Variability in glucose transporter-1 levels and hexokinase activity in human melanoma

Melanoma Research

Volumn 12, Issue 1, 2002, Pages 35-43

  Wachsberger, P R ^a   Gressen, E L ^a   Bhala, A ^a   Bobyock, S B ^a   Storck, C ^a   Coss, R A ^a   Berd, D ^a   Leeper, D B ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

Glut 1; Hexokinase; Melanoma

Indexed keywords

COLLAGENASE; DEOXYRIBONUCLEASE; GLUCOSE TRANSPORTER 1; HEXOKINASE; LIQUID NITROGEN; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE;

ADULT; AGED; ARTICLE; CANCER GROWTH; CLINICAL ARTICLE; ENZYME ACTIVITY; ENZYME ASSAY; FEMALE; GENETIC VARIABILITY; GLUCOSE METABOLISM; HUMAN; HUMAN TISSUE; IMMUNOBLOTTING; MALE; MELANOMA; PRIORITY JOURNAL; TUMOR BIOPSY; WESTERN BLOTTING;

ADULT; AGED; AGED, 80 AND OVER; BIOPSY; BLOTTING, WESTERN; DENSITOMETRY; FEMALE; GLUCOSE TRANSPORTER TYPE 1; HEXOKINASE; HUMANS; HYDROGEN-ION CONCENTRATION; IMMUNOBLOTTING; LYMPHATIC METASTASIS; MALE; MELANOMA; MIDDLE AGED; MONOSACCHARIDE TRANSPORT PROTEINS; NADP; SKIN NEOPLASMS;

EID: 0036189504     PISSN: 09608931     EISSN: None     Source Type: Journal    
DOI: 10.1097/00008390-200202000-00006     Document Type: Article

References (54)

1. Growth dynamics of malignant melanomas. Determination of tumor doubling time based on morphometric measurements of roentgen images of lung metastases
2. Establishment and characterization of six human melanoma xenograft lines
3. Current therapy of cutaneous melanoma
4. High aerobic glycolysis of rat hepatoma cells in culture. Role of mitochondrial hexokinase
5. Glycolysis, respiration and anomalous gene expression in experimental hepatomas
6. Functional significance of mitochondrial bound hexokinase in tumor cell metabolism. Evidence for preferred phosphorylation of glucose by intramitochondrially generated ATP
7. Differences in expression and intracellular distribution of hexokinase isenzymes in rat liver cells of different transformation stages
8. Genetic instability induced by the tumor environment
9. Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumors
10. The influence of tumor blood flow and microenvironmental factors on the efficacy of radiation, drugs and localized hyperthermia
11. Changes in glucose transport associated with malignant transformation
12. Overexpression of facilitative glucose transporter genes in human cancer
13. Facilitative glucose transporters
14. Aberrant glycolytic metabolism of cancer cells: A remarkable coordination of genetic, transcriptional, post-translational, and mutational events that lead to a critical role for type II hexokinase
15. Tumor mitochondria and the bioenergetics of tumor cells
16. Hexokinase receptors: Preferential enzyme binding in normal cells to nonmitochondrial sites and in transformed cells to mitochondrial sites
17. Glucose catabolism in cancer cells. Isolation, sequence and activity, of the promoter for type II hexokinase
18. Expression of glucose transporters in head-and-neck tumors
19. Wide expression of the human erythrocyte glucose transporter Glut-1 in human cancers
20. Expression of the human erythrocyte glucose transporter Glut 1 in cutaneous neoplasia
21. Autologous hapten-modified melanoma vaccine as postsurgical adjuvant treatment after resection of nodal metastases
22. Growth and metastasis of fresh human melanoma tissue in mice with severe combined immunodeficiency
23. Flow cytometric determination of the frequency and heterogeneity of expression of human melanoma-associated antigens
24. Protein measurement with the folin phenol reagent
25. Intracellular pH governs the subcellular distribution of hexokinase in a glioma cell line
26. Cleavage of structural proteins during the assembly of the head of bacteriophage T-4
27. Elevated levels of glucose transport and transport messenger RNA are induced by ras or src oncogenes
28. Overexpression of glut-1 glucose transporter in human breast cancer
29. Immunohistochemical localization of glucose transporters in human renal cell carcinoma
30. Hyperglycemia regulates the glucose-transport system of clonal choriocarcinoma, cells in vitro. A potential molecular mechanism contributing to the adjunct effect of glucose in tumor therapy
31. Purification and characterization of mitochondrial bound hexokinase from the highly glycolytic AS-30D rat hepatoma cell line
32. The unique physiology of solid tumors: Opportunities (and problems) for cancer therapy
33. Glut-1 and hexokinase expression: Relationship with fluoro-deoxy-D-glucose uptake in A431 and T47D cells in culture
34. Effects of oxygenation and pH on tumor cell response to alkylating chemotherapy
35. The effect of hypoxia and low pH on the cytotoxicity of chlorambucil
36. Potentiation of DNA-adduct formation and cytotoxicity of platinum-containing drugs by low pH
37. Effect of induced acidosis on cytotoxicity of anticancer drugs
38. Cellular pharmaco-kinetics and cytotoxicity of camptothecin and topotecan at normal and acidic pH
39. Human tumor extracellular pH as a function of blood glucose concentration
40. Effect of hyperglycemia on the thermal response of murine normal and tumor tissues
41. Response of tumours to hyperglycaemia: Characterization, significance and role in hyperthermia
42. Changes in pH and blood flow induced by glucose, and their effects on hyperthermia with or without BCNU in RIF-1 tumours
43. Extracellular pH distribution in human tumours
44. Tumor extracellular pH as a prognostic factor in thermoradiotherapy
45. Glucose catabolism in cancer cells. The type II hexokinase promoter contains functionally active response elements for the tumor suppressor p53
46. Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth
47. Hypoxic stress proteins: Survival of the fittest
48. Hypoxia and mitochondrial inhibitors regulate expression of glucose transporter-1 via distinct Cis-acting sequences
49. Microenvironmental control of gene expression: Implications for tumor angiogenesis, progression, and metastasis
50. Suppression of facilitative glucose transporter 1 mRNA can suppress tumor growth
51. Hexokinase type II: A novel tumor-specific promoter for gene-targeted therapy differentially expressed and regulated in human cancer cells
52. Mutant p53 correlates with reduced expression of thrombospondin-1, increased angiogenesis, and metastatic progression in melanoma
53. Comparison of positron emission tomography scanning and sentinel node biopsy in the detection of micrometastases of primary cutaneous malignant melanoma