Effective local control of malignant melanoma by intratumoural injection of a beta-emitting radionuclide

European Journal of Nuclear Medicine

Volumn 29, Issue 2, 2002, Pages 221-230

  Lee, Jong ^a   Yang, Woo ^a   Lee, Min Geol ^a   Ryu, Young ^a   Park, Jeon ^a   Shin, Kyoo Ho ^a   Kim, Gwi ^a   Suh, Chang ^a   Seong, Jin ^a   Han, Byoung ^b   Choi, Chang ^c   Kim, Eun Hee ^c   Kim, Kyung ^d   Park, Kyung ^d  

^a Yonsei University College of Medicine   (South Korea)

^b Yonsei University   (South Korea)

^c Korea Cancer Center Hospital   (South Korea)

^d Korea Atomic Energy Research Institute   (South Korea)

Author keywords

Holmium 166; Intratumoural injection; Malignant melanoma; Radiation induced cell death; Unsealed beta emitter

Indexed keywords

ANTINEOPLASTIC AGENT; CYCLIN D1; CYCLINE; HOLMIUM 166; MESSENGER RNA; PROTEIN BAX; PROTEIN P21; PROTEIN P53; RADIOISOTOPE; UNCLASSIFIED DRUG; HOLMIUM;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CANCER CONTROL; CANCER INHIBITION; CANCER SURVIVAL; CELL DEATH; CELL NUCLEUS; CELL SWELLING; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; DRUG MEGADOSE; FLOW CYTOMETRY; IMMUNOHISTOCHEMISTRY; INOCULATION; MELANOMA; MELANOMA CELL; MOUSE; NICK END LABELING; NONHUMAN; PROTEIN ANALYSIS; PROTEIN EXPRESSION; RADIATION DOSE; RADIATION RESPONSE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STAINING; SURVIVAL TIME; TUMOR NECROSIS; TUMOR VOLUME; DRUG HALF LIFE; DRUG RESPONSE; IRRADIATION; MELANOMA B16; NECROSIS; THERAPY EFFECT;

ANIMALS; AUTORADIOGRAPHY; BCL-2-ASSOCIATED X PROTEIN; BETA RAYS; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLINS; GENES, P53; HOLMIUM; INJECTIONS, INTRALESIONAL; MELANOMA, EXPERIMENTAL; MICE; MICE, INBRED C57BL; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; RADIOISOTOPES; RADIONUCLIDE IMAGING; RNA, MESSENGER; RNA, NEOPLASM; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0036169437     PISSN: 03406997     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00259-001-0696-y     Document Type: Article

References (34)

1. Epidemiology of malignant melanoma
2. Surgical issues in the management of melanoma
3. The National Cancer Data Base - Report on melanoma
4. Adjuvant therapy for melanoma
5. The radiation response of human malignant melanoma cells grown in vitro
6. The radioresponsiveness of melanoma
7. Radiation therapy for malignant melanoma
8. Clinical radiobiology of malignant melanoma
9. The potential of intratumoral unsealed radioactive source therapy
10. An early phase II study of intratumoral P-32 chromic phosphate injection therapy for patients with refractory solid tumors and solitary metastases
11. Radionuclide therapy of skin cancers and Bowen's disease using a specially designed skin patch
12. An abnormality in the p53 pathway following irradiation in many wild-type p53 human melanoma lines
13. Induction of p53 and melanoma cell death is reciprocal with down-regulation of E2F, cyclin D1 and pRB
14. Beta dose kernels for radionuclides of potential use in radioimmunotherapy
15. Radiation therapy of malignant melanoma
16. The relationship between total dose, number of fractions and fraction size in the response of malignant melanoma in patients
17. Locally advanced melanoma. Results of postoperative hypofractionated radiation therapy
18. The evolution of the role of radiation therapy in the management of mucocutaneous malignant melanoma
19. Stereotactic radiosurgery for cerebral metastatic melanoma
20. Optimization of radioimmunotherapy using human malignant melano-ma multicell spheroids as a model
21. Improved tumor targeting of rhenium-186-labeled anti-human high MW melanoma-associated antigen monoclonal antibody 763.74 following purification with anti-idiotype monoclonal antibody MK2-23
22. Bi-specific antibody and bivalent hapten radioimmunotherapy in CEA-producing medullary thyroid cancer xenograft
23. Boron neutron capture therapy of intracerebral melanoma using borophenylalanine as a capture agent
24. Radioisotope concentrator gene therapy using sodium/iodide symporter gene
25. Transfer of the human NaI symporter gene enhances iodide uptake in hepatoma cells
26. waf1/cip1 expression in stage I cutaneous malignant melanoma: Its relationship with p53, cell proliferation and survival
27. waf1/cip1 carboxy-terminal peptide exhibited cyclin-dependent kinase-inhibitory activity and cytotoxicity when introduced into human cells
28. Growth inhibition by CDK-cyclin and PCNA binding domain of p21 occurs by distinct mechanisms and is regulated by ubiquitin-proteasome pathway
29. Cyclin D1 overexpression in rat two-stage bladder carcinogenesis and its relationship with oncogenes, tumor suppressor genes, and cell proliferation
30. waf1/cip1 converts cancer cells from growth arrest to undergoing apoptosis
31. Internucleosomal DNA fragmentation in cultured cells under conditions reported to induce apoptosis may be caused by Mycoplasma endonucleases
32. Change in the frequency of apoptosis after low-and high-dose X-irradiation of human lymphocytes
33. Morphologic and biochemical hallmarks of apoptosis
34. Biodistribution and kinetics of holmium-166-chitosan complex (DW-166HC) in rats and mice