Influence of antioxidant depletion on nitrergic relaxation in the pig gastric fundus

British Journal of Pharmacology

Volumn 135, Issue 4, 2002, Pages 917-926

  Colpaert, E E ^a   Timmermans, J P ^b   Lefebvre, R A ^a  

^a GHENT UNIVERSITY   (Belgium)

^b UNIVERSITY OF ANTWERP   (Belgium)

Author keywords

Buthionine sulphoximine; Carmustine; Depletion study; Diethyldithiocarbamate; Ethacrynic acid; Glutathione; Immunohistochemistry; Porcine gastric fundus; Superoxide dismutase

Indexed keywords

2 (4 CARBOXYPHENYL) 4,4,5,5 TETRAMETHYLIMIDAZOLINE 1 OXYL 3 OXIDE; 6 ANILINO 5,8 QUINOLINEQUINONE; ANTIOXIDANT; BUTHIONINE SULFOXIMINE; COPPER ZINC SUPEROXIDE DISMUTASE; DIETHYLDITHIOCARBAMIC ACID; ETACRYNIC ACID; FREE RADICAL; GLUTATHIONE; HYDROQUINONE; HYDROXOCOBALAMIN; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; SCAVENGER;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG EFFECT; DRUG POTENTIATION; DRUG SENSITIVITY; ELECTROSTIMULATION; ENZYME ACTIVITY; ENZYME INHIBITION; IMMUNOHISTOCHEMISTRY; MYENTERIC PLEXUS; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; SMOOTH MUSCLE; STOMACH FUNDUS; SWINE;

AMINOQUINOLINES; ANIMALS; BENZOATES; BUTHIONINE SULFOXIMINE; CARMUSTINE; CHELATING AGENTS; DITIOCARB; ENZYME INHIBITORS; ETHACRYNIC ACID; GASTRIC FUNDUS; GLUTATHIONE; HYDROXOCOBALAMIN; IMIDAZOLES; IMMUNOHISTOCHEMISTRY; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE I; SUPEROXIDE DISMUTASE; SWINE; THIOLESTER HYDROLASES; UBIQUITIN THIOLESTERASE; VASODILATION;

EID: 0036188639     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0704553     Document Type: Article

References (39)

1. Non-adrenergic non-cholinergic nervous control of gastrointestinal motility patterns
2. Decreased aortic glutathione levels may contribute to impaired nitric oxide-induced relaxation in hypercholesterolaemia
3. Nitric oxide as a putative non-adrenergic non-cholinergic inhibitory transmitter in the canine pylorus in vivo
4. Effect of LY83583 on relaxation induced by non-adrenergic non-cholinergic nerve stimulation and exogenous nitric oxide in the rat gastric fundus
5. Influence of S-nitrosothiols and nitrate tolerance in the rat gastric fundus
6. A rapid and sensitive method for the quantitation of microgram quantities of protein using the principle of protein-dye binding
7. Influence of bilirubin and other antioxidants on nitrergic relaxation in the pig gastric fundus
8. Comparison of the pharmacological profile of S-nitrosothiols, nitric oxide and the nitrergic neurotransmitter in the canine ileocolonic junction
9. Effect of thiol modulators and Cu/Zn superoxide dismutase inhibition on nitrergic relaxations in the rat gastric fundus
10. Effects of agents that inactivate free radical NO (NO) on nitroxyl anion-mediated relaxations, and on the detection of NO released from the nitroxyl anion donor Angeli's salt
11. Effects of superoxide anion generators and thiol modulators on nitrergic transmission and relaxation to exogenous nitric oxide in the sheep urethra
12. The nitrergic transmitter of the anococcygeus - NO or not?
13. Biological and pharmacological regulation of mammalian glutathione synthesis
14. Differentiation by hydroquinone of relaxations induced by exogenous and endogenous nitrates in non-vascular smooth muscle: Role of superoxide anions
15. Control of coronary vascular tone by nitric oxide
16. Inactivation of intracellular copper-zinc superoxide dismutase by copper chelating agents without glutathione depletion and methemoglobin formation
17. Effects of pyrogallol, hydroquinone and duroquinone on responses to nitrergic nerve stimulation and NO in the rat anococcygeus muscle
18. Influence of superoxide dismutase inhibition on the discrimination between NO and the nitrergic neurotransmitter in the rat gastric fundus
19. Study of NO and VIP as non-adrenergic non-cholinergic neurotransmitters in the pig gastric fundus
20. Inhibition by ethacrynic acid of NO-mediated relaxations of the rat anococcygeus muscle
21. Comparison of the redox forms of nitrogen monoxide with the nitrergic transmitter in the rat anococcygeus muscle
22. Nitric oxide and vasoactive intestinal polypeptide mediate non-adrenergic, non-cholinergic inhibitory transmission to smooth muscle of the rat gastric fundus
23. Inhibition of relaxations to nitrergic stimulation of the mouse anococcygeus by duroquinone
24. Antioxidant protection of NO-induced relaxations of the mouse anococcygeus muscle against inhibition by superoxide anions, hydroquinone and carboxy-PTIO
25. Release of the antioxidants ascorbate and urate from a nitrergically-innervated smooth muscle
26. Protection of nitrergic transmission by colocalization of neural nitric oxide synthase with copper zinc superoxide dismutase
27. Responses of porcine gastric and duodenal smooth muscle to VIP
28. NANC neurotransmission in the bovine retractor penis muscle is blocked by superoxide anion following inhibition of superoxide dismutase with diethyldithiocarbamate
29. Selective modifiers of glutathione biosynthesis and 'repriming' of vascular smooth muscle photo-relaxation
30. Glutathione metabolism and its selective modification
31. Glutathione
32. Cytoprotection by inhibition of chloride channels: The mechanism of action of glycine and strychnine
33. Glutathione redox cycle regulates nitric oxide-mediated glyceraldehyde-3-phosphate dehydrogenase inhibition
34. Blockade of nitrergic transmission by hydroquinone, hydroxocobalamin and carboxy-PTIO in bovine retractor penis: Role of superoxide anion
35. Nitric oxide mediates inhibitory nerve effects in human esophagus and lower esophageal sphincter
36. Structure-function aspects in the nitric oxide synthases
37. Uptake and glutathione conjugation of ethacrynic acid and efflux of the glutathione adduct by periportal and perivenous rat hepatocytes
38. Accommodation mediated by enteric inhibitory reflexes in the isolated guinea-pig small intestine
39. Targeted gene deletion of heme oxygenase 2 reveals neural role for carbon monoxide