Studies on the biosynthesis of epothilones: Hydroxylation of epo A and B to epothilones E and F

Journal of Antibiotics

Volumn 55, Issue 1, 2002, Pages 41-45

  Gerth, Klaus ^a   Steinmetz, Heinrich ^a   Höfle, Gerhard ^a   Reichenbach, Hans ^a  

^a HELMHOLTZ CENTRE FOR INFECTION RESEARCH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

EPOTHILONE A; EPOTHILONE B; EPOTHILONE DERIVATIVE; EPOTHILONE E; EPOTHILONE F; ESTERASE; LACTONE; THIAZOLE; UNCLASSIFIED DRUG; UNSPECIFIC MONOOXYGENASE;

ARTICLE; BACTERIAL GROWTH; BIOSYNTHESIS; BIOTRANSFORMATION; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DEGRADATION; DRUG ISOLATION; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME SUBSTRATE; HYDROXYLATION; MYXOCOCCALES; NONHUMAN; PRIORITY JOURNAL; STEADY STATE;

SORANGIUM CELLULOSUM;

EID: 0036171952     PISSN: 00218820     EISSN: None     Source Type: Journal    
DOI: 10.7164/antibiotics.55.41     Document Type: Article

References (6)

1. Studies on the biosynthesis of epothilones: The biosynthetic origin of the carbon skeleton
2. Studies on the biosynthesis of epothilones: The PKS and epothilone C/D monooxygenase
3. Neue Epothilone-Nebenkomponenten
4. N-Oxidation of epothilone A-C and O-acyl rearrangement to C-19- and C21-substituted epothilones
5. The soraphens: A family of novel antifungal compounds from Sorangium cellulosum (Myxobacteria)
6. Imidazole antimycotics inhibitors of cytochrome P450 increase phophatidyl-serine synthesis similar to K(+)-channel blockers in Jurkat T cells