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Volumn 27, Issue 7, 1997, Pages 595-602

Increased activity of platelet-activating factor acetylhydrolase in low- density lipoprotein subfractions induces enhanced lysophosphatidylcholine production during oxidation in patients with heterozygous familial hypercholesterolaemia

Author keywords

Familial hypercholesterolaemia; Low density lipoprotein subfractions; Lysophosphatidylcholine; Oxidation; Platelet activating factor acetylhydrolase

Indexed keywords

1 ALKYL 2 ACETYLGLYCEROPHOSPHOCHOLINE ESTERASE; COPPER ION; HIGH DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN; LYSOPHOSPHATIDYLCHOLINE; SPHINGOMYELIN;

EID: 0030822866     PISSN: 00142972     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2362.1997.1570706.x     Document Type: Article
Times cited : (66)

References (49)
  • 1
    • 0002230202 scopus 로고
    • Familial hypercholesterolemia
    • Scriver CR, Beaudet AL, Sly WS, Vall D, eds. New York: McGraw-Hill
    • Goldstein JL, Brown MS. Familial hypercholesterolemia. In: Scriver CR, Beaudet AL, Sly WS, Vall D, eds. The metabolic basis of inherited disease, 6th edn. New York: McGraw-Hill, 1989;1215-50.
    • (1989) The Metabolic Basis of Inherited Disease, 6th Edn. , pp. 1215-1250
    • Goldstein, J.L.1    Brown, M.S.2
  • 2
    • 0024494608 scopus 로고
    • Genetic aspects of familial hypercholesterolemia and its diagnosis
    • Motulsky AG. Genetic aspects of familial hypercholesterolemia and its diagnosis. Arteriosclerosis 1989;9 (suppl. 1):13-17.
    • (1989) Arteriosclerosis , vol.9 , Issue.1 SUPPL. , pp. 13-17
    • Motulsky, A.G.1
  • 3
    • 0025944056 scopus 로고
    • Risk of fatal heart disease in familial hypercholesterolemia
    • Scientific Steering Committee. Risk of fatal heart disease in familial hypercholesterolemia. Br Med J 1991;303:893-6.
    • (1991) Br Med J , vol.303 , pp. 893-896
  • 4
    • 0026031715 scopus 로고
    • Genetic and environmental factors affecting the incidence of coronary artery disease in heterozygous familial hypercholesterolemia
    • Hill JS, Hayden MR, Frohlich J, Pritchard PH. Genetic and environmental factors affecting the incidence of coronary artery disease in heterozygous familial hypercholesterolemia. Arterioscler Thromb 1991;11:290-7.
    • (1991) Arterioscler Thromb , vol.11 , pp. 290-297
    • Hill, J.S.1    Hayden, M.R.2    Frohlich, J.3    Pritchard, P.H.4
  • 5
    • 0024603895 scopus 로고
    • Beyond cholesterol: Modifications of low density lipoprotein that increase its atherogenicity
    • Steinberg D, Parthasarathy S, Carew TE, Khoo JC, Witzum JL. Beyond cholesterol: modifications of low density lipoprotein that increase its atherogenicity. N Engl J Med 1989;320:915-24.
    • (1989) N Engl J Med , vol.320 , pp. 915-924
    • Steinberg, D.1    Parthasarathy, S.2    Carew, T.E.3    Khoo, J.C.4    Witzum, J.L.5
  • 6
    • 0026333959 scopus 로고
    • Role of oxidized low density lipoprotein in atherogenesis
    • Witzum JL, Steinberg D. Role of oxidized low density lipoprotein in atherogenesis. J Clin Invest 1991;88:1785-92.
    • (1991) J Clin Invest , vol.88 , pp. 1785-1792
    • Witzum, J.L.1    Steinberg, D.2
  • 8
    • 0025633323 scopus 로고
    • Lipoproteins and atherogenesis: Current concepts
    • Steinberg D, Witzum JL. Lipoproteins and atherogenesis: current concepts. JAMA 1990;264:3047-52.
