Fosfomycin inhibits neutrophil function via a protein kinase C-dependent signaling pathway

International Immunopharmacology

Volumn 2, Issue 4, 2002, Pages 511-518

  Hamada, Minako ^a   Honda, Junichi ^a   Yoshimuta, Taro ^a   Fumimori, Takehide ^a   Okamoto, Masaki ^a   Aizawa, Hisamichi ^a  

^a KURUME UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Fosfomycin; Macrocyte function associated antigen 1 (MAC 1); Polymorphonuclear leukocyte; Protein kinase C; Respiratory burst

Indexed keywords

CELL ADHESION MOLECULE; CHEMOTACTIC PEPTIDE; EPITOPE; FORMYLMETHIONYLLEUCYLPHENYLALANINE; FOSFOMYCIN; PHORBOL 12 ACETATE 13 MYRISTATE; PROTEIN KINASE C;

ARTICLE; CELL FUNCTION; CELL STIMULATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; FLOW CYTOMETRY; HUMAN; HUMAN CELL; NEUTROPHIL; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR UPREGULATION; RESPIRATORY BURST;

ANTI-BACTERIAL AGENTS; ANTIGENS, CD11B; DOSE-RESPONSE RELATIONSHIP, DRUG; FLOW CYTOMETRY; FOSFOMYCIN; GENE EXPRESSION REGULATION; HUMANS; NEUTROPHILS; PROTEIN KINASE C; RESPIRATORY BURST; SIGNAL TRANSDUCTION;

EID: 0036175955     PISSN: 15675769     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1567-5769(01)00194-1     Document Type: Article

References (31)

1. The mechanism of action of fosfomycin (phosphonomycin)
2. Characterisation of spontaneous fosfomycin (phosphonomycin)-resistant cells of Escherichia coli B in vitro
3. Immunosuppressive activity of fosfomycin on human T-lymphocyte function in vitro
4. Immunomodulatory effect of fosfomycin on human B-lymphocyte function
5. In vitro effects of phosphomycin on intracellular cyclic nucleotides and histamine releases
6. Fosfomycin inhibition of pulmonary histamine release induced by aminoglycosides
7. Fosfomycin (FOM: 1R-2S-epoxypropylphosphonic acid) suppresses the production of IL-8 from monocytes via the suppression of neutrophil function
8. Cell biology of phagocyte migration from bone marrow, out of the blood stream, and across epithelium
9. Oxygen-dependent microbial killing by phagocytes
10. Adhesion molecules and inflammatory injury
11. Modulatory effect of antibiotics on cytokine production by human monocytes in vitro
12. Fosfomycin alters lipopolysaccharide-induced inflammatory cytokine production in mice
13. Tissue concentration of fosfomycin
14. Pharmacokinetics of fosfomycin
15. Activation of the respiratory burst oxidase in neutrophils on the role of membrane-derived second messengers, calcium, and protein kinase C
16. Activation of the respiratory burst and tyrosine phosphorylation of proteins in human neutrophils: No direct relationship and involvement of protein kinase C-dependent and independent signaling pathways
17. Acute regulation of glucose transport after activation of human peripheral blood neutrophils by phorbol myristate acetate, fMLP, and granulocyte-macrophage colony-stimulating factor
18. Selective inhibition of human neutrophil functional responsiveness by erbstain, an inhibitor of tyrosine protein kinase
19. Stimulation of the neutrophil respiratory burst by formyl peptides is primed by a protein kinase inhibitor, staurosporine
20. Staurosporine inhibits the respiratory burst and induces exocytosis in human neutrophils
21. Effect of a selective protein kinase C inhibitor, Ro 31-8425, on Mac-1 expression and adhesion of human neutrophils
22. Transient adhesion of neutrophils to endothelium
23. The role of protein kinase C activation and inositol phosphate production in the regulation of cell-surface expression of MAC-1 by complement fragment C5a
24. Role of rho in chemoattractant-activated leukocyte adhesion through integrins
25. Activation-dependent proteolytic degradation of polymorphonuclear CD11b
26. Protein kinase C isotypes and signaling in neutrophils: Differential substrate specificities of a translocatable calcium- and phospholipid-dependent beta-protein kinase C and a phospholipid-dependent protein kinase, which is inhibited by long chain fatty acyl coenzyme A
27. Protein kinase C isoforms in human neutrophil cytoplasts
28. Immunochemical identification and translocation of protein kinase C zeta in human neutrophils
29. Protein kinase C-β contributes to NADPH oxidase activation in neutrophils
30. Superoxide production in human neutrophils: Evidence for signal redundancy and the involvement of more than one PKC isoenzyme class
31. Immunomodulating effect of fosfomycin on gut-derived sepsis caused by Pseudomonas aeruginosa in mice