Trophoblasts are productively infected by CD4-independent isolate of HIV type 1

AIDS Research and Human Retroviruses

Volumn 18, Issue 1, 2002, Pages 13-17

  Al Harthi, Lena ^a   Guilbert, Larry J ^b   Hoxie, James A ^c   Landay, Alan ^a  

^a RUSH UNIVERSITY MEDICAL CENTER   (United States)

^b UNIVERSITY OF ALBERTA   (Canada)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CHEMOKINE RECEPTOR CCR5; CHEMOKINE RECEPTOR CXCR4; GAG PROTEIN; VIRUS DNA;

ARTICLE; CELL SURFACE; DISEASE TRANSMISSION; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; REGULATORY MECHANISM; TROPHOBLAST; VIRUS ISOLATION; VIRUS PURIFICATION; VIRUS STRAIN;

ANTIGENS, CD4; CELLS, CULTURED; COCULTURE TECHNIQUES; DNA, VIRAL; GENES, GAG; GENES, POL; HIV CORE PROTEIN P24; HIV INFECTIONS; HIV-1; HUMANS; RECEPTORS, CCR5; RECEPTORS, CXCR4; TROPHOBLASTS;

EID: 0036170123     PISSN: 08892229     EISSN: None     Source Type: Journal    
DOI: 10.1089/088922202753394673     Document Type: Article

References (29)

1. A prospective study of infants born to women seropositive for human immunodeficiency virus type 1
2. Perinatal transmission of the human immuno-deficiency virus type 1 to infants of seropositive women in Zaire
3. Rate transmission of human immunodeficiency virus type 1 infection from mother to child and short-term outcome of neonatal infection. Results of a prospective cohort study
4. HIV in pregnant women and their offspring: Evidence for late transmission
5. Vertical transmission of HIV-1: Lack of detectable virus in peripheral blood cells of infected children at birth
6. The sensitivity of HIV-1 DNA polymerase chain reaction in the neonatal period and the relative contributions of intra-uterine and intra-partum transmission
7. The role of obstetric interventions in the prevention of pediatric human immunodeficiency virus infection
8. Timing of mother-to-child HIV-1 transmission depends on maternal status
9. Kinetics of HIV infection of human placental syncytiotrophoblast cultures: An ultrastructural and immunocytochemical study
10. Susceptibility of cultured human trophoblasts to infection with human immunodeficiency virus type 1
11. Immunohistochemical localization of human immunodeficiency virus p24 antigen in placental tissue
12. Placental trophoblasts resist infection by multiple human immunodeficiency virus (HIV) type 1 variants even with cytomegalovirus coinfection but support HIV replication after provirus transfection
13. Localization of human immunodeficiency virus core antigen in term human placentas
14. Human immunodeficiency virus type 1 infection of human placental macrophages in vitro
15. Expression of functional chemokine receptors of human placental cells
16. Stable exposure of the coreceptor-binding site in a CD4-independent HIV-1 envelope protein
17. Determinants of CD4 independence for a human immunodeficiency virus type 1 variant map outside regions required for coreceptor specificity
18. Pregnancy hormones, estrogen and progesterone, prevent HIV-1 synthesis in monocytes but not in lymphocytes
19. Effect of human chorionic go-nadotropin (hCG) on reverse transcriptase activity in HIV-1 infected lymphocytes and monocytes
20. Inhibitory effect of human chorionic gonadotropin (hCG) on HIV-1 transmission from lymphocytes to trophoblasts
21. Human immunodeficiency virus type 1 infection of choriocarcinoma-derived trophoblasts
22. The role of carboxy-terminal portion of beta subunit of human chorionic gonadotropin in human immunodeficiency virus infection
23. Basal and Tat-transactivated expression from the human immuno-deficiency virus type 1 long terminal repeat in human placental trophoblast rules out promoter-enhancer activation as the partial block to viral replication
24. Relationships between CD4-independence, neutralization sensitivity and exposure of a CD4-induced epitope in an HIV-1 envelope protein
25. Increased neutralization sensitivity of CD4-independent human immunodeficiency virus variants
26. Primary human immunodeficiency virus type 2 (HIV-2) isolates infect CD4-negative cells via CCR5 and CXCR4: Comparison with HIV-1 and simian immunodeficiency virus and relevance to cell tropism in vivo
27. Antibody-dependent enhancement of HIV-1 infection in human term syncytiotrophoblast cells cultured in vitro
28. Human trophoblast cells express CD4 and are permissive for productive infection with HIV-1
29. Cell-to-cell contact results in a selective translocation of maternal human immunodeficiency virus type 1 quasi-species across a trophoblastic barrier by both transcytosis and infection