    • (1990) JAMA , vol.264 , pp. 3047-3052
    • Steinberg, D.1    Witzum, J.L.2
  • 9
    • 0000061171 scopus 로고
    • Modification of low density lipoprotein by endothelial cells involves lipid peroxidation and degradation of low density lipoprotein phospholipids
    • Steinbrecher UP, Parthasarathy S, Leak DS, Witzum JL, Steinberg D. Modification of low density lipoprotein by endothelial cells involves lipid peroxidation and degradation of low density lipoprotein phospholipids. Proc Natl Acad Sci USA 1984;81:3883-7.
    • (1984) Proc Natl Acad Sci USA , vol.81 , pp. 3883-3887
    • Steinbrecher, U.P.1    Parthasarathy, S.2    Leak, D.S.3    Witzum, J.L.4    Steinberg, D.5
  • 10
    • 0026781978 scopus 로고
    • Lysophosphatidylcholine, a component of atherogenic lipoproteins, induces mononuclear leukocyte adhesion molecules in cultured human and rabbit arterial endothelial cells
    • Kume N, Cybulsky MI, Gimbrone MA. Lysophosphatidylcholine, a component of atherogenic lipoproteins, induces mononuclear leukocyte adhesion molecules in cultured human and rabbit arterial endothelial cells. J Clin Invest 1992;90:1138-44.
    • (1992) J Clin Invest , vol.90 , pp. 1138-1144
    • Kume, N.1    Cybulsky, M.I.2    Gimbrone, M.A.3
  • 11
    • 0027266301 scopus 로고
    • Effects of lysolipids and oxidatively modified low density lipoprotein on endothelium-dependent relaxation of rabbit aorta
    • Mangin EL, Kugiyama K, Nguy JH, Kerns SA, Henry PD. Effects of lysolipids and oxidatively modified low density lipoprotein on endothelium-dependent relaxation of rabbit aorta. Circ Res 1993;72:161-6.
    • (1993) Circ Res , vol.72 , pp. 161-166
    • Mangin, E.L.1    Kugiyama, K.2    Nguy, J.H.3    Kerns, S.A.4    Henry, P.D.5
  • 12
    • 0024521694 scopus 로고
    • Hydrolysis of phosphatidylcholine during LDL oxidation is mediated by platelet-activating factor acetylhydrolase
    • Steinbrecher UP, Pritchard PH. Hydrolysis of phosphatidylcholine during LDL oxidation is mediated by platelet-activating factor acetylhydrolase. J Lipid Res 1989;30:305-15.
    • (1989) J Lipid Res , vol.30 , pp. 305-315
    • Steinbrecher, U.P.1    Pritchard, P.H.2
  • 13
    • 0028352168 scopus 로고
    • Platelet-activating factor formation during oxidative modification of low density lipoprotein when PAF-acetylhydrolase has been inactivated
    • Liapikos ThA, Antonopoulou S, Karabina S-AP, Tsoukatos DC, Demopoulos CA, Tselepis AD. Platelet-activating factor formation during oxidative modification of low density lipoprotein when PAF-acetylhydrolase has been inactivated. Biochim Biophys Acta 1994;1212:353-60.
    • (1994) Biochim Biophys Acta , vol.1212 , pp. 353-360
    • Liapikos, Th.A.1    Antonopoulou, S.2    Karabina, S.-A.P.3    Tsoukatos, D.C.4    Demopoulos, C.A.5    Tselepis, A.D.6
  • 14
    • 0026659365 scopus 로고
    • PAF-acetylhydrolase: A novel enzyme with biochemical and clinical interest
    • Tselepis AD, Pinckard RN. PAF-acetylhydrolase: A novel enzyme with biochemical and clinical interest. Clin Chem Enzyme Commun 1992;4:279-90.
    • (1992) Clin Chem Enzyme Commun , vol.4 , pp. 279-290
    • Tselepis, A.D.1    Pinckard, R.N.2
  • 15
    • 0025908558 scopus 로고
    • Human plasma platelet-activating factor acetylhydrolase. Oxidatively fragmented phospholipids as substrates
    • Stemler KE, Stafforini DM, Prescott SM, McIntyre TM. Human plasma platelet-activating factor acetylhydrolase. Oxidatively fragmented phospholipids as substrates. J Biol Chem 1991;266:11095-103.
