Studies on the biosynthesis of epothilones: The PKS and epothilone C/D monooxygenase

Journal of Antibiotics

Volumn 54, Issue 2, 2001, Pages 144-148

  Gerth, K ^a   Steinmetz, H ^a   Hofle G ^a   Reichenback, H ^a  

^a HELMHOLTZ CENTRE FOR INFECTION RESEARCH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CARBON 14; DRUG METABOLIZING ENZYME; EPOTHILONE A; EPOTHILONE B; EPOTHILONE C; EPOTHILONE D; EPOTHILONE DERIVATIVE; HYDROXYL GROUP; MALONYL COENZYME A; METHANOL; NEW DRUG; NITROGEN; OXYGEN; POLYKETIDE SYNTHASE; PROPIONIC ACID; RESIN; SODIUM CHLORIDE; STARCH; TETRACYCLINE; UNCLASSIFIED DRUG; UNSPECIFIC MONOOXYGENASE;

ANTIBIOTIC BIOSYNTHESIS; ARTICLE; CHEMICAL ANALYSIS; CHEMICAL COMPOSITION; COMPETITIVE INHIBITION; CONTROLLED STUDY; DRUG ISOLATION; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME ACTIVITY; FUNGUS MUTANT; MYXOCOCCALES; NONHUMAN; PRIORITY JOURNAL; STRUCTURE ANALYSIS;

EID: 0035080042     PISSN: 00218820     EISSN: None     Source Type: Journal    
DOI: 10.7164/antibiotics.54.144     Document Type: Article

References (8)

1. Epothilons A and B: Antifungal and cytotoxic compounds from Sorangium cellulosum (Myxobacteria) production, physico-chemical and biological properties
2. Studies on the biosynthesis of epothilons: The biosynthetic origin of the carbon skeleton
3. The biosynthetic gene cluster for the microtubule stabilizing agents epothilones A and B from Sorangium cellulosum So ce90
4. Cloning and heterologous expression of the epothilone gene cluster