Decreased bone mass and strength in ovariectomized cynomolgus monkeys (Macaca fascicularis)

Calcified Tissue International

Volumn 60, Issue 3, 1997, Pages 265-270

  Jerome, C P ^a   Turner, C H ^b   Lees, C J ^a  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

^b INDIANA UNIVERSITY   (United States)

Author keywords

Bone biomechanics; Bone density; Nonhuman primates; Osteopenia; Osteoporosis

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOMECHANICS; BONE DENSITY; BONE MASS; BONE REMODELING; BONE STRENGTH; CONTROLLED STUDY; FEMALE; MACACA; NONHUMAN; OSTEOPOROSIS; OVARIECTOMY; PRIORITY JOURNAL;

ALKALINE PHOSPHATASE; ANIMALS; BIOLOGICAL MARKERS; BIOMECHANICS; BODY WEIGHT; BONE DENSITY; DISEASE MODELS, ANIMAL; ESTROGENS; FEMALE; FEMUR NECK; LUMBAR VERTEBRAE; MACACA MULATTA; ORGAN SIZE; OSTEOCALCIN; OSTEOPOROSIS; OVARIECTOMY; TENSILE STRENGTH;

EID: 0031044738     PISSN: 0171967X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002239900227     Document Type: Article

References (26)

1. Food and Drug Administration (1994) Guidelines for preclinical and clinical evaluation of agents used in the prevention or treatment of postmenopausal osteoporosis (draft)
2. Reginster JY, Compston JE, Jones EA, Kaufman JM, Audran M, Bouvenot G, Frati L, Mazzuoli G, Gennari C, Lemmel E-M, Ringe JD, Sebert J-L, Vanhaelst L, Avouac B (1995) Recommendations for the registration of new chemical entities used in the prevention and treatment of osteoporosis. Calcif Tissue Int 57:247-250
3. Kimmel DB (1991) The oophorectomized beagle as an experimental model for estrogen-depletion bone loss in the adult human. Cells Mater (suppl 1):75-84
4. Mosekilde L, Weisbrode SE, Safron JA, Stills HF, Jankowsky ML, Ebert DC, Danielsen CC, Søgaard CH, Franks AF, Stevens ML, Paddock CL, Boyce RW (1993) Evaluation of the skeletal effects of combined mild dietary calcium restriction and ovariectomy in Sinclair S-1 minipigs: a pilot study. J Bone Miner Res 8:1311-1321
5. Turner AS, Alvis M, Myers W, Stevens ML, Lundy MW (1995) Changes in bone mineral density and bone-specific alkaline phosphatase in ovariectomized ewes. Bone 17(suppl 4):395S-402S
6. Hornby SB, Ford SL, Mase CA, Evans GP (1995) Skeletal changes in the ovariectomized ewe and subsequent response to treatment with 17β oestradiol. Bone 17(suppl 4):389S-394S
7. Mackey MS, Stevens ML, Ebert DC, Tressler DL, Combs KS, Lowry CK, Smith PN, McOsker JE (1995) The ferret as a small animal model with BMU-based remodeling for skeletal research. Bone 17(suppl 4):191S-196S
8. Balena R, Toolan BC, Shea M, Markatos A, Myers ER, Lee SC, Opas EE, Seedor JG, Klein H, Frankenfield D, Quartuccio H, Fioravanti C, Clair J, Brown E, Hayes WC, Rodan GA (1993) The effects of 2-year treatment with the aminobisphosphonate alendronate on bone metabolism, bone histomorphometry, and bone strength in ovariectomized nonhuman primates. J Clin Invest 92:2577-2586
9. Jerome CP, Carlson CS, Register TC, Bain FT, Jayo MJ, Weaver DS, Adams MR (1994) Bone functional changes in intact, ovariectomized, and ovariectomized, hormone-supplemented adult cynomolgus monkeys (Macaca fascicularis) evaluated by serum markers and dynamic histomorphometry. J Bone Miner Res 9:527-540
10. Weaver DS, Power RA, Jerome CP, Phifer BM, Register TC (1994) The effects of immediate and delayed treatment of ovariectomized cynomolgus monkeys with nandrolone decanoate on densitometry, bone biomarkers, sex steroids and body weight. J Bone Miner Res 9(suppl 1):S393
11. Power RA, Weaver DS, Jerome CP, Phifer BM, Register TC (1994) Histomorphometry and serum bone biomarkers in ovariectomized, nandrolone decanoate-treated cynomolgus monkeys. J Bone Miner Res 9(suppl 1):S393
12. Jerome CP, Kimmel DB, McAlister JA, Weaver DS (1986) Effects of ovariectomy on iliac trabecular bone in baboons (Papio anubis). Calcif Tissue Int 39:206-208
13. Thompson DD, Seedor JG, Quartuccio H, Solomon C, Fioravanti C, Davidson J, Klein H, Jackson R, Clair J, Frankenfield D, Brown E, Simmons HA, Rodan GA (1992) The bisphosphonate, alendronate, prevents bone loss in ovariectomized baboons. J Bone Miner Res 7:951-960
14. Jerome CP, Lees CJ, Weaver DS (1995) Development of osteopenia in ovariectomized cynomolgus monkeys (Macaca fascicularis). Bone 17(suppl 4):403S-408S
15. Jayo MJ, Rankin SE, Weaver DS, Carlson CS, Clarkson TB (1991) Accuracy and precision of lumbar bone mineral content by dual-energy x-ray absorptiometry in live female monkeys. Calcif Tissue Int 49:438-440
16. Turner CH, Burr DB (1993) Basic biomechanical measurements of bone: a tutorial. Bone 14:595-608
17. Sokal RR, Rohlf FJ (1981) Biometry: the principles and practice of statistics in biological research, 2nd ed. W.H. Freeman & Co., New York, pp 262-264
18. Horsman A, Simpson M, Kirby PA, Nordin BEC (1977) Non-linear bone loss in oophorectomized women. Br J Radiol 50: 504-506
19. Christiansen C, Christensen MS, McNair P, Hagen C, Stocklund K-E, Transbol IB (1980) Prevention of early postmenopausal bone loss: controlled 2-year study in 315 normal females. Eur J Clin Invest 10:273-279
20. Cann CE, Genant HK, Ettinger B, Gordan GS (1980) Spinal mineral loss in oophorectomized women. JAMA 244:2056-2059
21. Lindsay R, Aitken JM, Anderson JB, Hart DM, MacDonald EB, Clarke AC (1976) Long-term prevention of postmenopausal osteoporosis by estrogen. Lancet 1:1038-1041
22. Ettinger B, Genant HK, Cann CE (1985) Long-term estrogen therapy prevents bone loss and fracture. Ann Intern Med 102: 319-324
23. Kasra M, Grynpas MD (1994) Effect of long-term ovariectomy on bone mechanical properties in young female cynomolgus monkeys. Bone 15:557-561
24. Mann DR, Rudman CG, Akinbami MA, Gould KG (1992) Preservation of bone mass in hypogonadal female monkeys with recombinant human growth hormone administration. J Clin Endocrinol Metab 74:1263-1269
25. Jayo MJ, Jerome CP, Lees CJ, Rankin SE, Weaver DS (1994) Bone mass in female cynomolgus macaques: a cross-sectional and longitudinal study by age. Calcif Tissue Int 54:231-236
26. Pettifor JM, Marie PJ, Sly MR, du Bruyn DB, Ross F, Isdale JM, de Klerk WA, van der Walt WH (1984) The effect of differing dietary calcium and phosphorus contents on mineral metabolism and bone histomorphometry in young vitamin D-replete baboons. Calcif Tissue Int 36:668-676