    • (1991) J Biol Chem , vol.266 , pp. 11095-11103
    • Stemler, K.E.1    Stafforini, D.M.2    Prescott, S.M.3    McIntyre, T.M.4
  • 17
    • 0029113036 scopus 로고
    • PAF-degrading acetylhydrolase is preferentially associated with dense LDL and VHDL-1 in human plasma: Catalytic characteristics and relation to the monocyte-derived enzyme
    • Tselepis AD, Dentan C, Karabina S-AP, Chapman MJ, Ninio E. PAF-degrading acetylhydrolase is preferentially associated with dense LDL and VHDL-1 in human plasma: catalytic characteristics and relation to the monocyte-derived enzyme. Arterioscler Thromb Vasc Biol 1995;15:1764-73.
    • (1995) Arterioscler Thromb Vasc Biol , vol.15 , pp. 1764-1773
    • Tselepis, A.D.1    Dentan, C.2    Karabina, S.-A.P.3    Chapman, M.J.4    Ninio, E.5
  • 19
    • 0027938951 scopus 로고
    • Heterogeneity of plasma low-density lipoproteins and atherosclerosis risk
    • Krauss RM. Heterogeneity of plasma low-density lipoproteins and atherosclerosis risk. Curr Opin Lipidol 1994;5:339-49.
    • (1994) Curr Opin Lipidol , vol.5 , pp. 339-349
    • Krauss, R.M.1
  • 20
    • 0027449252 scopus 로고
    • Documented need for more effective diagnosis and treatment of familial hypercholesterolemia according to data from 502 heterozygotes in Utah
    • Williams RR, Schumacher MC, Barlow GK et al. Documented need for more effective diagnosis and treatment of familial hypercholesterolemia according to data from 502 heterozygotes in Utah. Am J Cardiol 1993;72:18D-24D.
    • (1993) Am J Cardiol , vol.72
    • Williams, R.R.1    Schumacher, M.C.2    Barlow, G.K.3
  • 21
    • 0027301629 scopus 로고
    • Diagnosing heterozygous familial hypercholesterolemia using new practical criteria validated by molecular genetics
    • Williams RR, Hunt SC, Schumacher MC et al. Diagnosing heterozygous familial hypercholesterolemia using new practical criteria validated by molecular genetics. Am J Cardiol 1993;72:171-6.
    • (1993) Am J Cardiol , vol.72 , pp. 171-176
    • Williams, R.R.1    Hunt, S.C.2    Schumacher, M.C.3
  • 22
    • 0026069513 scopus 로고
    • Oxidation of lipoprotein Lp(a). A comparison with low-density lipoproteins
    • Sattler W, Kostner GM, Waeg G, Esterbauer H. Oxidation of lipoprotein Lp(a). A comparison with low-density lipoproteins. Biochim Biophys Acta 1991;1081:65-74.
    • (1991) Biochim Biophys Acta , vol.1081 , pp. 65-74
    • Sattler, W.1    Kostner, G.M.2    Waeg, G.3    Esterbauer, H.4
  • 23
    • 33845261493 scopus 로고
    • A rapid method of total lipid extraction and purification
    • Bligh EG, Dyer WJ. A rapid method of total lipid extraction and purification. Can J Biochem Physiol 1959;37:911-17.
    • (1959) Can J Biochem Physiol , vol.37 , pp. 911-917
    • Bligh, E.G.1    Dyer, W.J.2
  • 24
    • 0015348189 scopus 로고
    • Estimation of the concentration of low density lipoprotein cholesterol in plasma without use of the preparative ultracentrifuge
    • Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low density lipoprotein cholesterol in plasma without use of the preparative ultracentrifuge. Clin Chem 1972;18:499-502.
    • (1972) Clin Chem , vol.18 , pp. 499-502
    • Friedewald, W.T.1    Levy, R.I.2    Fredrickson, D.S.3
  • 25
    • 0000711274 scopus 로고
    • Determination of PAF-2 acylhydrolase activity
    • Pinckard RN, Ludwig JC. Determination of PAF-2 acylhydrolase activity (abstract). Fed Proc 1986;45:856.
    • (1986) Fed Proc , vol.45 , pp. 856
    • Pinckard, R.N.1    Ludwig, J.C.2
  • 26
    • 0026657363 scopus 로고
    • The role of lipid peroxidation and antioxidants in oxidative modification of LDL
    • Esterbauer H, Gebicki J, Paul H, Jurgens G. The role of lipid peroxidation and antioxidants in oxidative modification of LDL. Free Rad Biol Med 1992;13:341-90.
