Synergistic effect of theophylline and procaterol on interleukin-5-induced degranulation from human eosinophils

Journal of Asthma

Volumn 39, Issue 1, 2002, Pages 21-27

  Fujisawa, Takao ^a   Kato, Yoshiko ^a   Terada, Akihiko ^a   Iguchi, Kosei ^a   Kamiya, Hitoshi ^a  

^a MIE NATIONAL HOSPITAL   (Japan)

Author keywords

Degranulation; Eosinophil; Interleukin 5; Procaterol; Theophylline

Indexed keywords

DEXAMETHASONE; EOSINOPHIL PROTEIN X; INTERLEUKIN 5; PROCATEROL; THEOPHYLLINE;

ARTICLE; ASTHMA; BRONCHODILATATION; CELL FUNCTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DEGRANULATION; DRUG EFFECT; DRUG POTENTIATION; EOSINOPHIL; HUMAN; HUMAN CELL; RADIOIMMUNOASSAY; SUPERNATANT;

BRONCHODILATOR AGENTS; CELL DEGRANULATION; DEXAMETHASONE; DRUG SYNERGISM; EOSINOPHILS; HUMANS; INTERLEUKIN-5; PROCATEROL; THEOPHYLLINE;

EID: 0036191847     PISSN: 02770903     EISSN: None     Source Type: Journal    
DOI: 10.1081/JAS-120000803     Document Type: Article

References (40)

1. Anti-inflammatory effects of low-dose oral theophylline in atopic asthma
2. Theophylline attenuation of airway responses to allergen: Comparison with cromolyn metered-dose inhaler
3. Theophylline: Potential antiinflammatory effects in nocturnal asthma
4. Immunomodulation by theophylline in asthma. Demonstration by withdrawal of therapy
5. Theophylline - An immunomodulatory role in asthma?
6. Theophylline at therapeutic concentration suppresses PAF-induced upregulation of Mac-1 on human eosinophils
7. The prolonged survival of human eosinophils with intcrleukin-5 and its inhibition by theophylline via apoptosis
8. Low-dose theophylline modulates T-lymphocyte activation in allergen-challenged asthmatics
9. Effects of phosphodiesterase inhibitors on human lung mast cell and basophil function
10. The use of beta-agonists and the risk of death and near death from asthma
11. Added salmeterol versus higher-dose corticosteroid in asthma patients with symptoms on existing inhaled corticosteroid
12. Inhibition of tumor necrosis factor-alpha and interleukin-1beta production by beta-adrenoceptor agonists from lipopolysaccharide-stimulated human peripheral blood mononuclear cells
13. Inhibitory effects of theophylline and procaterol on eosinophil function
14. Mechanisms of eosinophil-associated inflammation
15. IL-5 as a strong secretagogue for human eosinophils
16. Purification of human blood eosinophils by negative selection using immunomagnetic beads
17. Chemokines induce eosinophil degranulation through CCR-3
18. Clinical pharmacokinetics and relative bioavailability of oral procaterol
19. Recombinant human interleukin 5 is an eosinophil differentiation factor but has no activity in standard human B cell growth factor assays
20. Highly purified murine Interleukin 5 (IL-5) stimulates eosinophil function and prolongs in vitro survival: IL-5 as an eosinophil chemotactic factor
21. Regulatory effect of cytokines on eosinophil degranulation
22. IL-5-Dependent conversion of normodense human eosinophils to the hypodense phenotype uses 3T3 fibroblasts for enhanced viability, accelerated hypodensity, and sustained antibody-dependent cytotoxicity
23. Antiinterleukin-5 antibody prevents airway hyperresponsiveness in a murine model of airway sensitization
24. Infiltration of eosinophils into the asthmatic airways caused by interleukin 5
25. Relationship between IL-4 and IL-5 mRNA expression and disease severity in atopic asthma
26. Predominant TH2-like bronchoalveolar T-lymphocyte population in atopic asthma
27. Regulation of Ig-induced eosinophil degranulation by adenosine 3′,5′-cyclic monophosphate
28. Fenoterol and fatal asthma
29. Rebound increase in bronchial responsiveness after treatment with inhaled terbutaline
30. Increased bronchial hyperresponsiveness after inhaling salbutamol during 1 year is not caused by subsensitization to salbutamol
31. Protective and bronchodilator effects of prostaglandin E and salbutamol in aspirin-induced asthma
32. Anti-inflammatory activity of salmeterol: Down-regulation of cytokine production
33. Inhibitory effects of formoterol on platelet-activating factor induced eosinophil chemotaxis and degranulation
34. Regulation of IgE production from human mononuclear cells by β2-adrenoceptor agonists
35. Paradoxical blockade of beta adrenergically mediated inhibition of stimulated eosinophil secretion by salmeterol
36. Long-term effects of inhaled beta 2-agonists on bronchial hyperresponsiveness in asthmatics
37. Ability of inhaled procaterol, a beta 2 adrenoceptor agonist, to attenuate eicosanoid-induced airflow obstruction and airway microvascular leakage
38. Inhaled procaterol inhibits histamine-induced airflow obstruction and microvascular leakage in guinea-pig airways with allergic inflammation
39. Inhibition of interferon-γ production from lymphocytes stimulated with food antigens by a β2-agonist, procaterol, in patients with food-sensitive atopic dermatitis
40. Theophylline and selective. Phosphodiesterase inhibitors as anti-inflammatory drugs in the treatment of bronchial asthma