Hypothalamic 5α-reductase and 3α-oxidoreductase activity in the male rat

Journal of Steroid Biochemistry and Molecular Biology

Volumn 80, Issue 1, 2002, Pages 91-98

  Gao, C Q ^a   Dhooge, W S ^a   Kaufman, J M ^a   Weyne, J J ^a   Eechaute, W P ^a  

^a GHENT UNIVERSITY   (Belgium)

Author keywords

GC MS analysis; Hypothalamic enzyme activity; Progesterone

Indexed keywords

3ALPHA DIHYDROPROGESTERONE; 3ALPHA HYDROXY 5ALPHA PREGNAN 20 ONE; 5ALPHA PREGNANE 3,20 DIONE; CARBON 14; ESTRONE; FOLLITROPIN; GONADOTROPIN; LUTEINIZING HORMONE; OXIDOREDUCTASE; PROGESTERONE DERIVATIVE; STEROID 3ALPHA REDUCTASE; STEROID 5ALPHA REDUCTASE; TESTOSTERONE; UNCLASSIFIED DRUG;

ADRENALECTOMY; ANIMAL TISSUE; ARTICLE; CASTRATION; CONTROLLED STUDY; ENZYME ACTIVITY; ESTRONE BLOOD LEVEL; FOLLITROPIN BLOOD LEVEL; GONADOTROPIN RELEASE; HORMONAL REGULATION; HORMONE ACTION; HYPOTHALAMUS; IN VITRO STUDY; INCUBATION TIME; LUTEINIZING HORMONE BLOOD LEVEL; MALE; MASS SPECTROMETRY; METABOLITE; NONHUMAN; PROGESTERONE BLOOD LEVEL; RAT; TESTOSTERONE BLOOD LEVEL;

EID: 0036177130     PISSN: 09600760     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-0760(01)00168-6     Document Type: Article

References (37)

1. Testosterone 5α-reductase activity in the rat brain is highly concentrated in white matter structures and in purified myelin sheats of axons
2. 5α-Reductase activity in isolated and cultured neuronal and glial cells of the rat
3. Testosterone metabolism in peripheral nerves: Presence of 5α-reductase 3α-hydroxysteroid-dehydrogenase enzymatic system in the sciatic nerve of adult and aged rats
4. Testosterone metabolism in brain cells and membranes
5. Neurosteroids: 3α-hydroxy-5α-pregnan-20-one and its precursors in the brain, plasma and steroidogenic glands of male and female rats
6. Androgen and progesterone metabolism in the central and the peripheral nervous system
7. Metabolism of progesterone in mouse brain
8. Biosynthesis and assay of neurosteroids in rats and mice functional correlates
9. Progesterone-transforming enzyme activity in the hypothalamus of the male rat
10. The 5α-reduction of testosterone in the neuroendocrine structures: Biochemical and physiological implications
11. Distribution and ontogeny of 3α-hydroxysteroide-hydrogenase in the rat brain
12. Regional distribution of cytosolic and particulate 5α-dihy-droprogesterone 3α-hydroxysteroid oxidoreductases in female rat brain
13. Steroid metabolism in the mammalian brain: 5α-reduction and aromatization
14. Androgen-activating enzymes in the central nervous system
15. Selective suppression of follicle stimulating hormone secretion in anterior pituitary cells by gonadal steroid 3α-hydroxy-4-pregnen-20-one
16. Neurosteroids: A new function in the brain
17. FSH regulating steroid produced by hypothalamus and pituitary
18. Brain 5α-reductase: Cellular, enzymatic and molecular perspectives and implications for biological function
19. Neurosteroids: Biochemistry, modes of action and clinical relevance
20. Suppression of follicle stimulating hormone by the gonadal- and neurosteroid-3α-hydroxy-4-pregnen-20-one involves actions at the level of the gonadotrope membrane/calcium channel
21. Emmerging diversities in the mechanism of action of steroid hormones
22. Gonadal steroids promote interactive communication
23. Neurosteroid antagonists of the GABAA receptors
24. Sex differences and hormonal control of testosterone metabolism in rat pituitary and brain
25. Altered brain and pituitary androgen metabolism by prenatal, perinatal or pre- and postnatal finasteride, flutamide or dihydrotestosterone treatment in juvenile male rats
26. Age-related changes in brain and pituitary 5α-reductase with finasteride (pro-scar) treatment
27. Expression of neural 5α-reductase messenger ribonucleic acid: Comparison to 5α-reductase activity during prenatal development in the rat
28. Kinetic properties of the 5α-reductase of testosterone in the purified myelin, in the subcortical white matter and in the cerebral cortex of the male rat brain
29. Pituitary and brain 5α-reductase messenger RNA levels in control, castrated, and dihydrotestosterone-treated rats
30. Estrogen levels in immature female rats: True or spurious-ovarian or adrenal?
31. The 5α-reductase in the central nervous system: Expression and modes of control
32. Neurosteroids: 3α-hydroxy-5α-pregnan-20-one and its precursors in the brain, plasma and steroidogenetic glands of male and female rats
33. Gas chromatographic-mass-fragmentographic quantitation of 3α-hydroxy-5α-pregnan-20-one (allopregnanolone) and its precursors in blood and brain of adrenalectomized and castrated rats
34. Neurosteroids: Biosynthesis and function
35. Steroid metabolism and effects in central and peripheral glial cells
36. Steroid 5α-reductase: Two genes/two enzymes
37. Non-genomic actions of steroids on gonadotropin release