    • (1992) Free Rad Biol Med , vol.13 , pp. 341-390
    • Esterbauer, H.1    Gebicki, J.2    Paul, H.3    Jurgens, G.4
  • 27
    • 0029127442 scopus 로고
    • Platelet aggregability to platelet activating factor at rest and after exercise in patients with coronary artery disease
    • Goudevenos J, Tselepis AD, Tsoukatos D, Grekas G, Kritikakos J, Sideris D. Platelet aggregability to platelet activating factor at rest and after exercise in patients with coronary artery disease. Eur Heart J 1995;16:1036-43.
    • (1995) Eur Heart J , vol.16 , pp. 1036-1043
    • Goudevenos, J.1    Tselepis, A.D.2    Tsoukatos, D.3    Grekas, G.4    Kritikakos, J.5    Sideris, D.6
  • 28
    • 0023885652 scopus 로고
    • Activity of platelet-activating factor (PAF) acetylhydrolase in plasma from patients with ischemic cerebrovascular disease
    • Satoh K, Imaizumi T-A, Kawamura Y, Yoshida H, Takamatsu S, Mizono S. Activity of platelet-activating factor (PAF) acetylhydrolase in plasma from patients with ischemic cerebrovascular disease. Prostaglandins 1988;35:685-98.
    • (1988) Prostaglandins , vol.35 , pp. 685-698
    • Satoh, K.1    Imaizumi, T.-A.2    Kawamura, Y.3    Yoshida, H.4    Takamatsu, S.5    Mizono, S.6
  • 29
    • 0024600767 scopus 로고
    • Enhanced degradation of platelet-activating factor in serum from diabetic patients
    • Hofmann B, Ruhling K, Spangenberg P, Ostermann G. Enhanced degradation of platelet-activating factor in serum from diabetic patients. Haemostasis 1989;19:180-4.
    • (1989) Haemostasis , vol.19 , pp. 180-184
    • Hofmann, B.1    Ruhling, K.2    Spangenberg, P.3    Ostermann, G.4
  • 30
    • 0025352277 scopus 로고
    • Release of platelet-activating factor in systemic lupus erythematosus
    • Tetta C, Bussolino F, Modena F et al. Release of platelet-activating factor in systemic lupus erythematosus. Int Arch Allergy Appl Immunol 1990;91:244-56.
    • (1990) Int Arch Allergy Appl Immunol , vol.91 , pp. 244-256
    • Tetta, C.1    Bussolino, F.2    Modena, F.3
  • 32
    • 0023180687 scopus 로고
    • Human plasma platelet-activating factor acetylhydrolase. Purification and properties
    • Stafforini DM, Prescott SM, McIntyre TM. Human plasma platelet-activating factor acetylhydrolase. Purification and properties. J Biol Chem 1987;262:4223-30.
    • (1987) J Biol Chem , vol.262 , pp. 4223-4230
    • Stafforini, D.M.1    Prescott, S.M.2    McIntyre, T.M.3
  • 33
    • 0027027667 scopus 로고
    • The platelet activating factor acetylhydrolase from human plasma prevents oxidative modification of low density lipoprotein
    • Stafforini DM, Zimmerman GA, McIntyre TM, Prescott SM. The platelet activating factor acetylhydrolase from human plasma prevents oxidative modification of low density lipoprotein. Trans Am Assoc Physiol 1993;106:44-63.
    • (1993) Trans Am Assoc Physiol , vol.106 , pp. 44-63
    • Stafforini, D.M.1    Zimmerman, G.A.2    McIntyre, T.M.3    Prescott, S.M.4
  • 34
    • 0025783171 scopus 로고
    • Oxidatively fragmented phosphatidylcholines activate human neutrophils through the receptor for platelet-activating factor
    • Smiley PL, Stremler KE, Prescott SM, Zimmerman GA, McIntyre TM. Oxidatively fragmented phosphatidylcholines activate human neutrophils through the receptor for platelet-activating factor. J Biol Chem 1991;266:11104-10.
