Pharmacokinetic study of a new ibuprofen 600mg plus codeine 30mg combination versus ibuprofen or codeine alone in single oral doses in healthy volunteers

Clinical Drug Investigation

Volumn 22, Issue 1, 2002, Pages 41-49

  Portoles A ^a   Vargas, E ^a   Burgos, A ^b   Moreno, E ^b   Garcia M ^a   Terleira, A ^a   Caturla, M C ^c   Moreno, A ^a  

^a HOSPITAL CLÍNICO SAN CARLOS   (Spain)

^b Laboratorios Knoll SA   (Spain)

^c MCC Analitica   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

CODEINE; IBUPROFEN;

ABDOMINAL PAIN; ADULT; AREA UNDER THE CURVE; ARTICLE; ASTHENIA; BIOEQUIVALENCE; BLOOD SAMPLING; CALCULATION; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DIARRHEA; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG FORMULATION; DRUG MIXTURE; DRUG RELEASE; FEMALE; HEADACHE; HUMAN; HUMAN EXPERIMENT; MALE; NAUSEA; NORMAL HUMAN; PHARMACOKINETICS; PHASE 1 CLINICAL TRIAL; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; TABLET; VERTIGO;

EID: 0036175061     PISSN: 11732563     EISSN: None     Source Type: Journal    
DOI: 10.2165/00044011-200222010-00006     Document Type: Article

References (13)

1. Update on ibuprofen
2. A double-blind placebo-controlled comparison of three ibuprofen-codeine combinations and aspirin
3. Codeine 20 mg increases pain relief from ibuprofen 400mg after third molar surgery. A repeat-dosing comparison of ibuprofen-codeine combination
4. Determination of codeine in human plasma by high-performance liquid chromatography with fluorescence detection
5. Pharmacokinetic evaluation of two ibuprofen-codeine combinations
6. Comparative bioavailability study of codeine and ibuprofen after administration of the two products alone or in association to healthy volunteers
7. Comparative bioavailability of two tablet formulations of ibuprofen
8. Bioavailability of three commercial preparations of ibuprofen 600 mg
9. Comparative single-dose bioavailability study of two oral formulations of ibuprofen in healthy volunteers
10. Clinical pharmacokinetics of ibuprofen. The first 30 years
11. Pharmacokinetics of codeine after single- and multiple-oral-dose administration to normal volunteers