Activation of Shiga toxin type 2d (Stx2d) by elastase involves cleavage of the C-terminal two amino acids of the A2 peptide in the context of the appropriate B pentamer

Molecular Microbiology

Volumn 43, Issue 1, 2002, Pages 207-215

  Melton Celsa, Angela R ^a   Kokai Kun, John F ^a,b   O'Brien, Alison D ^a  

^a Uniformed Services University of the Health Sciences and the Walter Reed National Military Medical Center   (United States)

^b Biosynexus Incorporated   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ELASTASE; PROTEIN SUBUNIT; SHIGA TOXIN TYPE 2D; STREPTOMYCIN; UNCLASSIFIED DRUG; VEROTOXIN 1; VEROTOXIN 2;

AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL MODEL; ARTICLE; BACTERIAL INFECTION; BACTERIAL VIRULENCE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; CYTOTOXICITY; ENZYME ACTIVATION; ENZYME DEGRADATION; ESCHERICHIA COLI; GENE DELETION; MALE; MASS SPECTROMETRY; MOUSE; MUCUS; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN PURIFICATION; SHIGELLA DYSENTERIAE;

ANIMALS; BUFFERS; DISEASE MODELS, ANIMAL; ESCHERICHIA COLI INFECTIONS; LETHAL DOSE 50; MALE; MASS SPECTROMETRY; MICE; PANCREATIC ELASTASE; PEPTIDES; PHENOTYPE; SHIGA-LIKE TOXIN I; SHIGA-LIKE TOXIN II;

ANIMALIA; BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; EUKARYOTA; NEGIBACTERIA; SHIGELLA DYSENTERIAE;

EID: 0036194663     PISSN: 0950382X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2958.2002.02733.x     Document Type: Article

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