    • (1991) J Biol Chem , vol.266 , pp. 11104-11110
    • Smiley, P.L.1    Stremler, K.E.2    Prescott, S.M.3    Zimmerman, G.A.4    McIntyre, T.M.5
  • 35
    • 0028849870 scopus 로고
    • Oxidatively modified LDL contains phospholipids with platelet activating factor-like activity and stimulates the growth of smooth muscle cells
    • Heery JM, Kozak M, Stafforini DM et al. Oxidatively modified LDL contains phospholipids with platelet activating factor-like activity and stimulates the growth of smooth muscle cells. J Clin Invest 1995;96:2322-30.
    • (1995) J Clin Invest , vol.96 , pp. 2322-2330
    • Heery, J.M.1    Kozak, M.2    Stafforini, D.M.3
  • 36
    • 0001096583 scopus 로고
    • Lysophosphatidylcholine: A chemotactic factor for human monocytes and its potential role in atherogenesis
    • Quinn MT, Parthasarathy S, Steinberg D. Lysophosphatidylcholine: a chemotactic factor for human monocytes and its potential role in atherogenesis. Proc Natl Acad Sci USA 1988;85:2805-9.
    • (1988) Proc Natl Acad Sci USA , vol.85 , pp. 2805-2809
    • Quinn, M.T.1    Parthasarathy, S.2    Steinberg, D.3
  • 37
    • 0028349237 scopus 로고
    • Lysophosphatidylcholine transcriptionally induces growth factor gene expression in cultured human endothelial cells
    • Kume N, Gimbrone MA, Jr. Lysophosphatidylcholine transcriptionally induces growth factor gene expression in cultured human endothelial cells. J Clin Invest 1994;93:907-11.
    • (1994) J Clin Invest , vol.93 , pp. 907-911
    • Kume, N.1    Gimbrone Jr., M.A.2
  • 38
    • 0014480993 scopus 로고
    • Lysophosphatidylcholine concentrations and metabolism in aortic intima plus inner media: Effect of nutritionally induced atherosclerosis
    • Portman OW, Alexander M. Lysophosphatidylcholine concentrations and metabolism in aortic intima plus inner media: effect of nutritionally induced atherosclerosis. J Lipid Res 1969;10:158-65.
    • (1969) J Lipid Res , vol.10 , pp. 158-165
    • Portman, O.W.1    Alexander, M.2
  • 39
    • 0028079980 scopus 로고
    • Lysophosphatidylcholine plays an essential role in the mitogenic effect of oxidized low density lipoprotein on murine macrophages
    • Sakai M, Miyazaki A, Hakamata H et al. Lysophosphatidylcholine plays an essential role in the mitogenic effect of oxidized low density lipoprotein on murine macrophages. J Biol Chem 1994;269:31430-5.
    • (1994) J Biol Chem , vol.269 , pp. 31430-31435
    • Sakai, M.1    Miyazaki, A.2    Hakamata, H.3
  • 40
    • 0029130938 scopus 로고
    • Oxidized LDL induces transcription factor activator protein-1 but inhibits activation of nuclear factor-kB in human vascular smooth muscle cells
    • Ares MPS, Kallin B, Eriksson P, Nilson J. Oxidized LDL induces transcription factor activator protein-1 but inhibits activation of nuclear factor-kB in human vascular smooth muscle cells. Arterioscl Thromb Vasc Biol 1995;10:1584-90.
    • (1995) Arterioscl Thromb Vasc Biol , vol.10 , pp. 1584-1590
    • Ares, M.P.S.1    Kallin, B.2    Eriksson, P.3    Nilson, J.4
  • 41
    • 0028269118 scopus 로고
    • PAF-acether-degrading acetylhydrolase in plasma LDL is inactivated by copper- and cell-mediated oxidation
    • Dentan C, Lesnik P, Chapman MJ, Ninio E. PAF-acether-degrading acetylhydrolase in plasma LDL is inactivated by copper- and cell-mediated oxidation. Arterioscler Thromb 1994;14:353-60.
