The use of mechanistic data and the handling of scientific uncertainty in carcinogen risk assessments

Regulatory Toxicology and Pharmacology

Volumn 35, Issue 1, 2002, Pages 80-94

  Rudén, Christina ^a,b  

^a ROYAL INSTITUTE OF TECHNOLOGY   (Sweden)

^b KAROLINSKA INSTITUTE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

CARCINOGEN; CYTOCHROME P450; DICHLOROACETIC ACID; TRICHLOROETHYLENE;

ARTICLE; CARCINOGENESIS; CARCINOGENICITY; GENOTOXICITY; HUMAN; HYPOTHESIS; KIDNEY TUMOR; LIVER TUMOR; LUNG TUMOR; MUTAGENICITY; NONHUMAN; PEROXISOME; PRIORITY JOURNAL; RISK ASSESSMENT;

EID: 0036180946     PISSN: 02732300     EISSN: None     Source Type: Journal    
DOI: 10.1006/rtph.2001.1508     Document Type: Article

References (56)

1. Liver tumor induction in B6C3F1 mice by dichloroacetate and trichloroacetate
2. The role of dichloroacetate in the hepatocarcinogenicity of trichloroethylene
3. Xenobiotic metabolism in the lung
4. The nephrotoxic and genotoxic N-acetyl-S-dichlorovinyl-L-cysteine is a urinary metabolite after occupational 1,1,2,-trichloroethene exposure in humans
5. Causes of death among laundry and dry cleaning workers
6. Trichloroethylene exposure and specific somatic mutations in patients with renal cell carcinoma
7. Mode of action of liver tumor induction by trichloroethylene and its metabolites, trichloroacetate and dichloroacetate
8. Perturbation of rodent hepatocyte growth control by nongenotoxic hepatocarcinogens: Mechanisms and lack of relevance for human health
9. Metabolism of trichloroethylene by the isolated perfused lung
10. Hepatocarcinogenicity of chloralhydrate, 2-chloroacetaldehyde, and dichloroacetic acid in the male B6C3F1 mouse
11. Acute renal failure due to trichloroethylene poisoning
12. Species and strain sensitivity to the induction of peroxisome proliferation by chloroacetic acids
13. The carcinogenicity of dichloroacetic acid in the male Fischer 344 rat
14. Species differences in carcinogenicity and peroxisome proliferation due to trichloroethylene: A biochemical human hazard assessment
15. Lung injury induced by trichloroethylene
16. Pulmonary toxicity of trichloroethylene in mice: Covalent binding and morphological manifestations
17. Methylene chloride - An inhalation study to investigate pathological and biochemical events occurring in the lungs of mice over an exposure period of 90 days
18. Inhalation carcinogenicity of trichloroethylene in mice and rats
19. Chlorinated hydrocarbon induced peroxisomal enzyme activity in relation to species and organ carcinogenicity
20. A biological database for methylene chloride risk assessment
21. Trichloroethylene-induced mouse lung tumours: Studies of the mode of action and comparisons between species
22. Choosing priority-setting criteria for carcinogens
23. Increased incidence of renal cell tumours in a cohort of cardboard workers exposed to trichloroethylene
24. The carcinogenicity of trichloroethylene and its metabolites, trichloracetic acid and dichloracetic acid, in mouse liver
25. Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators
26. Female laundry and dry cleaning workers in Wisconsin: A mortality analysis
27. Species differences in the metabolism of trichloroethylene to the carcinogenic metabolites trichloroacetate and dichloroacetate
28. Metabolism and lipoperoxidative activity of trichloroacetate and dichloroacetate in rats and mice
29. Idenitification of S-(1,2-dichlorovinyl)glutathione in the blood of human volunteers exposed to trichloroethylene
30. Evaluation of the mutagenicity of chloral hydrate in vitro and in vivo
31. Experimental research on trichloroethylene carcinogenesis
32. Mutagenicity of trichloroethylene and its metabolites: Implications for the risk assessment of trichloroethylene
33. Urinary total protein and β-2-microglobulin in workers exposed to trichloroethylene
34. A mechanism for the development of Clara cell lesions in the mouse lung after exposure to trichloroethylene
35. Species differences in response to trichloroethylene. I. Pharmacokinetics in rats and mice. Toxicol
36. Subclinical effects on liver and kidney function and solvent exposure
37. Peroxisome proliferation and hepatocarcinogenesis
38. Induction of neoplastic lesions in the livers of C57BL × C3HF1 mice by chloral hydrate
39. The use and evaluation of primary data in 29 trichloroethylene cancer risk assessments
40. Interpretations of primary carcinogenicity data in 29 trichloroethylene risk assessments
41. Trichloroethylene exposure in vapour degreasing and the urinary excretion of N-acetyl-β-D-glucosamidase
42. The Clara cell: A comparative ultrastructural study in mammals
43. A pathological study on the toxicity of dichlorovinyl-L-cysteine
44. Renal cell cancer correlated with occupational exposure to trichloroethylene
45. Damage and repair of mouse bronchial epithelium following acute inhalation of trichloroethylene
46. Trichloroacetic acid: Species differences in the stimulation of hepatic DNA synthesis
47. Response of experimental animals to human carcinogens: An analysis based upon the IARC Monographs Programme