Toxicity of uricosuric diuretics in rat hepatocyte culture

Biochemical Pharmacology

Volumn 38, Issue 7, 1989, Pages 1181-1184

  Tolman, Keith G ^a,b   Gray, Phillip D ^a,b   El Masry, Souheir ^a,b   Luther, Robert R ^a,b   Janicki, Robert S ^a,b  

^a UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^b ABBOTT LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 [4 (3 AMINOMETHYL 4 HYDROXYBENZOYL) 2,3 DICHLOROPHENOXY]ACETIC ACID ETHYL ESTER; 8 CHLORO 3 (2 FLUOROPHENYL) 5,6 DIHYDROFURO[3,2 F][1,2]BENZISOXAZOLE 6 CARBOXYLATE POTASSIUM; ETACRYNIC ACID; FUROSEMIDE; INDACRINONE; TIENILIC ACID;

ANIMAL CELL; CELL CULTURE; LIVER TOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT; STRUCTURE ACTIVITY RELATION;

ANIMAL; CELLS, CULTURED; DIURETICS; DRUG EVALUATION, PRECLINICAL; ETHACRYNIC ACID; GLYCOLATES; INDANS; LIVER; MALE; MODELS, BIOLOGICAL; RATS; RATS, INBRED STRAINS; TICRYNAFEN; URICOSURIC AGENTS;

EID: 0024580961     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/0006-2952(89)90266-9     Document Type: Article

References (21)

1. Ticrynafen recall
2. Total ban on tienilic acid (letter) microsomal metabolism of furosemide. Evidence for the nature of the reactive intermediate involved with covalent binding
3. Hepatocellular damage with ethacrynic acid
4. Lack of cytotoxicity of ticrynafen in primary cultures of rat liver cells
5. Inhibition of soluble glutathione S-transferase by diuretic drugs
6. Hepatotoxicity studies with primary cultures of rat liver cells
7. Cytotoxicity of acetaminophen and papaverine in primary cultures of rat hepatocytes
8. Evaluation of the cytotoxicity of tricyclic antidepressants in primary cultures of rat hepatocytes
9. Hepatotoxicity of salicylates in monolayer cell cultures
10. Toxicity ofheparin in isolated rat hepatocytes
11. Hepatotoxicity of valproic acid and other anticonvulsants in rat hepatocyte culture
12. High-yield preparation of isolated rat liver parenchymal cells
13. Parenchymal cells from adult rat liver in non-proliferating monolayer culture
14. A method for viable cell count
15. Trypan blue dye uptake and lactate dehydrogenase in adult rat hepatocytes-Freshly isolated cells, cell suspension and primary monolayer cultures
16. Lactic dehydrogenase activity in blood
17. Effects of ticrynafen on hepatic excretory function in the isolated perfused rat liver
18. Microsomal metabolism of furosemide. Evidence for the nature of the reactive intermediate involved in covalent binding
19. Metabolic activation of furosemide to a chemically reactive hepatotoxic metabolite
20. Adverse reactions to diuretic drugs
21. Drug metabolism in adult rat hepatocytes in primary monolayer culture