Restoration of functional defects in peripheral blood mononuclear cells isolated from cancer patients by thiol antioxidants Alpha-Lipoic Acid and N- Acetyl Cysteine

International Journal of Cancer

Volumn 86, Issue 6, 2000, Pages 842-847

  Mantovani, Giovanni ^a   Macciò, Antonio ^a,b   Melis, Gianbenedetto ^a   Mura, Loredana ^a   Massa, Elena ^a   Mudu, Maria Caterina ^a  

^a UNIVERSITY OF CAGLIARI   (Italy)

^b Carbonia Hospital   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; THIOCTIC ACID;

ANTIOXIDANT ACTIVITY; ARTICLE; CANCER PATIENT; CANCER STAGING; ENDOMETRIUM CANCER; HEAD AND NECK CANCER; HUMAN; HUMAN CELL; LUNG CANCER; MONONUCLEAR CELL; OVARY CANCER; PRIORITY JOURNAL;

EID: 0034659683     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/(sici)1097-0215(20000615)86:6<842::aid-ijc13>3.0.co;2-k     Document Type: Article

References (27)

1. BEHR, J., MAIER, K., DEGENKOLB, B., KROMBACH, F. and VOGELMEIER, C., Antioxidative and clinical effects of high-dose N-acetylcysteine in fibrosing alveolitis. Adjunctive therapy to maintenance immunosuppression. Amer. J. Respir. Crit. Care Med., 156, 1897-1901 (1997).
2. BRENNAN, M.F., Uncomplicated starvation versus cancer cachexia. Cancer Res., 37, 2359-2364 (1997).
3. HAN, D., HANDELMAN, G., MARCOCCI, L., SEN, C.K., ROY, S., KOBUCHI, H., TRITSCHLER, H.J., FLOHE, L. and PACKER, L., Lipoic acid increases de novo synthesis of cellular glutathionc by improving cysteine utilization. Biofactors, 6, 321-338 (1997).
4. HARRIS, C.C., Chemical and physical carcinogenesis: advances and perspectives for the 1990s. Cancer Res., 51, 5023S-5044S (1991).
5. KHANNA, S., ATALAY, M., LODGE, J.K., LAAKSONEN, D.E., ROY, S., HANNINEN, O., PACKER, L. and SEN, C.K., Skeletal muscle and liver lipoyllysine content in response to exercise, training and dietary alpha-lipoic acid supplementation. Biochem. Mol. Biol. Int. 46, 297-306 (1998).
6. KOHNO, T., YAMADA, Y., HATA, T., MORI, H., YAMAMURA, M., TOMONAGA, M., URATA, Y., GOTOM, S. and KONDO, T., Relation of oxidative stress and glutathione synthesis to CD9S (Fas/APO-1)-mediated apoptosis of adult T cell leukemia cells. J. Immunol., 156, 4722-4728 (1996).
7. LAI, P., RABINOWIC, H., CROWLEY-NOWICK, P.A., BELL, M.C., MANTOVANI, G. and WHITESIDE, T.L., Alterations in expression and function of signal transducing proteins in tumor-associated T and NK cells in patients with ovarian carcinoma. Clin. Cancer Res., 2, 161-173 (1996).
8. MAEDA, H. and AKAIKE, T., Review: nitric oxide and oxygen radicals in infection, inflammation and cancer. Biochemistry (Moscow), 63, 854-865 (1998).
9. MANTOVANI, G., MACCIÒ, A., ESU, S., LAI, P., GHIANI, M., TURNU, E., CONTU, G., VOLPE, A. and DEL GIACCO, G.S., Lack of correlation between defective cell-mediated immunity and levels of secreted or circulating cytokines in a study of 90 cancer patients. Int. J. Oncol. 5, 1211-1217 (1994).
10. MANTOVANI, G., MACCIÒ, A., BIANCHI, A., CURRELI, L., GHIANI, M., SANTONA, M.C. and DEL GIAICO, G.S., Megestrol acetate in neoplastic anorexia/cachexia: clinical evaluation and comparison with cytokine levels in patients with head and neck carcinoma treated with neoadjuvant chemotherapy. Int. J. Clin. Lab. Res., 25, 135-141 (1995a).
11. MANTOVANI, G., MACCIÒ A., VERSACE, R., PISANO, M., LAI, P., ESU, S., GHIANI, M., DESSÌ, D., TURNU, E., SANTONA, M.C., CHERCHI, R. and DEL GIACCO, G.S., Tumor-associated lymphocytes (TAL) are competent to produce higher levels of cytokines in neoplastic pleural and peritoneal effusions than those found in sera and are able to release into culture higher levels of IL-2 and IL-6 than those released by PBMC. J. Mol. Med. 73, 409-416 (1995b).
