstein Barr virus transforming protein LMP1 causes a rapid and transient stimulation of the Bcl-2 homologue Mcl-1 levels in B- cell lines

Cancer Research

Volumn 56, Issue 20, 1996, Pages 4610-4613

  Wang, Shu ^a   Rowe, Martin ^b   Lundgren, Erik ^a  

^a UMEÅ UNIVERSITY   (Sweden)

^b UNIVERSITY DEPARTMENT OF MEDICINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; B CELL LEUKEMIA; B LYMPHOCYTE; EPSTEIN BARR VIRUS; HUMAN; HUMAN CELL; LEUKEMOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; VIRUS CARCINOGENESIS;

APOPTOSIS; B-LYMPHOCYTES; CADMIUM; CELL LINE; HUMANS; NEOPLASM PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; TIME FACTORS; VIRAL MATRIX PROTEINS;

EID: 0029795731     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (19)

1. Wang, D., Liebowitz, D., and Kieff, E An EBV membrane protein expressed in immortalized lymphocytes transforms established rodent cells. Cell, 43, 831-840, 1985.
2. Henderson, S., Rowe, M , Gregory, C., Croom-Carter, D., Wang, F , Longnecher, R., Kieff, E., and Rickinson, A Induction of bcl-2 expression by Epstein-Barr virus latent membrane protein 1 protects infected B cells from programmed cell death. Cell, 65: 1107-1115, 1991.
3. Okan, I., Wang, Y , Chen, F , Hu, L-F., Imreh, S., Klein, G., and Wiman, K. G. The EBV-encoded LMP1 protein inhibits p53-triggered apoptosis but not growth arrest. Oncogene, 11: 1027-1031, 1995.
4. Rowe, M., Peng-Pilon, M., Huen, D. S , Hardy, R, Croom-Carter, D., Lundgren, E., and Rickinson, A. B. Upregulation of bcl-2 by the Epstein-Barr virus latent membrane protein LMP1: a B-cell specific response that is delayed relative to NF-κB activation and to induction of cell surface markers J. Virol., 68: 5602-5612, 1994.
5. White, E. Life, death, and the pursuit of apoptosis. Gene Dev., 10, 1-15, 1996.
6. Bodrug, S. E., Aime-Sempe, C., Sato, T., Krajewski, S., Hanada, M., and Reed, J. C. Biochemical and functional comparisons of Mcl-1 and Bcl-2 proteins: evidence for a novel mechanism of regulating Bcl-2 family protein function. Death & Differ., 2: 173-182, 1996.
7. Reynolds, J E , Yang, T , Qian, L., Jenkinson, D., Zhou, P , Eastman, A., and Craig, R. W. Mcl-1, a member of the Bcl-2 family, delays apoptosis induced by c-Myc overexpression in Chinese hamster ovary cells Cancer Res., 54: 6348-6352, 1994.
8. Kozopas, K. M , Yang, T., Buchan, H. L , Zhou, P , and Craig, R W. MCL1, a gene expressed in programmed myeloid cell differentiation, has sequence similarity to BCL2. Proc Natl. Acad. Sci. USA, 90: 3516-3520, 1993.
9. Yang, T., Kozopas, K. M , and Craig, R. W The intracellular distribution and pattern of expression of Mcl-1 overlap with, but are not identical to, those of Bcl-2. J. Cell Biol. 128: 1173-1184, 1995.
10. Yang, T., Buchan, H. L., Townsend, K J , and Craig, R W Mcl-1, a member of the Bcl-2 family, is induced rapidly in response to signals for cell differentiation or death, but not to signals for cell proliferation. J. Cell. Physiol., 166: 523-536, 1996
11. Cuomo, L , Trivedi, P., Wang, F., Winberg, G., Klein G , and Masucci, M G. Expression of the Epstein-Barr virus (EBV)-encoded membrane antigen LMP1 increases the stimulatory capacity of EBV-negative B lymphoma lines in allogeneic mixed lymphocyte cultures. Eur. J. Immunol., 20: 2293-2299, 1990.
12. Wang, F, Gregory, C., Sample, C., Rowe, M., Liebowitz, D , Murray R., Rickinson, A., and Kieff, E. Epstein-Barr virus latent membrane protein (LMP1) and nuclear proteins 2 and 3C are effectors of phenotypic changes in B lymphocytes: EBNA-2 and LMP1 cooperatively induce CD23. J. Virol., 64: 2309-2318, 1990
13. Peng, M., and Lundgren, E. Transient expression of the EBV LMP1 gene in B-cell chronic lymphocytic leukemia cells, T cells and hemotopoietic cell lines, cell-type-independent-induction of CD23, CD21 and ICAM-I Leukemia (Baltimore), 7: 104-112, 1993.
14. Krishan, A. Rapid flow cytofluorometric analysis of mammalian cell cycle by propidium iodide staining J. Cell Biol., 66: 188-193, 1975.
15. Lomo, J , Blomhoff, H. K., Beiske, K., Stokke, T., and Smeland, E. B. TGFβ1 and cAMP promote apoptosis in resting human B lymphocytes J Immunol., 154: 1634-1643, 1995.
16. Lomo, J , Smeland, E. B., Krajewski, S., Reed, J. C., and Blomhoff, H. K. Expression of the Bcl-2 homologue Mcl-1 correlates with survival of peripheral blood B lymphocytes Cancer Res., 56 40-43, 1996.
17. Ohta, K., Iwai, K., Kasahara, Y., Taniguchi, N., Krajewski, S., Reed, J C., and Miyawaki, T. Immunoblot analysis of cellular expression of Bcl-2 family proteins, Bcl-2, Bax, Bcl-X and Mcl-1, in human peripheral blood and lymphoid tissues. Int Immunol. 7: 1817-1825, 1995
18. Krajewski, S., Bodrug, S. E., Gascoyne, R., Berean, K , Krajewska, M., and Reed, J C Immunohistochemical analysis of Mcl-1 and Bcl-2 proteins in normal and neoplastic lymph nodes. Am. J Pathol., 145: 515-525, 1994
19. Krajewski, S., Bodrug, S. E., Krajewska, M , Aime-Sempe, C , Gascoyne, R., Berean, K., and Reed, J C. Immunohistochemical analysis of Mcl-1 protein in human tissues: differential regulation of Mcl-1 and Bcl-2 protein production suggests a unique role for Mcl-1 in control of programmed cell death in vivo. Am J Pathol , 146: 1309-1319, 1995