    • (1994) Arterioscler Thromb , vol.14 , pp. 353-360
    • Dentan, C.1    Lesnik, P.2    Chapman, M.J.3    Ninio, E.4
  • 42
    • 0024501678 scopus 로고
    • High-density lipoprotein cholesterol and cardiovascular disease
    • Gordon DJ, Probstfield JL, Garrison RJ et al. High-density lipoprotein cholesterol and cardiovascular disease. Circulation 1989;79:8-15.
    • (1989) Circulation , vol.79 , pp. 8-15
    • Gordon, D.J.1    Probstfield, J.L.2    Garrison, R.J.3
  • 43
    • 0025268435 scopus 로고
    • High density lipoprotein inhibits the oxidative modification of low-density lipoprotein
    • Parthasarathy S, Barnett J, Fong LG. High density lipoprotein inhibits the oxidative modification of low-density lipoprotein. Biochim Biophys Acta 1990;1044:275-83.
    • (1990) Biochim Biophys Acta , vol.1044 , pp. 275-283
    • Parthasarathy, S.1    Barnett, J.2    Fong, L.G.3
  • 44
    • 0028798619 scopus 로고
    • Effect of platelet activating factor-acetylhydrolase on the formation and action of minimally oxidized-low density lipoprotein
    • Watson AD, Navab M, Hama SY et al. Effect of platelet activating factor-acetylhydrolase on the formation and action of minimally oxidized-low density lipoprotein. J Clin Invest 1995;95:774-82.
    • (1995) J Clin Invest , vol.95 , pp. 774-782
    • Watson, A.D.1    Navab, M.2    Hama, S.Y.3
  • 45
    • 0026511875 scopus 로고
    • Susceptibility to low density lipoprotein oxidation and coronary atherosclerosis in man
    • Regenstrom J, Nilsson J, Tomvall P, Landou C, Hamsten A. Susceptibility to low density lipoprotein oxidation and coronary atherosclerosis in man. Lancet 1992;339:1183-5.
    • (1992) Lancet , vol.339 , pp. 1183-1185
    • Regenstrom, J.1    Nilsson, J.2    Tomvall, P.3    Landou, C.4    Hamsten, A.5
  • 46
    • 0026557371 scopus 로고
    • Oxidative status of lipoproteins in coronary disease patients
    • Liu K, Cuddy TE, Pierce GN. Oxidative status of lipoproteins in coronary disease patients. Am Heart J 1992;123:285-9.
    • (1992) Am Heart J , vol.123 , pp. 285-289
    • Liu, K.1    Cuddy, T.E.2    Pierce, G.N.3
  • 47
    • 0029082222 scopus 로고
    • Pravastatin modulates cholesteryl ester transfer from HDL to apoB-containing lipoproteins and lipoprotein subspecies profile in familial hypercholesterolemia
    • Guerin M, Dolphin PJ, Talussot C, Gardette J, Berthezene F, Chapman MJ. Pravastatin modulates cholesteryl ester transfer from HDL to apoB-containing lipoproteins and lipoprotein subspecies profile in familial hypercholesterolemia. Arterioscler Thromb Vasc Biol 1995;15:1359-68.
    • (1995) Arterioscler Thromb Vasc Biol , vol.15 , pp. 1359-1368
    • Guerin, M.1    Dolphin, P.J.2    Talussot, C.3    Gardette, J.4    Berthezene, F.5    Chapman, M.J.6
  • 48
    • 0028907712 scopus 로고
    • Susceptibility of low density lipoprotein to oxidation in familial hypercholesterolemia
    • Raal FJ, Areias AJ, Waisberg R, von Arb M. Susceptibility of low density lipoprotein to oxidation in familial hypercholesterolemia. Atherosclerosis 1995;115:9-15.
    • (1995) Atherosclerosis , vol.115 , pp. 9-15
    • Raal, F.J.1    Areias, A.J.2    Waisberg, R.3    Von Arb, M.4
  • 49
    • 0028604267 scopus 로고
    • The susceptibility of low-density lipoprotein to in vitro oxidation is increased in hypercholesterolemic patients
    • Cominacini L, Pastorino AM, Garbin U et al. The susceptibility of low-density lipoprotein to in vitro oxidation is increased in hypercholesterolemic patients. Nutrition 1994;10:527-31.
    • (1994) Nutrition , vol.10 , pp. 527-531
    • Cominacini, L.1    Pastorino, A.M.2    Garbin, U.3


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