12. MANTOVANI, G., MACCIÒ, A., ESU, S., LAI, P., SANTONA, M.C., MASSA, E., DESSÌ, D., MELIS, G.B. and DEL GIACCO, G.S., Medroxyprogesterone acetate reduces the in vitro production of cytokines and serotonin involved in anorexia/cachexia and emesis by peripheral blood mononuclear cells of cancer patients. Eur. J. Cancer, 33, 602-607 (1997a).
13. MANTOVANI, C., MACCIÒ, A., VERSACE, R., PISANO, M., LAI, P., ESU, S., GHIANI, M., DESSÌ, D., CHERCHI, R., MELIS, G.B. and DEL GIACCO, G.S., Tumor-associated lympho-monocytes from neoplastic effusions are immunologically defective in comparison with patient autologous PBMCs but are capable of releasing high amounts of various cytokines. Int. J. Cancer, 71, 724-731 (1997b).
14. MANTOVANI, G., MACCIÒ, A., LAI, P., MASSA, E., GHIANI, M. and SANTONA, M.C., Cytokinc activity in cancer-related anorexia/cachexia: role of Megestrol Acetate and Medroxyprogesterone Acetate. Semin. Oncol., 25 (Suppl 6), 45-52 (1998a).
15. MANTOVANI, G., MACCIÒ, A., LAI, P., ESU, S., MASSA, E., SANTONA, M.C., MASSA, D., DESSÌ, D. and GHIANI, M., Medroxyprogesterone acetate and megestrol acetate reduce cisplatin-induced serotonin release from human peripheral blood mononuclear cells of cancer patients. Oncol. Rep.. 5, 121-124 (1998b).
16. MANTOVANI, G., MACCIÒ, A., MASSA, E., LAI, P., MANCA, G., MUDU, C., VERSACE, R. and PUSCEDDU, G., Relationships between Fas expression, activation molecule CD25, and functional activity of tumor-associated lymphomonocytes from neoplastic effusions. Oncol. Rep., 6, 235-239 (1999).
17. MATSUMURA, Y., KIMURA, M., YAMAMOTO, T. and MAEDA, H., Involvement of the kinin-generating cascade in enhanced vascular permeability in tumor tissue. Jpn. J. Cancer Res., 79, 1327-1334 (1988).
18. NATHAN, C., Nitric oxide as a secretory product of mammalian cells. FASEB J., 6, 3051-3064 (1992).
19. OLINSKY, R., JARUGA, P. and ZASTAWNY, T.H., Oxidative DNA base modifications as factors in carcinogenesis. Acta Biochim. Pol., 45, 561-572 (1998).
20. PACKER, L., WITT, E.H. and TRITSCHLER, H.J., Alpha-Lipoic acid as a biological antioxidant. Free Radic. Biol. Med., 19, 227-250 (1995).
21. SEMENZATO, G., PIZZOLO, G. and ZAMBELLO, R., The interleukin-2/interleukin-2 receptor system: structural, immunological and clinical features. Int. J. Clin. Lab. Res., 22, 133-142 (1992).
22. SEN, C.K., Redox signaling and the emerging therapeutic potential of thiol antioxidants. Biochem. Pharmacol., 55, 1747-1758 (1998).
23. SEN, C.K., SASHWATI, R. and PACKER, L., Fas mediated apoptosis of human Jurkat T-cells: intracellular events and potentiation by redox-active alpha-lipoic acid. Cell Death Differ., 6, 481-491 (1999).
24. SIES, H., Oxidative stress: oxidants and antioxidants, Exp. Physiol., 82, 291-295 (1997).
25. SMITH, K.A., Interleukin-2: inception, impact and implications. Science, 240, 1169-1174 (1988).
26. WU, J., AKAIKE, T. and MAEDA, H., Modulation of enhanced vascular permeability in tumors by a bradykinin antagonist, a cyclooxygenase inhibitor, and a nitric oxide scavenger. Cancer Res., 58, 159-165 (1998).
27. ZICHE, M., MORBIDELLI, L., CHOUDHURI, R., ZHANG, H.T., DONNINI, S., GRANGER, H.J. and BICKNELL, R., Nitric oxide synthase lies downstream from vascular endothelial growth factor-induced but not basic fibroblast growth factor-induced angiogenesis. J. Clin. Invest., 99, 2625-2634 (1997).