Novel approaches to prodrugs of anticancer diaminodichloroplatinum(II) complexes activated by stereoselective enzymatic ester hydrolysis

Journal of Inorganic Biochemistry

Volumn 70, Issue 1, 1998, Pages 25-32

  Kageyama, Yuichi ^a,b   Yamazaki, Yoshimitsu ^a   Okuno, Hiroaki ^a,b  

^a NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY AIST   (Japan)

^b UNIVERSITY OF TSUKUBA   (Japan)

Author keywords

Anticancer; Hydrophobicity; Platinum complex; Prodrug; Stereoselective activation

Indexed keywords

ANTINEOPLASTIC AGENT; CISPLATIN; PRODRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CHIRALITY; CYTOTOXICITY; ENZYME ACTIVITY; HOMOGENATE; HYDROLYSIS; HYDROPHOBICITY; MEMBRANE PERMEABILITY; STEREOCHEMISTRY;

EID: 0031850249     PISSN: 01620134     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0162-0134(98)00009-9     Document Type: Article

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