Comparative single-dose bioavailability study of two oral formulations of ibuprofen in healthy volunteers

Clinical Drug Investigation

Volumn 21, Issue 5, 2001, Pages 383-389

  Portoles A ^a,b   Vargas, E ^a,b   Garcia M ^a,b   Terleira, A ^a,b   Rovira, M ^a,b   Caturla, M C ^a,b   Moreno, A ^a,b  

^a HOSPITAL CLÍNICO SAN CARLOS   (Spain)

^b MCC Analitica   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ALGIDRIN; IBUPROFEN;

ADULT; ANALGESIA; AREA UNDER THE CURVE; ARTICLE; CLINICAL TRIAL; CONCENTRATION RESPONSE; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOSE RESPONSE; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG FORMULATION; DRUG RELEASE; FEMALE; FEVER; HUMAN; HUMAN EXPERIMENT; HUMAN TISSUE; MALE; NORMAL HUMAN; PHASE 1 CLINICAL TRIAL; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL;

EID: 0035007511     PISSN: 11732563     EISSN: None     Source Type: Journal    
DOI: 10.2165/00044011-200121050-00008     Document Type: Article

References (5)

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2. Martin W, Koselowske G, Toberich H, et al. Pharmacokinetics and absolute bioavailability of ibuprofen after oral administration of ibuprofen lysine in man. Biopharm Drug Dispos 1990; 11: 265-78
3. Geisslinger G, Dietzel K, Bezler H, et al. Therapeutically relevant differences in the pharmacokinetic and pharmaceutical behavior of ibuprofen lysinate as compared to ibuprofen acid. Int J Clin Pharmacol Ther Toxicol 1989; 27: 324-8
4. Schettler T, Paris S, Pellett M, et al. Comparative pharmacokinetics of two fast-dissolving oral ibuprofen formulations and a regular-release ibuprofen tablet in healthy volunteers. Clin Drug Invest 2001; 21: 73-8
5. Jamali F, Mehvar R, Russell AS, et al. Human pharmacokinetics of ibuprofen enantiomers following different doses and formulations: intestinal chiral inversion. J Pharm Sci 1992; 81:221-5