Kinetic characterization and inhibition of the rat MAB elastase-2, an angiotensin I-converting serine protease

Canadian Journal of Physiology and Pharmacology

Volumn 80, Issue 1, 2002, Pages 42-47

  Santos, Carlos F ^a   Paula, Carmem A ^a   Salgado, Maria Cristina O ^a   Oliveira, Eduardo Brandt ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Pro11 D Ala12 Ang I; Angiotensin; CH 5450; Chymase; Elastase 2

Indexed keywords

ANGIOTENSIN; ANGIOTENSIN I; ANGIOTENSIN I [11 PROLINE DEXTRO 12 ALANINE]; ANILIDE; CH 5450; CHYMASE; DIPEPTIDYL CARBOXYPEPTIDASE; ELASTASE II; ELASTASE INHIBITOR; ISOENZYME; N ACETYLALANYLALANYLPROLYLLEUCINE CHLOROMETHYLKETONE; N SUCCINYLALANYLALANYLPROLYLLEUCINE 4 NITROANILIDE; N SUCCINYLALANYLALANYLPROLYLPHENYLALANINE 4 NITROANILIDE; PANCREATIC ELASTASE; SERINE PROTEINASE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CATALYSIS; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INACTIVATION; ENZYME KINETICS; ENZYME PURIFICATION; ENZYME SUBSTRATE COMPLEX; HUMAN; HYDROLYSIS; MESENTERIC ARTERY; NONHUMAN; PRIORITY JOURNAL; PROTEINASE INHIBITION; RAT;

ANGIOTENSIN II; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; ANIMALS; HUMANS; HYDROLYSIS; KINETICS; MESENTERIC ARTERIES; PEPTIDES; PEPTIDYL-DIPEPTIDASE A; PROTEASE INHIBITORS; RATS; SERINE ENDOPEPTIDASES; SERINE PROTEINASE INHIBITORS;

EID: 0036184996     PISSN: 00084212     EISSN: None     Source Type: Journal    
DOI: 10.1139/y02-004     Document Type: Article

References (28)

1. Hypothesis regarding the patho-physiological role of alternative pathways of angiotensin II formation in atherosclerosis
2. Inhibitors of human heart chymase based on a peptide library
3. Direct evidence for the presence of a different converting enzyme in the hamster cheek pouch
4. Substrate specificity of human pancreatic elastase 2
5. Facilitation of noradrenergic transmission by angiotensin in hypertensive rats
6. [Pro11,D-Ala12]angiotensin I has rapid onset vasoconstrictor activity in the cat
7. A novel vascular smooth muscle chymase is upregulated in hypertensive rats
8. Inhibitors of chymase as mast cell-stabilizing agents: Contribution of chymase in the activation of human mast cells
9. Effects of angiotensin II generated by an angiotensin converting enzyme-independent pathway on left ventricular performance in the conscious baboon
10. Pathways for angiotensin II generation in intact tissue: Evidence from comparative pharmacological interruption of the renin system
11. Alternative angiotensin II formation in rat arteries occurs only at very high concentrations of angiotensin I
12. Inhibition of human pancreatic elastase 2 by peptide chloromethyl ketones
13. Increased vascular formation of angiotensin II in one-kidney, one clip hypertension
14. Role of endothelium in angiotensin II formation by the rat aorta and mesenteric arterial bed
15. Hydrolysis of proteins and peptides in a hermetically sealed microcapillary tube: High recovery of labile amino acids
16. Vasoconstrictor action of angiotensin I-convertase and the synthetic substrate (Pro11,D-Ala12)-angiotensin I
17. Role of angiotensin II generated by angiotensin converting enzyme-independent pathways in canine kidney
18. Functional evidence for alternative ANG II-forming pathways in hamster cardiovascular system
19. Marked species-difference in the vascular angiotensin II-forming pathways: Humans versus rodents
20. Purification and substrate specificity of an angiotensin converting elastase-2 from the rat mesenteric arterial bed perfusate
21. Effect of captopril on neurally induced contraction and relaxation of mesenteric arteries of renal hypertensive rats
22. Molecular cloning and sequencing of the cDNA for the rat mesenteric arterial bed elastase-2, an angiotensin II-forming enzyme
23. Rapid equilibrium bireactant and terreactant systems
24. Purification, characterization and substrate specificity of rat pancreatic elastase II
25. Identification of a highly specific chymase as the major angiotensin II-forming enzyme in the human heart
26. Characterization of angiotensin II formation in human isolated bladder by selective inhibitors of ACE and human chymase: A functional and biochemical study
27. Functional and biochemical analysis of angiotensin II-forming pathways in the human heart