Dendritic cells cultured in anti-cd40 antibody-immobilized plates elicit a highly efficient peptide-specific t-cell response

Journal of Immunotherapy

Volumn 25, Issue 2, 2002, Pages 176-184

  Osada, Takuya ^a   Nagawa, Hirokazu ^a   Takahashi, Tsuyoshi ^a   Tsuno, Nelson H ^a   Kitayama, Joji ^a   Shibata, Yoichi ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

CD40; CD83; Cytotoxic T lymphocyte; Dendritic cell; Interleukin 12

Indexed keywords

CARCINOEMBRYONIC ANTIGEN; CD4 ANTIGEN; CD40 ANTIGEN; CD40 MONOCLONAL ANTIBODY; CD8 ANTIGEN; CD83 ANTIGEN; EPITOPE; GAMMA INTERFERON; HLA A2 ANTIGEN; HLA A24 ANTIGEN; INTERLEUKIN 12; MONOCLONAL ANTIBODY; UNCLASSIFIED DRUG;

ANTIGEN EXPRESSION; ANTIGEN PRESENTATION; ARTICLE; CANCER CELL CULTURE; CELL MATURATION; CELLULAR IMMUNITY; CHEMICAL COMPOSITION; CONTROLLED STUDY; CULTURE MEDIUM; CYTOKINE RELEASE; CYTOTOXIC T LYMPHOCYTE; DENDRITIC CELL; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMOBILIZED CELL; IN VITRO STUDY; LEUKOCYTE CULTURE; MAJOR HISTOCOMPATIBILITY COMPLEX RESTRICTION; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION;

ANTIBODIES, MONOCLONAL; ANTIGEN PRESENTATION; ANTIGENS, CD; ANTIGENS, CD40; CELL DIFFERENTIATION; COCULTURE TECHNIQUES; CYTOKINES; DENDRITIC CELLS; HUMANS; IMMUNOGLOBULINS; INTERFERON-GAMMA, RECOMBINANT; MEMBRANE GLYCOPROTEINS; PEPTIDES; PHENOTYPE; T-LYMPHOCYTES; T-LYMPHOCYTES, CYTOTOXIC;

EID: 0036200241     PISSN: 10538550     EISSN: None     Source Type: Journal    
DOI: 10.1097/00002371-200203000-00005     Document Type: Article

References (40)

1. Dendritic cells: Antigen presentation, accessory function and clinical relevance
2. Recent advances in the study of dendritic cells and follicular dendritic cells
3. Antigen-bearing Langerhans cells in skin draining lymph nodes: Phenotype and kinetics of migration
4. The antigen-presenting activities of Ia+ dendritic cells shift dramatically from lung to lymph node after an airway challenge with soluble antigen
5. Localization of antigen on lymph node dendritic cells after exposure to the contact sensitizer fluorescein isothiocyanate. Functional and morphological studies
6. Dendritic cells and macrophages can mature independently from a human bone marrow-derived, post-colony-forming unit intermediate
7. Generation of dendritic cells in vitro from peripheral blood mononuclear cells with granulocyte-macrophage-colony stimulating factor, interleukin-4, and tumor necrosis factor-α for use in cancer immunotherapy
8. Origin, maturation and antigen presenting function of dendritic cells
9. Dendritic cells and the control of immunity
10. Immature dendritic cells generated with low doses of GM-CSF in the absence of 1L-4 are maturation resistant and prolong allograft survival in vivo
11. The induction of tolerance by dendritic cells that have captured apoptotic cells
12. CD40 and CD154 in cell-mediated immunity
13. CD40 and its ligand, an essential ligand-receptor pair for thymus-dependent B-cell activation
14. Functions of CD40 on B cells, dendritic cells and other cells
15. A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer cell
16. Help for cytotoxic-T-cell responses is mediated by CD40 signaling
17. T-cell help for cytotoxic T lymphocytes is mediated by CD40-CD40L interactions
18. CD40 activation in vivo overcomes peptide-induced peripheral cytotoxic T-lymphocyte tolerance and augments anti-tumor vaccine efficacy
19. CD40 ligand induces an antileukemia immune response in vivo
20. Autologous tumor infiltrating T cells cytotoxic for follicular lymphoma cells can be expanded in vitro
21. CD40-activated human B cells: An alternative source of highly efficient antigen presenting cells to generate autologous antigen-specific T cells for adoptive immunotherapy
22. Gene transfer of CD40-ligand induces autologous immune recognition of chronic lymphocytic leukemia B cells
23. Ex vivo generation of human anti-pre-B leukemia-specific autologous cytolytic T cells
24. Exogeneous CD40 ligand induces a pulmonary inflammation response
25. Dendritic cells modified to express CD40 ligand elicit therapeutic immunity against preexisting murine tumors
26. High-level IL-12 production by human dendritic cells requires two signals
27. Final maturation of dendritic cells is associated with impaired responsiveness to IFN-γ and to bacterial IL-12 inducers: Decreased ability of mature dendritic cells to produce IL-12 during the interaction with Th cells
28. Human dendritic cells require exogenous interleukin-12-inducing factors to direct the development of naive T-helper cells toward the Th1 phenotype
29. Optimization of the sequence of antigen loading and CD40-ligand-induced maturation of dendritic cells
30. A subset of human monocyte-derived dendritic cells expressed high levels of interleukin-12 in response to combined CD40 ligand and interferon-γ treatment
31. Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha
32. CD14+ blood morlocytes can differentiate into functionally mature CD83+ dendritic cells
33. Proliferating dendritic cell progenitors in human blood
34. Specific expression of surface interferon-γ on interferon-γ producing T cells from mouse and man
35. Identification of an enhancer agonist cytotoxic T lymphocyte peptide from human carcinoembryonic antigen
36. Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation
37. IL-4 and CD40 ligation affect differentiation, maturation, and function of human CD34+ cell-derived CD1a+CD14- and CD1a-CD14+ dendritic cell precursors in vitro
38. IL-12: A key cytokine in immune regulation
39. High level of IL-12 production by murine dendritic cells: Upregulation via MHC class II and CD40 molecules and downregulation by IL-4 and IL-10
40. Interleukin-18 synthesis and secretion by dendritic cells are modulated by interaction with antigen-specific T cells